MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2051 to 2100 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	red	green	network_comparison
513	Squared	transforming protein rhoc (h9). [swissprot;acc:p08134]	19987.6	23960.7	1.19878
	Rooted	60s ribosomal protein l4 (l1). [swissprot;acc:p36578]	51.5881	47.3127	1.09036
514	Measured	1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	7477	8532.02	1.1411
	Ranked	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	218.613	204.382	1.06963
	Squared	thiosulfate sulfurtransferase (ec 2.8.1.1) (rhodanese). [swissprot;acc:q16762]	19987.6	23960.7	1.19878
	Rooted	xpa-binding protein 2 (hcnp protein) (pp3898). [swissprot;acc:q9hcs7]	58.7805	64.0772	1.09011
515	Measured	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]	3890.53	4439.07	1.14099
	Ranked	pescadillo homolog 1. [swissprot;acc:o00541]	251.297	234.941	1.06962
	Squared	3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]	19987.6	23960.7	1.19878
	Rooted	u6 snrna-associated sm-like protein lsm1 (small nuclear ribonuclear casm) (cancer-associated sm-like). [swissprot;acc:o15116]	56.3551	61.4322	1.09009
516	Measured	n-acetylgalactosamine kinase (ec 2.7.1.-) (galnac kinase) (galactokinase 2). [swissprot;acc:q01415]	4910.6	5600.61	1.14051
	Ranked	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	228.255	213.422	1.0695
	Squared	transforming protein rhoa (h12). [swissprot;acc:p06749]	19987.6	23960.7	1.19878
	Rooted	adenylate kinase isoenzyme 2, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p54819]	50.7935	46.6042	1.08989
517	Measured	galactose-1-phosphate uridylyltransferase (ec 2.7.7.12) (gal-1-p uridylyltransferase) (udp-glucose--hexose-1-phosphate uridylyltransferase). [swissprot;acc:p07902]	4910.6	5600.61	1.14051
	Ranked	metaxin 2. [swissprot;acc:o75431]	219.537	234.793	1.06949
	Squared	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	19263.3	23092.3	1.19877
	Rooted	eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [swissprot;acc:q13347]	50.0578	54.5502	1.08974
518	Measured	udp-glucose 4-epimerase (ec 5.1.3.2) (galactowaldenase) (udp- galactose 4-epimerase). [swissprot;acc:q14376]	4910.6	5600.61	1.14051
	Ranked	nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	250.858	234.563	1.06947
	Squared	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]	11447.3	13719.2	1.19847
	Rooted	trinucleotide repeat containing 15. [refseq;acc:nm_015575]	50.0578	54.5502	1.08974
519	Measured	glycogen [starch] synthase, muscle (ec 2.4.1.11). [swissprot;acc:p13807]	9648.27	10994.9	1.13957
	Ranked	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	218.702	204.582	1.06902
	Squared	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	22387.1	26827.3	1.19834
	Rooted	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	114.309	124.527	1.08939
520	Measured	endo-beta-n-acetylglucosaminidase. [refseq;acc:nm_022759]	9642.22	10986.4	1.13941
	Ranked	sqv-7-like protein (fragment). [sptrembl;acc:o95454]	214.754	229.565	1.06897
	Squared	paxillin. [swissprot;acc:p49023]	22387.1	26827.3	1.19834
	Rooted	breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [refseq;acc:nm_005872]	61.1902	66.6503	1.08923
521	Measured	u4/u6-associated rna splicing factor. [refseq;acc:nm_004698]	5390.78	6142.07	1.13937
	Ranked	exosome complex exonuclease rrp41 (ec 3.1.13.-) (ribosomal rna processing protein 41) (p12a). [swissprot;acc:q9npd3]	215.237	230.07	1.06891
	Squared	carboxypeptidase a5. [refseq;acc:nm_080385]	53174	44377.4	1.19822
	Rooted	cdc5-like; cdc5 (cell division cycle 5, s. pombe, homolog)-like; cell division cycle 5, s. pombe, homolog-like; cdc5-related protein. [refseq;acc:nm_001253]	61.1902	66.6503	1.08923
522	Measured	glycogen [starch] synthase, liver (ec 2.4.1.11). [swissprot;acc:p54840]	9634.98	10976.2	1.1392
	Ranked	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	222.893	208.523	1.06891
	Squared	carboxypeptidase b precursor (ec 3.4.17.2) (pancreas-specific protein) (pasp). [swissprot;acc:p15086]	53174	44377.4	1.19822
	Rooted	septin 10 isoform 1. [refseq;acc:nm_144710]	113.733	123.871	1.08914
523	Measured	aquaporin 4 (wch4) (mercurial-insensitive water channel) (miwc). [swissprot;acc:p55087]	10640.2	12117.8	1.13887
	Ranked	exosome complex exonuclease rrp4 (ec 3.1.13.-) (ribosomal rna processing protein 4). [swissprot;acc:q13868]	215.237	230.07	1.06891
	Squared	neutral and basic amino acid transport protein rbat (b(0,+)-type amino acid transport protein) (nbat) (d2h). [swissprot;acc:q07837]	53174	44377.4	1.19822
	Rooted	ribonucleoside-diphosphate reductase m1 chain (ec 1.17.4.1) (ribonucleotide reductase large chain). [swissprot;acc:p23921]	66.377	72.2842	1.08899
524	Measured	aquaporin 5. [swissprot;acc:p55064]	10640	12117.6	1.13887
	Ranked	exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [swissprot;acc:q9nqt5]	215.237	230.07	1.06891
	Squared	aminoacylase-1 (ec 3.5.1.14) (n-acyl-l-amino-acid amidohydrolase) (acy-1). [swissprot;acc:q03154]	53174	44377.4	1.19822
	Rooted	brain protein 44. [swissprot;acc:o95563]	113.374	123.463	1.08899
525	Measured	lens fiber major intrinsic protein (mip26) (mp26) (aquaporin 0). [swissprot;acc:p30301]	10639.8	12117.3	1.13887
	Ranked	exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [swissprot;acc:q9nqt4]	215.237	230.07	1.06891
	Squared	carboxypeptidase a1 precursor (ec 3.4.17.1). [swissprot;acc:p15085]	53174	44377.4	1.19822
	Rooted	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	113.374	123.463	1.08899

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.