MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	Value Type	description	green	red	Network Comparison Type	Interaction Map	Filtered	network_comparison

Results: HTML CSV LaTeX

Showing element 501 to 550 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	green	red	Network Comparison Type	network_comparison
63	Squared	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	129762	219048	Divided	1.68808
		serine/threonine protein phosphatase pp1-alpha 1 catalytic subunit (ec 3.1.3.16) (pp-1a). [swissprot;acc:p08129]	124480	189976	Subtracted	65496
	Rooted	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	31.7576	43.4554	Divided	1.36835
		melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	120.823	137.446	Subtracted	16.623
64	Measured	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	10307.5	6475.5		3832
		glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]	2765.82	4489.19	Divided	1.6231
	Ranked	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	204.309	260.532	Subtracted	56.223
		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	336.159	266.868	Divided	1.25965
	Squared	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	81169.7	144940	Subtracted	63770.3
		melanoma antigen, family b, 6. [refseq;acc:nm_173523]	129762	219048	Divided	1.68808
	Rooted	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	47.2654	63.8686		1.35128
		melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	120.823	137.446	Subtracted	16.623
65	Measured	cleavage stimulation factor subunit 3; cleavage stimulation factor, 3' pre-rna, subunit 3, 77kd. [refseq;acc:nm_001326]	18702.6	22515.5		3812.9
		neuralized-like. [refseq;acc:nm_004210]	2690.25	1657.68	Divided	1.6229
	Ranked	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	336.077	267.136		1.25807
		serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	243.678	187.457	Subtracted	56.221
	Squared	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	129762	219048	Divided	1.68808
		microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	81155	144912	Subtracted	63757
	Rooted	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	47.2654	63.8686	Divided	1.35128
		melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	120.823	137.446	Subtracted	16.623
66	Measured	a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]	14008	17757.5		3749.5
		nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	3221.38	1991.03	Divided	1.61795
	Ranked	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	336.077	267.136		1.25807
		uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48]	243.678	187.458	Subtracted	56.22
	Squared	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	129762	219048	Divided	1.68808
		microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	81154.7	144911	Subtracted	63756.3
	Rooted	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	47.2654	63.8686	Divided	1.35128
		trophinin. [swissprot;acc:q12816]	120.823	137.446	Subtracted	16.623
67	Measured	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	10307.5	6475.5	Divided	1.59177
		raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (raf-1) (c-raf). [swissprot;acc:p04049]	14007.3	17756.5	Subtracted	3749.2
	Ranked	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	336.075	267.14	Divided	1.25805
		serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, beta isoform (pp2a, subunit b, b-beta isoform) (pp2a, subunit b, b55- beta isoform) (pp2a, subunit b, pr55-beta isoform) (pp2a, subunit b, r2-beta isoform). [swissprot;acc:q00005]	243.677	187.458	Subtracted	56.219
	Squared	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	81136.5	144876		63739.5
		melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	129762	219048	Divided	1.68808
	Rooted	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	47.2654	63.8686	Subtracted	16.6032
		myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]			Divided	1.35128
68	Measured	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	10307.5	6475.5		1.59177
		cyclin g2. [swissprot;acc:q16589]	13995.7	17738.6	Subtracted	3742.9
	Ranked	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	336.075	267.139	Divided	1.25805
		serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, gamma isoform (pp2a, subunit b, b-gamma isoform) (pp2a, subunit b, b55-gamma isoform) (pp2a, subunit b, pr55-gamma isoform) (pp2a, subunit b, r2-gamma isoform) (imypno1). [swissprot;acc:q9y2t4]	243.673	187.462	Subtracted	56.211
	Squared	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	78454.6	139741		61286.4
		melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	129762	219048	Divided	1.68808
	Rooted	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	47.2654	63.8686	Subtracted	16.6032
		glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]			Divided	1.35128
69	Measured	cyclin g1 (cyclin g). [swissprot;acc:p51959]	13995.6	17738.5	Subtracted	3742.9
		spermatogenesis associated 6. [refseq;acc:nm_019073]	10307.5	6475.5	Divided	1.59177
	Ranked	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	336.075	267.14		1.25805
		nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	228.934	284.753	Subtracted	55.819
	Squared	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	129762	219048	Divided	1.68808
		pre-mrna cleavage complex ii protein pcf11 (fragment). [swissprot;acc:o94913]	118639	178263	Subtracted	59624

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.