MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	description	Network Comparison Type	Rank	Value Type	Hugo	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 801 to 850 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Value Type	Hugo	red	network_comparison	green
5-aminolevulinic acid synthase, erythroid-specific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-e). [swissprot;acc:p22557]	Divided	786	Squared	ALAS2	27407.7	1.16492	31927.7
		1910	Measured		6858.84	1.06246	7287.27
		2312	Rooted		70.5239	1.0191	71.8706
		2491	Ranked		194.527	1.00284	195.08
	Subtracted	618	Squared		27407.7	4520	31927.7
		1577	Measured		6858.84	428.43	7287.27
		2253	Rooted		70.5239	1.3467	71.8706
		2502	Ranked		194.527	0.553	195.08
5-aminolevulinic acid synthase, nonspecific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-h). [swissprot;acc:p13196]	Divided	791	Squared	ALAS1	27407.7	1.16492	31927.7
		1915	Measured		6858.84	1.06246	7287.27
		2317	Rooted		70.5239	1.0191	71.8706
		2496	Ranked		194.527	1.00284	195.08
	Subtracted	623	Squared		27407.7	4520	31927.7
		1583	Measured		6858.84	428.43	7287.27
		2258	Rooted		70.5239	1.3467	71.8706
		2507	Ranked		194.527	0.553	195.08
5-formyltetrahydrofolate cyclo-ligase (ec 6.3.3.2) (5,10-methenyl- tetrahydrofolate synthetase) (methenyl-thf synthetase) (mthfs). [swissprot;acc:p49914]	Divided	1635	Squared	MTHFS	27290.4	1.10739	30221.1
		1833	Measured		6175.23	1.06439	6572.85
		2095	Rooted		64.8399	1.0253	66.4806
		2754	Ranked		210.638	1.00002	210.642
	Subtracted	1284	Squared		27290.4	2930.7	30221.1
		1726	Measured		6175.23	397.62	6572.85
		2057	Rooted		64.8399	1.6407	66.4806
		2754	Ranked		210.638	0.004	210.642
5-methyltetrahydrofolate--homocysteine methyltransferase (ec 2.1.1.13) (methionine synthase, vitamin-b12 dependent) (ms). [swissprot;acc:q99707]	Divided	941	Squared	MTR	26005.2	1.1544	30020.3
		1115	Measured		5795.13	1.08957	6314.19
		1362	Rooted		61.5231	1.04084	64.0358
		1921	Ranked		221.607	1.01012	219.386
	Subtracted	791	Squared		26005.2	4015.1	30020.3
		1094	Measured		5795.13	519.06	6314.19
		1395	Rooted		61.5231	2.5127	64.0358
		1884	Ranked		221.607	2.221	219.386
54 kda nuclear rna- and dna-binding protein (p54(nrb)) (p54nrb) (55 kda nuclear protein) (nmt55) (non-pou domain-containing octamer- binding protein) (dna-binding p52/p100 complex, 52 kda subunit). [swissprot;acc:q15233]	Divided	353	Squared	NONO	71383	1.24362	57399.3
		2028	Measured		10243.4	1.05746	9686.82
		2532	Ranked		190.405	1.00214	190.812
		2636	Rooted		80.3593	1.00647	79.843
	Subtracted	187	Squared		71383	13983.7	57399.3
		924	Measured		10243.4	556.58	9686.82
		2538	Ranked		190.405	0.407	190.812
		2579	Rooted		80.3593	0.5163	79.843
6-phosphofructokinase, liver type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme b) (pfk-b). [swissprot;acc:p17858]	Divided	642	Squared	PFKL	16123.9	1.17898	19009.7
		764	Measured		4250.18	1.11269	4729.12
		1822	Ranked		240.32	1.01151	243.085
		1905	Rooted		52.8713	1.02906	54.4076
	Subtracted	1268	Measured		4250.18	478.94	4729.12
		1325	Squared		16123.9	2885.8	19009.7
		1733	Ranked		240.32	2.765	243.085
		2124	Rooted		52.8713	1.5363	54.4076
6-phosphofructokinase, muscle type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme a) (pfk-a) (phosphofructokinase-m). [swissprot;acc:p08237]	Divided	643	Squared	PFKM	16126.5	1.17897	19012.6
		763	Measured		4250.54	1.11272	4729.67

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.