MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Value Type	Network Comparison Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 451 to 500 of 3730 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence

Rank	description	Filtered	green	red	network_comparison
226	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	0	758.411	658.544	1.15165
	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	1	7279.6	9035	1.24114
227	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]
	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]	0	369.011	424.258	1.14972
228	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	1	7279.6	9035	1.24114
	sh3-containing grb2-like protein 1 (sh3 domain protein 2b) (extra eleven-nineteen leukemia fusion gene) (een) (een fusion partner of mll). [swissprot;acc:q99961]	0	4696.36	4089.65	1.14835
229	dj718p11.1.2 (novel class ii aminotransferase similar to serine palmotyltransferase (isoform 2)) (fragment). [sptrembl;acc:q9ugb5]		368.317	320.752	1.14829
	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	1	7279.6	9035	1.24114
230	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]
	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]	0	1718.6	1498.17	1.14713
231	alcohol dehydrogenase class iii chi chain (ec 1.1.1.1) (glutathione- dependent formaldehyde dehydrogenase) (ec 1.2.1.1) (fdh). [swissprot;acc:p11766]		1759.22	2017.91	1.14705
	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	1	7279.6	9035	1.24114
232	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	0	1906.28	1663.73	1.14579
	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	1	7279.6	9035	1.24114
233	maguk p55 subfamily member 2 (mpp2 protein) (discs, large homolog 2). [swissprot;acc:q14168]	0	399.534	348.823	1.14538
	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	1	7279.6	9035	1.24114
234	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]		6410.58	5181.2	1.23728
	wiskott-aldrich syndrome protein family member 3 (wasp-family protein member 3) (verprolin homology domain-containing protein 3). [swissprot;acc:q9upy6]	0	4550.64	5202.89	1.14333
235	integrin beta-3 precursor (platelet membrane glycoprotein iiia) (gpiiia) (cd61 antigen). [swissprot;acc:p05106]		1843.92	1612.86	1.14326
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	1	6410.58	5181.2	1.23728
236	peroxisomal acyl-coenzyme a thioester hydrolase 2a (ec 3.1.2.2) (peroxisomal long-chain acyl-coa thioesterase 2) (zap128). [swissprot;acc:p49753]	0	3103.01	2715.75	1.1426
	spliceosomal u5 snrnp-specific 15 kda protein (dim1 protein homolog) (thioredoxin-like u5 snrnp protein u5-15kd). [swissprot;acc:o14834]	1	5828.46	4723.53	1.23392
237	p28 ing5. [refseq;acc:nm_032329]	0	2243.69	2551.23	1.13707
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	1	5631.2	4567.04	1.23301
238	casein kinase i alpha s-like. [refseq;acc:nm_145203]	0	1933.94	2198.47	1.13678
	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	1	22440.4	27642.5	1.23182
239	carboxypeptidase b precursor. [refseq;acc:nm_020361]		6265.8	7711.38	1.23071
	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	0	434.366	382.142	1.13666
240	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	1	6265.79	7711.36	1.23071
	putative eukaryotic translation initiation factor 1a (eif-1a) (eif- 4c). [swissprot;acc:o75642]	0	1676.18	1475.83	1.13575
241	keratin associated protein 9.2. [refseq;acc:nm_031961]		1079.01	1225.47	1.13574
	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	1	6265.76	7711.31	1.23071
242	max protein. [swissprot;acc:p25912]		5704.87	4640.26	1.22943
	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	0	642.343	729.216	1.13524
243	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	1	5208.98	4246.95	1.22652
	keratin associated protein 4.3 (fragment). [sptrembl;acc:q9byr4]	0	1079.36	1225.09	1.13502
244	keratin associated protein 2-4; keratin associated protein 2.4. [refseq;acc:nm_033184]
	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]	1	5211.25	4250.14	1.22614
245	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]		5212.33	4251.65	1.22595
	keratin associated protein 1.5. [refseq;acc:nm_031957]	0	1079.36	1225.09	1.13502
246	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	1	5213.05	4252.66	1.22583
	keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371]	0	1079.36	1225.09	1.13502
247	keratin associated protein 1-3; keratin associated protein 1.3. [refseq;acc:nm_030966]
	wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]	1	7865.15	6416.68	1.22574
248	keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060]	0	1079.37	1225.09	1.135
	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]	1	7859.6	6417.18	1.22477
249	keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]	0	1079.37	1225.08	1.135
	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]	1	7859.59	6417.18	1.22477
250	keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]	0	1079.37	1225.08	1.135
	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]	1	7859.6	6417.18	1.22477

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.