MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2501 to 2550 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Value Type	Network Comparison Type	red	green	network_comparison
313	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	MYH2	Rooted	Divided	95.0526	85.3206	1.11406
	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]	PPP1R2	Measured		21644.2	18098.7	1.1959
	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	RRM2B	Ranked		232.473	211.207	1.10069
	u6 snrna-associated sm-like protein lsm5. [swissprot;acc:q9y4y9]	LSM5	Measured	Subtracted	4567.04	5631.2	1064.16
314	fzr1 protein; fizzy-related protein; cdc20-like 1b. [refseq;acc:nm_016263]	FZR1	Squared	Divided	71576.8	56326.7	1.27074
	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	SLC39A6	Rooted	Subtracted	59.6399	51.9242	7.7157
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	MAGEA8	Ranked		88.2482	110.265	22.0168
	methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582]	METAP1		Divided	244.126	268.604	1.10027
	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	MYH3	Rooted		95.0526	85.3206	1.11406
	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	RRM2B	Measured	Subtracted	6563.65	7627.29	1063.64
	ring finger protein 25 (ec 6.3.2.-). [swissprot;acc:q96bh1]	RNF25	Squared		51519.3	44060.4	7458.9
	type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210]	PPP1R2P9	Measured	Divided	21632.5	18090	1.19583
315	arginyl-trna synthetase-like; arginine-trna ligase. [refseq;acc:nm_020320]	RARS2	Squared	Subtracted	31819.7	39222.2	7402.5
	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]	GAD2	Rooted		59.6399	51.9242	7.7157
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	MAGEC1	Ranked		88.2482	110.265	22.0168
	methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579]	METAP2		Divided	244.126	268.604	1.10027
	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	MYH1	Rooted		95.0526	85.3206	1.11406
	proprotein convertase subtilisin/kexin type 5 precursor (ec 3.4.21.-) (proprotein convertase pc5) (subtilisin/kexin-like protease pc5) (convertase pc5) (pc6) (hpc6). [swissprot;acc:q92824]	PCSK5	Squared		71576.8	56326.7	1.27074
	ribosome biogenesis regulatory protein homolog. [swissprot;acc:q15050]	RRS1	Measured		21370.8	17896.5	1.19413
	vav proto-oncogene. [swissprot;acc:p15498]	VAV1		Subtracted	6644.99	7707.8	1062.81
316	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	NAPG	Rooted		59.6399	51.9242	7.7157
	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	MAGEA4	Ranked		88.2482	110.265	22.0168
	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	no value	Rooted	Divided	95.0526	85.3206	1.11406
	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	WASL	Squared		28918.3	36746	1.27068
	protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567]	EIF1	Ranked		242.694	267.017	1.10022
	regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754]	RCC1	Squared	Subtracted	44848.2	52108.3	7260.1
	serine/threonine protein phosphatase pp1-alpha 1 catalytic subunit (ec 3.1.3.16) (pp-1a). [swissprot;acc:p08129]	PPP1CA	Measured	Divided	21370.8	17896.5	1.19413
	wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516]	WIPF1		Subtracted	6603.41	7664.65	1061.24
317	adiponectin receptor 2. [refseq;acc:nm_024551]	ADIPOR2		Divided	3153.1	3762.56	1.19329
	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	MYH7B	Rooted		95.0526	85.3206	1.11406
	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	GAD1		Subtracted	59.6399	51.9242	7.7157
	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	no value	Ranked		88.2482	110.265	22.0168
	nucleoside diphosphate kinase 3 (ec 2.7.4.6) (ndk 3) (ndp kinase 3) (nm23-h3) (dr-nm23). [swissprot;acc:q13232]	NME3	Squared	Divided	33982.3	43159.1	1.27005
	splicing factor 3b subunit 3 (spliceosome associated protein 130) (sap 130) (sf3b130) (pre-mrna splicing factor sf3b 130 kda subunit). [swissprot;acc:q15393]	no value	Ranked		224.445	204.044	1.09998
	vav-3 protein. [swissprot;acc:q9ukw4]	VAV3	Measured	Subtracted	6647.43	7706.18	1058.75
	zinc finger homeobox protein 1b (smad interacting protein 1) (smadip1) (hrihfb2411). [swissprot;acc:o60315]	ZEB2	Squared		44848.2	52108.3	7260.1
318	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	AGPAT3	Measured		7485.08	8543.66	1058.58
	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	CHRAC1	Rooted		38.8223	46.4975	7.6752
	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	MAGEA10	Ranked		88.2482	110.265	22.0168
	mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]	MRPL3		Divided	242.011	266.18	1.09987
	mitochondrial import receptor subunit tom20 homolog (mitochondrial 20 kda outer membrane protein) (outer mitochondrial membrane receptor tom20). [swissprot;acc:q15388]	TOMM20	Squared		46739.9	59134.5	1.26518
	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	MYH13	Rooted		95.0526	85.3206	1.11406
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	no value	Measured		34190.9	40795.8	1.19318
	transcription factor 8 (nil-2-a zinc finger protein) (negative regulator of il2). [swissprot;acc:p37275]	ZEB1	Squared	Subtracted	44848.2	52108.3	7260.1
319	1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	AGPAT4	Measured		7477	8532.02	1055.02
	60s ribosomal protein l19. [swissprot;acc:p14118]	RPL19	Ranked	Divided	240.73	264.729	1.09969
	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	B9D1	Rooted	Subtracted	53.4993	45.9227	7.5766
	maguk p55 subfamily member 3 (mpp3 protein) (discs, large homolog 3). [swissprot;acc:q13368]	MPP3	Squared		37147.5	44372.1	7224.6
	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	MAGEB4	Ranked		88.2482	110.265	22.0168
	peroxisomal farnesylated protein (33 kda housekeeping protein) (peroxin 19). [swissprot;acc:p40855]	PEX19	Squared	Divided	46739.9	59134.5	1.26518

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.