MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Network Comparison Type	Rank	Gene	Value Type	description	Interaction Map	Hugo	network_comparison	Filtered	red	green

Results: HTML CSV LaTeX

Showing element 273 to 322 of 66312 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Value Type	description	Interaction Map	Hugo	network_comparison	red	green
35	Measured	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	Low confidence	DNASE2B	1.18866	33111.4	39358.1
		guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	High confidence	GNAQ	2.02378	1836.71	907.564
	Ranked	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]		NFYC	1.27519	260.532	204.309
		tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Low confidence	TOB2	1.14959	297.273	258.59
	Squared	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	High confidence	MRPS17	1.80879	106226	192141
		necdin. [swissprot;acc:q99608]	Low confidence	NDN	1.33073	82347.8	61881.5
	Rooted	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	High confidence	GNAQ	1.65304	40.2812	24.3679
		regulator of g-protein signaling 12 (rgs12). [swissprot;acc:o14924]	Low confidence	RGS12	1.15329	54.8296	63.2347
36	Measured	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	High confidence	GNAZ	2.02344	1836.76	907.741
		proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Low confidence	FOS	1.17513	6462.09	7593.77
	Ranked	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	High confidence	NFYA	1.27519	260.532	204.309
		tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	Low confidence	TOB1	1.14906	296.837	258.33
	Squared	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]		MAGED1	1.33073	82347.8	61881.5
		pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	High confidence	PANK1	1.80879	106226	192141
	Rooted	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	Low confidence	CHRAC1	1.15273	55.7086	64.217
		guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	High confidence	GNAZ	1.65294	40.2805	24.369
37	Measured	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]		GNAT1	2.02339	1836.76	907.763
		jun dimerization protein. [refseq;acc:nm_130469]	Low confidence	no value	1.17513	6462.09	7593.77
	Ranked	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]		CHRAC1	1.14874	250.244	217.843
		protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	High confidence	PPP1R14A	1.27273	322	253
	Squared	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Low confidence	MAGEF1	1.33073	82347.8	61881.5
		pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	High confidence	PANK2	1.80879	106226	192141
	Rooted	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]		GNAT1	1.65293	40.2805	24.3691
		testis-specific protein tex28. [swissprot;acc:o15482]	Low confidence	TEX28P2	1.14428	51.7058	59.166
38	Measured	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	High confidence	GNAT2	2.02337	1836.76	907.774
		rab11-family interacting protein 4. [refseq;acc:nm_032932]	Low confidence	RAB11FIP4	1.17403	7407.56	8696.7
	Ranked	glucosamine-6-phosphate isomerase. [refseq;acc:nm_138335]		GNPDA2	1.14456	247.202	282.937
		microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	High confidence	MFAP4	1.27273	322	253
	Squared	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Low confidence	MAGEB6B	1.33073	82347.8	61881.5
		pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	High confidence	PANK3	1.80879	106226	192141
	Rooted	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]	Low confidence	GOSR2	1.14428	51.7058	59.166
		guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	High confidence	GNAT2	1.65292	40.2804	24.3692
39	Measured	eferin. [swissprot;acc:o75154]	Low confidence	RAB11FIP3	1.17403	7407.56	8696.7
		guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	High confidence	GNAI2	2.02312	1836.8	907.903
	Ranked	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	Low confidence	GNPDA1	1.14456	247.202	282.937
		protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	High confidence	PPP1R14D	1.27273	322	253
	Squared	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Low confidence	no value	1.33073	82347.8	61881.5
		mitochondrial solute carrier protein. [refseq;acc:nm_145305]	High confidence	SLC25A43	1.80879	106226	192141
	Rooted	dual specificity mitogen-activated protein kinase kinase 4 (ec 2.7.1.-) (map kinase kinase 4) (jnk activating kinase 1) (c-jun n- terminal kinase kinase 1) (jnkk) (sapk/erk kinase 1) (sek1). [swissprot;acc:p45985]	Low confidence	MAP2K4	1.13614	63.4164	55.8176
		guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	High confidence	GNAI2	1.65285	40.28	24.37
40	Measured	fos-related antigen 2. [swissprot;acc:p15408]	Low confidence	FOSL2	1.17277	6480.59	7600.25
		guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	High confidence	GNAI1	2.02297	1836.81	907.978
	Ranked	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]		FCN2	1.27273	322	253
		son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	Low confidence	SON	1.14245	255.382	223.538
	Squared	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	High confidence	ATG4A	1.78564	144940	81169.7
		melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Low confidence	MAGEA9	1.33073	82347.8	61881.5
	Rooted	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	High confidence	GNAI1	1.65281	40.2797	24.3705
		protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	Low confidence	PPP1R14A	1.13601	55.7075	63.2842
41	Measured	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	High confidence	GNAI3	2.02297	1836.81	907.978
		protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Low confidence	FOSB	1.17264	6481.62	7600.61

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.