MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1312 to 1361 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	network_comparison	green
656	GABRA2	gamma-aminobutyric-acid receptor alpha-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p47869]	Subtracted	214.256	12.116	202.14
657	GABRA6	gamma-aminobutyric-acid receptor alpha-6 subunit precursor (gaba(a) receptor). [swissprot;acc:q16445]
	SYN3	synapsin iii. [swissprot;acc:o14994]	Divided	229.072	1.0577	216.576
658	no value	aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]
	GABRG2	gamma-aminobutyric-acid receptor gamma-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p18507]	Subtracted	214.256	12.116	202.14
659	GABRA4	gamma-aminobutyric-acid receptor alpha-4 subunit precursor (gaba(a) receptor). [swissprot;acc:p48169]
	HEY1	hairy/enhancer-of-split related with yrpw motif 1 (hairy and enhancer of split related-1) (hesr-1) (cardiovascular helix-loop-helix factor 2) (hes-related repressor protein 2 herp2). [swissprot;acc:q9y5j3]	Divided	229.072	1.0577	216.576
660	ABLIM2	actin binding lim protein 2. [refseq;acc:nm_032432]
	GABRE	gamma-aminobutyric-acid receptor epsilon subunit precursor (gaba(a) receptor). [swissprot;acc:p78334]	Subtracted	214.256	12.116	202.14
661	GABRA1	gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867]
	HEYL	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]	Divided	229.072	1.0577	216.576
662	GABRA3	gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]	Subtracted	214.256	12.116	202.14
	SYN2	synapsin ii. [swissprot;acc:q92777]	Divided	229.072	1.0577	216.576
663	MRRF	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]
	NDUFA6	nadh-ubiquinone oxidoreductase b14 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b14) (ci-b14). [swissprot;acc:p56556]	Subtracted	214.256	12.115	202.141
664	PDXDC1	similar to expressed sequence aa415817. [sptrembl;acc:q8n4q9]
	PEX5	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]	Divided	229.072	1.0577	216.576
665	HEY2	hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]
	HOXD9	homeobox protein hox-d9 (hox-4c) (hox-5.2). [swissprot;acc:p28356]	Subtracted	214.254	12.088	202.166
666	EIF3I	eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [swissprot;acc:q13347]		250.465	12.085	238.38
	HES1	transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [swissprot;acc:q14469]	Divided	229.072	1.0577	216.576
667	no value	trinucleotide repeat containing 15. [refseq;acc:nm_015575]	Subtracted	250.465	12.085	238.38
	ECH1	delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011]	Divided	229.072	1.0577	216.576
668	ABLIM1	actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313]
	FTSJ3	ftsj homolog 3; likely ortholog of mouse ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 3. [refseq;acc:nm_017647]	Subtracted	244.495	12.076	232.419
669	no value	presenilin-like protein 2 (ec 3.4.99.-) (sppl2a protein). [swissprot;acc:q8tct8]		232.601	11.933	244.534
	SYN1	synapsin i (brain protein 4.1). [swissprot;acc:p17600]	Divided	229.072	1.0577	216.576
670	GNL2	autoantigen ngp-1. [swissprot;acc:q13823]		250.302	1.05694	236.817
	RANP1	gtp-binding nuclear protein ran (tc4) (ran gtpase) (androgen receptor- associated protein 24). [swissprot;acc:p17080]	Subtracted	232.601	11.933	244.534
671	no value	presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]
	NUBP1	nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384]	Divided	210.739	1.05688	199.398
672	no value	dok-like protein. [refseq;acc:nm_024872]	Subtracted	216.504	11.882	204.622
	NUBP2	nucleotide binding protein 2 (nbp 2). [swissprot;acc:q9y5y2]	Divided	210.739	1.05688	199.398
673	CASK	peripheral plasma membrane protein cask (ec 2.7.1.-) (hcask) (calcium/calmodulin-dependent serine protein kinase) (lin-2 homolog). [swissprot;acc:o14936]		226.497	1.05664	214.355
	DOK2	docking protein 2 (p56(dok-2)) (downstream of tyrosine kinase 2). [swissprot;acc:o60496]	Subtracted	216.504	11.882	204.622
674	DOK1	docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704]
	HIF3A	hypoxia-inducible factor-3 alpha isoform a; inhibitory pas domain protein. [refseq;acc:nm_152794]	Divided	226.497	1.05664	214.355
675	FRK	tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [swissprot;acc:p42685]	Subtracted	216.504	11.882	204.622
	SIM1	single-minded homolog 1. [swissprot;acc:p81133]	Divided	226.497	1.05664	214.355
676	MRTO4	ribosomal protein p0-like protein; 60s acidic ribosomal protein po; ribosomal protein, large, p0-like. [refseq;acc:nm_016183]	Subtracted	245.84	11.796	257.636
	POLR2G	dna-directed rna polymerase ii 19 kda polypeptide (ec 2.7.7.6) (rpb7). [swissprot;acc:p52433]	Divided	232.469	1.05654	245.613
677	FBL	fibrillarin (34 kda nucleolar scleroderma antigen). [swissprot;acc:p22087]	Subtracted	245.246	11.763	233.483
	LSM4	u6 snrna-associated sm-like protein lsm4 (glycine-rich protein) (grp). [swissprot;acc:q9y4z0]	Divided	228.944	1.05628	216.745
678	PPIL4	peptidylprolyl isomerase-like 4; cyclophilin-type peptidyl-prolyl cis-trans isomerase; ppiase; serologically defined breast cancer antigen ny-br-18. [refseq;acc:nm_139126]	Subtracted	226.135	11.73	214.405
	SNX5	sorting nexin 5. [swissprot;acc:q9y5x3]	Divided	208.482	1.05609	220.175
679	no value	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]		132.413	1.05602	125.389
	SNX5	sorting nexin 5. [swissprot;acc:q9y5x3]	Subtracted	208.482	11.693	220.175
680	HOXB4	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	Divided	132.413	1.05602	125.389
	SFRS18	sr rich protein. [refseq;acc:nm_032870]	Subtracted	225.293	11.653	213.64
681	HOXC5	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	Divided	132.413	1.05602	125.389

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.