MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Value Type	Rank	Gene	description	Network Comparison Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 2101 to 2150 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	green	red	network_comparison
1051	homeobox protein dlx-2. [swissprot;acc:q07687]	Divided	5198.91	4757.46	1.09279
	signal recognition particle receptor alpha subunit (sr-alpha) (docking protein alpha) (dp-alpha). [swissprot;acc:p08240]	Subtracted	5737.17	5208.27	528.9
1052	homeobox protein dlx-5. [swissprot;acc:p56178]	Divided	5198.91	4757.46	1.09279
	protein-tyrosine phosphatase, non-receptor type 1 (ec 3.1.3.48) (protein-tyrosine phosphatase 1b) (ptp-1b). [swissprot;acc:p18031]	Subtracted	6807.51	6278.76	528.75
1053	fetal brain protein 239 (239fb). [swissprot;acc:q15777]	Divided	5198.91	4757.46	1.09279
	peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570]	Subtracted	5694.55	5166.04	528.51
1054	heat shock factor binding protein 1. [swissprot;acc:o75506]		6443.77	5915.42	528.35
	homeobox protein dlx-3. [swissprot;acc:o60479]	Divided	5198.91	4757.46	1.09279
1055	activated p21cdc42hs kinase. [refseq;acc:nm_005781]
	mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352]	Subtracted	5695.44	5167.15	528.29
1056	mitogen-activated protein kinase kinase kinase 7 interacting protein 2 isoform 1; tak1-binding protein 2. [refseq;acc:nm_015093]	Divided	5198.91	4757.46	1.09279
	xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736]	Subtracted	6941.48	6413.32	528.16
1057	mitochondrial translational release factor 1-like. [refseq;acc:nm_019041]		5696.12	5168.01	528.11
	tata element modulatory factor (tmf). [swissprot;acc:p82094]	Divided	5913.4	5412.23	1.0926
1058	protein-tyrosine phosphatase, non-receptor type 2 (ec 3.1.3.48) (t- cell protein-tyrosine phosphatase) (tcptp). [swissprot;acc:p17706]	Subtracted	6803.95	6275.86	528.09
	scy1-like 1; telomerase regulation-associated protein; ht019 protein; telomerase regulation-associated protein; n-terminal kinase-like protein; teratoma-associated tyrosine kinase; n-terminal kinase-like. [refseq;acc:nm_020680]	Divided	5913.4	5412.23	1.0926
1059	tgf beta-inducible nuclear protein 1; hairy cell leukemia protein 1. [refseq;acc:nm_014886]	Subtracted	4379.71	3853.64	526.07
	tubulin-specific chaperone c (tubulin-folding cofactor c) (cfc). [swissprot;acc:q15814]	Divided	6248.6	5719.01	1.0926
1060	polyadenylate-binding protein 3 (poly(a)-binding protein 3) (pabp 3) (testis-specific poly(a)-binding protein). [swissprot;acc:q9h361]	Subtracted	6316.61	5791.05	525.56
	putative acyl-coa thioester hydrolase cgi-16 (ec 3.1.2.-). [swissprot;acc:q9y305]	Divided	6248.6	5719.01	1.0926
1061	hskin17 protein. [refseq;acc:nm_012311]	Subtracted	6316.61	5791.05	525.56
	nuclear pore complex protein nup98 (nucleoporin nup98) (98 kda nucleoporin). [swissprot;acc:p52948]	Divided	5913.4	5412.23	1.0926
1062	ammecr1 protein. [refseq;acc:nm_015365]
	carnitine o-acetyltransferase (ec 2.3.1.7) (carnitine acetylase) (cat). [swissprot;acc:p43155]	Subtracted	6316.61	5791.05	525.56
1063	mrna-associated protein mrnp 41 (rae1 protein homolog). [swissprot;acc:p78406]	Divided	5913.4	5412.23	1.0926
	polyadenylate-binding protein 4 (poly(a)-binding protein 4) (pabp 4) (inducible poly(a)-binding protein) (ipabp) (activated-platelet protein-1) (app-1). [swissprot;acc:q13310]	Subtracted	6316.61	5791.05	525.56
1064	dead-box protein. [refseq;acc:nm_018665]	Divided	6248.6	5719.01	1.0926
	polyadenylate-binding protein 1 (poly(a)-binding protein 1) (pabp 1). [swissprot;acc:p11940]	Subtracted	6316.61	5791.05	525.56
1065	dehydrodolichyl diphosphate synthase. [refseq;acc:nm_024887]		6874.88	6350.81	524.07
	dna-(apurinic or apyrimidinic site) lyase (ec 4.2.99.18) (ap endonuclease 1) (apex nuclease) (apen) (ref-1 protein). [swissprot;acc:p27695]	Divided	6984.94	6393.81	1.09245
1066	junction plakoglobin (desmoplakin iii). [swissprot;acc:p14923]	Subtracted	6256.63	5732.73	523.9
	leucyl-trna synthetase. [refseq;acc:nm_020117]	Divided	5917.79	5417.06	1.09244
1067	probable leucyl-trna synthetase, mitochondrial precursor (ec 6.1.1.4) (leucine--trna ligase) (leurs). [swissprot;acc:q15031]			5417.07	1.09243
	tax interaction protein 1. [refseq;acc:nm_014604]	Subtracted	6256.63	5732.73	523.9
1068	argininosuccinate lyase (ec 4.3.2.1) (arginosuccinase) (asal). [swissprot;acc:p04424]		6380.4	5857.48	522.92
	exocyst complex component sec15a. [swissprot;acc:q8tag9]	Divided	6774.35	6201.54	1.09237
1069	elongation factor 2 (ef-2). [swissprot;acc:p13639]		6001.08	5494.73	1.09215
	glutamate carboxypeptidase-like protein 2 precursor. [swissprot;acc:q96kn2]	Subtracted	6774.12	6251.32	522.8
1070	metabotropic glutamate receptor 2 precursor (mglur2). [swissprot;acc:q14416]	Divided	6001.08	5494.73	1.09215
	thymidylate kinase (ec 2.7.4.9) (dtmp kinase). [swissprot;acc:p23919]	Subtracted	6565.03	6042.31	522.72
1071	40s ribosomal protein s30. [swissprot;acc:q05472]		6416.07	5893.97	522.1
	metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832]	Divided	6001.08	5494.73	1.09215
1072	electron transfer flavoprotein beta-subunit (beta-etf). [swissprot;acc:p38117]	Subtracted	8316.04	7794.41	521.63
	prefoldin subunit 3 (von hippel-lindau binding protein 1) (vhl binding protein-1) (vbp-1) (hibbj46). [swissprot;acc:q15765]	Divided	5687.2	5207.39	1.09214
1073	dimethylaniline monooxygenase [n-oxide forming] 5 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 5) (fmo 5) (dimethylaniline oxidase 5). [swissprot;acc:p49326]	Subtracted	5885.48	5364.3	521.18
	prefoldin subunit 2 (hspc231). [swissprot;acc:q9uhv9]	Divided	5687.2	5207.39	1.09214
1074	putative dimethylaniline monooxygenase [n-oxide forming] 6 (ec 1.14.13.8) (flavin-containing monooxygenase 6) (fmo 6) (dimethylaniline oxidase 6). [swissprot;acc:o60774]	Subtracted	5885.48	5364.3	521.18
	uxt protein (ubiquitously expressed transcript protein) (hspc024). [swissprot;acc:q9ubk9]	Divided	5687.2	5207.39	1.09214
1075	eukaryotic translation initiation factor 3 subunit 9 (eif-3 eta) (eif3 p116) (eif3 p110) (eif3b). [swissprot;acc:p55884]	Subtracted	4880.99	4359.82	521.17
	phosphatidate cytidylyltransferase 1 (ec 2.7.7.41) (cdp-diglyceride synthetase 1) (cdp-diglyceride pyrophosphorylase 1) (cdp- diacylglycerol synthase 1) (cds 1) (ctp:phosphatidate cytidylyltransferase 1) (cdp-dag synthase 1) (cdp-dg synthetase 1). [swissprot;acc:q92903]	Divided	7034.86	6441.56	1.09211

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.