MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Value Type	Gene	description	Network Comparison Type	Filtered	Interaction Map	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 232 to 281 of 25824 in total

Filtered  : 1
Interaction Map  : High confidence

Rank	Value Type	description	Network Comparison Type	red	green	network_comparison
29	Rooted	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Subtracted	210.928	192.165	18.763
30	Measured	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	Divided	1834.59	895.633	2.04837
		melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Subtracted	23693.7	18263	5430.7
	Ranked	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]		267.14	336.075	68.935
		serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	Divided	187.457	243.678	1.29991
	Squared	cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]		143.692	457.521	3.18404
		trophinin. [swissprot;acc:q12816]	Subtracted	219048	129762	89286
	Rooted	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]		60.8022	79.5099	18.7077
		microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	Divided	26.0288	43.1914	1.65937
31	Measured	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]		1834.63	895.697	2.04827
		melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Subtracted	23693.7	18263	5430.7
	Ranked	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]		267.14	336.075	68.935
		serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005]	Divided	187.458	243.677	1.2999
	Squared	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Subtracted	106226	192141	85915
		beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	Divided	9924.76	25146.6	2.53372
	Rooted	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	Subtracted	40.0958	58.7986	18.7028
		protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	Divided	26.0288	43.1914	1.65937
32	Measured	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		1834.73	895.893	2.04793
		melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Subtracted	23693.7	18263	5430.7
	Ranked	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]		267.142	336.074	68.932
		serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4]	Divided	187.462	243.673	1.29985
	Squared	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]		9924.76	25146.6	2.53372
		pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	Subtracted	106226	192141	85915
	Rooted	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	Divided	26.0288	43.1914	1.65937
		gbp protein isoform a. [refseq;acc:nm_017870]	Subtracted	23.9771	42.4773	18.5002
33	Measured	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	Divided	1835.3	896.972	2.04611
		melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Subtracted	23693.7	18263	5430.7
	Ranked	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]		267.144	336.073	68.929
		serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154]	Divided	188.688	242.742	1.28647
	Squared	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	Subtracted	106226	192141	85915
		spermatogenesis associated 6. [refseq;acc:nm_019073]	Divided	9924.76	25146.6	2.53372
	Rooted	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Subtracted	25.6987	43.561	17.8623
		protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	Divided	26.0288	43.1914	1.65937
34	Measured	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]		1836.71	907.546	2.02382
		melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Subtracted	23693.7	18263	5430.7
	Ranked	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]		267.144	336.073	68.929
		serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153]	Divided	189.07	242.453	1.28235
	Squared	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]		9924.76	25146.6	2.53372
		pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	Subtracted	106226	192141	85915
	Rooted	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]		140.508	122.878	17.63
		guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	Divided	40.2812	24.3678	1.65305
35	Measured	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]		1836.71	907.564	2.02378
		melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Subtracted	23693.7	18263	5430.7
	Ranked	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]		267.636	335.359	67.723
		nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	Divided	260.532	204.309	1.27519
	Squared	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]		106226	192141	1.80879
		mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Subtracted			85915
	Rooted	apg3p; pc3-96 protein. [refseq;acc:nm_022488]		140.508	122.878	17.63
		guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	Divided	40.2812	24.3679	1.65304
36	Measured	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]		1836.76	907.741	2.02344

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.