MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Value Type	Hugo	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

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Showing element 380 to 429 of 16578 in total

Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	Interaction Map	red	network_comparison	green
40s ribosomal protein s8. [swissprot;acc:p09058]	1397	RPS8	Divided	High confidence	218.64	1.02145	214.049
	2249		Subtracted	Low confidence	200.909	3.706	197.203
	2283		Divided			1.01879
40s ribosomal protein s9. [swissprot;acc:p46781]	386	RPS9	Subtracted	High confidence	238.986	18.798	257.784
	439		Divided			1.07866
	4666		Subtracted	Low confidence	204.824	1.203	203.621
	4679		Divided			1.00591
40s ribosomal protein sa (p40) (34/67 kda laminin receptor) (colon carcinoma laminin-binding protein) (nem/1chd4) (multidrug resistance- associated protein mgr1-ag). [swissprot;acc:p08865]	755	no value	Subtracted	High confidence	224.244	10.267	234.511
	789		Divided			1.04578
	4099			Low confidence	202.893	1.01079	200.728
	4100		Subtracted			2.165
43 kda receptor-associated protein of the synapse (rapsyn) (acetylcholine receptor-associated 43 kda protein) (43 kda postsynaptic protein). [swissprot;acc:q13702]	2215	RAPSN		High confidence	215.547	1.353	214.194
	2232		Divided			1.00632
	2866		Subtracted	Low confidence	202.663	3.395	199.268
	2906		Divided			1.01704
44050 protein. [refseq;acc:nm_178832]	2506	C10orf83		High confidence	151.386	1.0025	151.009
	2553		Subtracted			0.377
	3824		Divided	Low confidence	199.574	1.01318	196.978
	3840		Subtracted			2.596
45 kda calcium-binding protein precursor (cab45) (stromal cell-derived factor 4) (sdf-4). [swissprot;acc:q9brk5]	2147	SDF4	Divided	High confidence	206.442	1.00688	207.862
	2167		Subtracted			1.42
	2500		Divided	Low confidence	198.748	1.01819	195.198
	2581		Subtracted			3.55
5'-amp-activated protein kinase, beta-1 subunit (ampk beta-1 chain) (ampkb). [swissprot;acc:q9y478]	879	PRKAB1	Divided	High confidence	212.002	1.03946	203.954
	892		Subtracted			8.048
	2349			Low confidence	201.395	3.665	197.73
	2381		Divided			1.01854
5'-amp-activated protein kinase, beta-2 subunit (ampk beta-2 chain). [swissprot;acc:o43741]	877	PRKAB2		High confidence	212.002	1.03946	203.954
	890		Subtracted			8.048
	2318			Low confidence	201.408	3.677	197.731
	2351		Divided			1.0186
5'-amp-activated protein kinase, catalytic alpha-1 chain (ec 2.7.1.-) (ampk alpha-1 chain). [swissprot;acc:q13131]	876	PRKAA1		High confidence	212.002	1.03946	203.954
	889		Subtracted			8.048
	1674			Low confidence	200.836	4.056	196.78
	1683		Divided			1.02061
5'-amp-activated protein kinase, catalytic alpha-2 chain (ec 2.7.1.-) (ampk alpha-2 chain). [swissprot;acc:p54646]	875	PRKAA2		High confidence	212.002	1.03946	203.954
	888		Subtracted			8.048
	1676			Low confidence	200.826	4.055	196.771
	1681		Divided			1.02061
5'-amp-activated protein kinase, gamma-1 subunit (ampk gamma-1 chain) (ampkg). [swissprot;acc:p54619]	874	PRKAG1		High confidence	212.002	1.03946	203.954
	887		Subtracted			8.048
	2295		Divided	Low confidence	196.86	1.01875	193.236
	2416		Subtracted			3.624
5'-amp-activated protein kinase, gamma-2 subunit (ampk gamma-2 chain) (ampk gamma2) (h91620p). [swissprot;acc:q9ugj0]	880	PRKAG2	Divided	High confidence	212.002	1.03946	203.954
	893		Subtracted			8.048
	2304		Divided	Low confidence	196.768	1.01871	193.154
	2437		Subtracted			3.614
5'-amp-activated protein kinase, gamma-3 subunit (ampk gamma-3 chain) (ampk gamma3). [swissprot;acc:q9ugi9]	878	PRKAG3	Divided	High confidence	212.002	1.03946	203.954
	891		Subtracted			8.048
	2294		Divided	Low confidence	196.869	1.01876	193.244

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.