MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	Interaction Map	red	green	network_comparison
1	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	CPD	Divided	Low confidence	16	32	2
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	HLX	Subtracted	High confidence	215	322	107
	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	LAMP1		Low confidence	223	330
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	UBAC1	Divided	High confidence	10	24	2.4
2	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	CDK4	Subtracted	Low confidence	223	330	107
	hbs1-like. [refseq;acc:nm_006620]	HBS1L		High confidence	215	322
	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	LAMP1	Divided	Low confidence	223	330	1.47982
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	no value		High confidence	15	28	1.86667
3	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	CDK4		Low confidence	223	330	1.47982
	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	CDK6	Subtracted				107
	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	PSCD1	Divided	High confidence	15	28	1.86667
	rad50-interacting protein 1. [refseq;acc:nm_021930]	RINT1	Subtracted		337	232	105
4	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	CDK6	Divided	Low confidence	223	330	1.47982
	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	PSCD2		High confidence	15	28	1.86667
	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	LAMP2	Subtracted	Low confidence	223	330	107
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	RHOBTB2		High confidence	337	232	105
5	cytohesin 4. [swissprot;acc:q9uia0]	PSCD4	Divided		15	28	1.86667
	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	LAMP2		Low confidence	223	330	1.47982
	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	OSBPL6	Subtracted		318	240	78
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	XAB1		High confidence	212	309	97
6	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	PSCD3	Divided		15	28	1.86667
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	OSBPL3	Subtracted	Low confidence	318	240	78
	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	OSBPL6	Divided				1.325
	protein x 0004. [refseq;acc:nm_016301]	ATPBD1C	Subtracted	High confidence	212	309	97
7	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	HLX	Divided		215	322	1.49767
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	OSBPL3		Low confidence	318	240	1.325
	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	OSBPL7	Subtracted				78
	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	UFC1		High confidence	288.754	212.554	76.2
8	hbs1-like. [refseq;acc:nm_006620]	HBS1L	Divided		215	322	1.49767
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	JPH3	Subtracted		288	362	74
	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	OSBPL7	Divided	Low confidence	318	240	1.325
	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	JMJD1C	Subtracted		305.472	247.246	58.226
9	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	MRPS17	Divided		58	44	1.31818
	gbp protein isoform a. [refseq;acc:nm_017870]	TMEM132A	Subtracted		305.399	247.213	58.186
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	JPH2		High confidence	288	362	74
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	XAB1	Divided		212	309	1.45755
10	jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]	JMJD1A	Subtracted	Low confidence	305.303	247.169	58.134
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	SLC25A43	Divided		58	44	1.31818
	protein x 0004. [refseq;acc:nm_016301]	ATPBD1C		High confidence	212	309	1.45755
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	SMPD2	Subtracted		288	362	74
11	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]	BEST1	Divided	Low confidence	37.318	28.4944	1.30966
	db83 protein. [swissprot;acc:p57088]	TMEM33	Subtracted	High confidence	288	362	74
	rad50-interacting protein 1. [refseq;acc:nm_021930]	RINT1	Divided		337	232	1.45259
	trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]	PRSS3	Subtracted	Low confidence	304.548	246.824	57.724
12	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	no value		High confidence	266.856	336.233	69.377
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	RHOBTB2	Divided		337	232	1.45259
	trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]	PRSS1	Subtracted	Low confidence	304.359	246.737	57.622
	vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]	BEST4	Divided		37.3475	28.5242	1.30933
13	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	GNG12	Subtracted	High confidence	266.856	336.233	69.377
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	no value	Divided	Low confidence	37.9984	29.1831	1.30207

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.