MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2630 to 2679 of 9634 in total

Value Type  : Measured
Network Comparison Type  : Divided

Rank	description	Interaction Map	Filtered	red	green	network_comparison
710	lifeguard; kiaa0950 protein. [refseq;acc:nm_012306]	High confidence	1	5317.78	5944.25	1.11781
	mitochondrial ribosomal protein l23; l23 mitochondrial-related protein; ribosomal protein related to l23 (mitochondrial); ribosomal protein l23-like. [refseq;acc:nm_021134]	Low confidence	0	1425.14	1448.79	1.01659
	rna 3'-terminal phosphate cyclase-like protein (hspc338). [swissprot;acc:q9y2p8]		1	7822.22	8158.36	1.04297
711	sam-domain protein samsn-1 (sam domain, sh3 domain and nuclear localisation signals protein 1). [swissprot;acc:q9nsi8]			8534.3	8182.77	1.04296
	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]		0	5699.32	5607.7	1.01634
	sterol regulatory element binding protein-2 (srebp-2) (sterol regulatory element-binding transcription factor 2). [swissprot;acc:q12772]	High confidence	1	5317.78	5944.25	1.11781
712	double c2-like domains, beta. [refseq;acc:nm_003585]	Low confidence	0	2049.53	2017.07	1.01609
	mitogen-activated protein kinase kinase kinase 3 (ec 2.7.1.-) (mapk/erk kinase kinase 3) (mek kinase 3) (mekk 3). [swissprot;acc:q99759]		1	8281.14	8636.93	1.04296
	sterol regulatory element binding protein-1 (srebp-1) (sterol regulatory element-binding transcription factor 1). [swissprot;acc:p36956]	High confidence		5317.78	5944.25	1.11781
713	c1 domain-containing phosphatase and tensin-like protein isoform 2; putative protein tyrosine phosphatase; c1 domain-containing phosphatase and tensin-like protein; tensin 2. [refseq;acc:nm_015319]	Low confidence		7273.8	7586.18	1.04295
	synaptotagmin iii (sytiii). [swissprot;acc:q9bqg1]		0	2053.54	2021.15	1.01603
	upf0202 protein kiaa1709. [swissprot;acc:q9h0a0]	High confidence	1	3996.81	4465.61	1.11729
714	actin, cytoplasmic 2 (gamma-actin). [swissprot;acc:p02571]	Low confidence	0	2090.86	2058.14	1.0159
	dihydropyrimidine dehydrogenase [nadp+] precursor (ec 1.3.1.2) (dpd) (dhpdhase) (dihydrouracil dehydrogenase) (dihydrothymine dehydrogenase). [swissprot;acc:q12882]	High confidence	1	5222.71	5834.57	1.11715
	sam and sh3 domain containing 1. [refseq;acc:nm_015278]	Low confidence		8534.42	8183.02	1.04294
715	dendritic cell protein. [refseq;acc:nm_006360]	High confidence		6593.17	7364.55	1.117
	mitogen-activated protein kinase kinase kinase 2 (ec 2.7.1.-) (mapk/erk kinase kinase 2) (mek kinase 2) (mekk 2). [swissprot;acc:q9y2u5]	Low confidence		8280.29	8635.76	1.04293
	th1-like; th1 drosophila homolog; th1-like (drosophila homolog); negative elongation factor proteins c and d. [refseq;acc:nm_016397]		0	9654.03	9504.83	1.0157
716	diaphanous protein homolog 1 (diaphanous-related formin 1) (drf1). [swissprot;acc:o60610]		1	8084.21	8431.08	1.04291
	guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388]		0	3108.28	3156.83	1.01562
	potential carboxypeptidase-like protein x2 precursor. [swissprot;acc:q8n436]	High confidence	1	6593.17	7364.55	1.117
717	carboxypeptidase n catalytic chain precursor (ec 3.4.17.3) (arginine carboxypeptidase) (kininase 1) (serum carboxypeptidase n) (scpn) (anaphylatoxin inactivator) (plasma carboxypeptidase b). [swissprot;acc:p15169]
	forkhead box protein c2 (forkhead-related protein fkhl14) (mesenchyme fork head protein 1) (mfh-1 protein) (transcription factor fkh-14). [swissprot;acc:q99958]	Low confidence	0	2107.1	2074.73	1.0156
	sestrin 3. [swissprot;acc:p58005]		1	8106.21	8453.94	1.0429
718	cpz gene product. [refseq;acc:nm_003652]	High confidence		6593.17	7364.55	1.117
	ran-binding protein 2-like 1 isoform 2; sperm membrane protein bs-63; ran-binding protein 2-like 1. [refseq;acc:nm_032260]	Low confidence	0	1877.89	1906.74	1.01536
	sestrin 2 (hi95). [swissprot;acc:p58004]		1	8106.17	8453.96	1.0429
719	carboxypeptidase h precursor (ec 3.4.17.10) (cph) (carboxypeptidase e) (cpe) (enkephalin convertase) (prohormone processing carboxypeptidase). [swissprot;acc:p16870]	High confidence		6593.17	7364.55	1.117
	flotillin-1. [swissprot;acc:o75955]	Low confidence		8106.26	8453.92	1.04289
	importin alpha-2 subunit (karyopherin alpha-2 subunit) (srp1-alpha) (rag cohort protein 1). [swissprot;acc:p52292]		0	2784.62	2827.2	1.01529
720	atp-dependent helicase ddx8 (rna helicase hrh1) (deah-box protein 8). [swissprot;acc:q14562]		1	7946.35	8286.99	1.04287
	forkhead box protein l1 (forkhead-related protein fkhl11) (forkhead- related transcription factor 7) (freac-7). [swissprot;acc:q12952]		0	2107.93	2076.43	1.01517
	potential carboxypeptidase x precursor (ec 3.4.17.-) (metallocarboxypeptidase cpx-1). [swissprot;acc:q96sm3]	High confidence	1	6593.17	7364.55	1.117
721	forkhead box protein d4-like 1. [swissprot;acc:q9nu39]	Low confidence	0	2108.44	2077.47	1.01491
	oxysterol-binding protein 1. [swissprot;acc:p22059]		1	8594.6	8962.95	1.04286
	syntaxin 7. [swissprot;acc:o15400]	High confidence		5580.97	6233.52	1.11692
722	histidyl-trna synthetase homolog (ec 6.1.1.21) (histidine--trna ligase homolog) (hisrs). [swissprot;acc:p49590]			8061.05	9002.33	1.11677
	isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252]	Low confidence	0	2040.98	2071.38	1.01489
	sestrin 1 (p53-regulated protein pa26). [swissprot;acc:q9y6p5]		1	8106.39	8453.87	1.04286
723	forkhead box protein d4b (myeloid factor-gamma). [swissprot;acc:q8wxt5]		0	2108.51	2077.61	1.01487
	histidyl-trna synthetase (ec 6.1.1.21) (histidine--trna ligase) (hisrs). [swissprot;acc:p12081]	High confidence	1	8056.09	8996.46	1.11673
	oxysterol-binding protein 2 (oxysterol binding protein-related protein 4) (osbp-related protein 4) (orp-4). [swissprot;acc:q969r2]	Low confidence		8591.36	8958.94	1.04278
724	forkhead box protein d4 (forkhead-related protein fkhl9) (forkhead- related transcription factor 5) (freac-5) (myeloid factor-alpha). [swissprot;acc:q12950]		0	2108.64	2077.88	1.0148
	phenylalanyl-trna synthetase alpha chain (ec 6.1.1.20) (phenylalanine- -trna ligase alpha chain) (phers) (cml33). [swissprot;acc:q9y285]	High confidence	1	5384.41	6012.82	1.11671
	rest corepressor. [refseq;acc:nm_015156]	Low confidence		8774.84	9149.63	1.04271
725	iron-responsive element binding protein 1 (ire-bp 1) (iron regulatory protein 1) (irp1) (ferritin repressor protein) (aconitate hydratase) (ec 4.2.1.3) (citrate hydro-lyase) (aconitase). [swissprot;acc:p21399]			7892.07	8228.85	1.04267
	microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268]		0	2140.04	2171.71	1.0148
	phenylalanine-trna synthetase. [refseq;acc:nm_006567]	High confidence	1	5384.41	6012.82	1.11671
726	dna mismatch repair protein mlh3 (mutl protein homolog 3). [swissprot;acc:q9uhc1]			6327.86	7064.13	1.11635
	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]	Low confidence		8130.72	8477.45	1.04264

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.