MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Hugo	Value Type	description	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 844 to 893 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Network Comparison Type	Hugo	description	Interaction Map	red	network_comparison	green
211	Subtracted	FMO4	dimethylaniline monooxygenase [n-oxide forming] 4 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 4) (fmo 4) (dimethylaniline oxidase 4). [swissprot;acc:p31512]	Low confidence	209.765	10.01	199.755
212	Divided	CUL1	cullin homolog 1 (cul-1). [swissprot;acc:q13616]	High confidence	285.684	1.13261	252.234
		GNG11	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	Low confidence	211.383	1.05011	221.976
	Subtracted	SLC15A2	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]		201.43	10	191.43
		SYNCRIP	ns1-associated protein 1. [refseq;acc:nm_006372]	High confidence	237.302	24.892	212.41
213	Divided	FMO4	dimethylaniline monooxygenase [n-oxide forming] 4 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 4) (fmo 4) (dimethylaniline oxidase 4). [swissprot;acc:p31512]	Low confidence	209.765	1.05011	199.755
		PLDN	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]	High confidence	210.693	1.127	186.95
	Subtracted	HNRNPR	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]		237.302	24.892	212.41
		NEGR1	a kindred of iglon. [refseq;acc:nm_173808]	Low confidence	199.671	9.983	209.654
214	Divided	LASS2	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	High confidence	191.644	1.12605	170.192
		OGT	udp-n-acetylglucosamine--peptide n-acetylglucosaminyltransferase 110 kda subunit (ec 2.4.1.-) (o-glcnac transferase p110 subunit). [swissprot;acc:o15294]	Low confidence	206.583	1.05001	196.743
	Subtracted	MRPL4	mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956]	High confidence	241.282	24.838	266.12
		NMBR	neuromedin-b receptor (nmb-r) (neuromedin-b-preferring bombesin receptor). [swissprot;acc:p28336]	Low confidence	199.671	9.983	209.654
215	Divided	no value	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	High confidence	112	1.125	126
		NEGR1	a kindred of iglon. [refseq;acc:nm_173808]	Low confidence	199.671	1.05	209.654
	Subtracted	EIF4G1	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	High confidence	237.292	24.835	212.457
		GRPR	gastrin-releasing peptide receptor (grp-r) (grp-preferring bombesin receptor). [swissprot;acc:p30550]	Low confidence	199.671	9.983	209.654
216	Divided	MYH4	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	High confidence	112	1.125	126
		NMBR	neuromedin-b receptor (nmb-r) (neuromedin-b-preferring bombesin receptor). [swissprot;acc:p28336]	Low confidence	199.671	1.05	209.654
	Subtracted	BRS3	bombesin receptor subtype-3 (brs-3). [swissprot;acc:p32247]			9.983
		SNRPD2	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	High confidence	226.471	24.702	201.769
217	Divided	GRPR	gastrin-releasing peptide receptor (grp-r) (grp-preferring bombesin receptor). [swissprot;acc:p30550]	Low confidence	199.671	1.05	209.654
		MYH8	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	High confidence	112	1.125	126
	Subtracted	OGT	udp-n-acetylglucosamine--peptide n-acetylglucosaminyltransferase 110 kda subunit (ec 2.4.1.-) (o-glcnac transferase p110 subunit). [swissprot;acc:o15294]	Low confidence	206.583	9.84	196.743
		RPL26	60s ribosomal protein l26. [swissprot;acc:q02877]	High confidence	242.326	24.682	267.008
218	Divided	BRS3	bombesin receptor subtype-3 (brs-3). [swissprot;acc:p32247]	Low confidence	199.671	1.05	209.654
		MYH2	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	High confidence	112	1.125	126
	Subtracted	LEF1	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	Low confidence	208.289	9.751	198.538
		RPL35	60s ribosomal protein l35. [swissprot;acc:p42766]	High confidence	242.333	24.666	266.999
219	Divided	BACH1	transcription regulator protein bach1 (btb and cnc homolog 1) (ha2303). [swissprot;acc:o14867]	Low confidence	172.647	1.04991	164.44
		MYH3	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	High confidence	112	1.125	126
	Subtracted	no value	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]		242.339	24.647	266.986
		NFYA	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	Low confidence	214.032	9.748	204.284
220	Divided	MYH1	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	High confidence	112	1.125	126
		NFE2L2	nuclear factor erythroid 2 related factor 2 (nf-e2 related factor 2) (nfe2-related factor 2) (nuclear factor, erythroid derived 2, like 2) (hebp1). [swissprot;acc:q16236]	Low confidence	172.647	1.04991	164.44
	Subtracted	MRPL2	mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	High confidence	242.339	24.647	266.986
		TLR2	toll-like receptor 2 precursor (toll/interleukin 1 receptor-like protein 4). [swissprot;acc:o60603]	Low confidence	207.926	9.65	198.276
221	Divided	no value	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	High confidence	112	1.125	126
		BACH2	transcription regulator protein bach2 (btb and cnc homolog 2). [swissprot;acc:q9byv9]	Low confidence	172.647	1.04991	164.44
	Subtracted	no value	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]		189.373	9.544	179.829
		EIF1B	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]	High confidence	242.627	24.524	267.151
222	Divided	MYH7B	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]		112	1.125	126
		UBE2E1	ubiquitin-conjugating enzyme e2 e1 (ec 6.3.2.19) (ubiquitin-protein ligase e1) (ubiquitin carrier protein e1) (ubch6). [swissprot;acc:p51965]	Low confidence	203.935	1.04979	214.089
	Subtracted	no value	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	High confidence	242.153	24.52	266.673
		CASK	peripheral plasma membrane protein cask (ec 2.7.1.-) (hcask) (calcium/calmodulin-dependent serine protein kinase) (lin-2 homolog). [swissprot;acc:o14936]	Low confidence	212.056	9.532	202.524
223	Divided	GTF3C3	general transcription factor iiic, polypeptide 3, 102kda; general transcription factor iiic, polypeptide 3 (102kd); transcription factor iiic, 102 kd. [refseq;acc:nm_012086]		217.228	1.04979	206.926
		MYH13	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	High confidence	112	1.125	126
	Subtracted	SIM1	single-minded homolog 1. [swissprot;acc:p81133]	Low confidence	212.056	9.532	202.524
		SRR	serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]	High confidence	242.153	24.52	266.673
224	Divided	SLC15A2	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]		185.969	1.12285	165.623

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.