MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Hugo	Rank	Gene	Network Comparison Type	description	Value Type	network_comparison	Interaction Map	red	Filtered	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 7460 in total

Hugo  : no value
Value Type  : Ranked
Interaction Map  : High confidence

Rank	Network Comparison Type	description	network_comparison	red	Filtered	green
1	Subtracted	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	12977	8906	0	21883
2	Divided	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	1.86667	15	1	28
3		nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8]	2.47638	4475.84	0	11083.9
4		mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	2.45711	8906		21883
	Subtracted	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]	10363	11525		21888
5	Divided	ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]	2.17144	5510.5		11965.7
7	Subtracted	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	9070	22286		13216
8	Divided	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]	1.89918	11525		21888
	Subtracted	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	9070	22286		13216
9		homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]
12		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	69.377	266.856	1	336.233
		succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	8136	19403	0	11267
13	Divided	heat shock 70 kda protein 1 (hsp70.1) (hsp70-1/hsp70-2). [swissprot;acc:p08107]	1.77804	5210.5		9264.5
	Subtracted	dystrophin. [swissprot;acc:p11532]	7822.3	10232.5		18054.8
14	Divided		1.76446
15		succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	1.72211	19403		11267
16	Subtracted	ptd016 protein. [refseq;acc:nm_016125]	6816	18050		11234
17	Divided	fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	1.69451	11543		6812
	Subtracted	ero1-like. [refseq;acc:nm_014584]	6683	13853		20536
18	Divided	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	1.68629	22286		13216
19		homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]
	Subtracted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	69.313	266.865	1	336.178
		nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8]	6608.06	4475.84	0	11083.9
20	Divided	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	1.68629	22286		13216
21	Subtracted	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	6521.7	14592		21113.7
22		ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]	6455.2	5510.5		11965.7
24	Divided	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	1.66289	13730.5		8257
25		lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]
	Subtracted	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	6052	22440		16388
26		protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	69	322	1	253
27	Divided	ptd016 protein. [refseq;acc:nm_016125]	1.60673	18050	0	11234
	Subtracted	60s ribosomal protein l37a. [swissprot;acc:p12751]	5557.5	12941.7		18499.2
29		ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	5473.5	13730.5		8257
30	Divided	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	1.57201	7395		11625
		serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	1.29991	187.457	1	243.678
	Subtracted	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	5473.5	13730.5	0	8257
32	Divided	importin 9. [refseq;acc:nm_018085]	1.52929	13292.2		8691.76
33		nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733]
34	Subtracted	fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	4731	11543		6812
35	Divided	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	1.5182	3208.8		4871.6
	Subtracted	importin 9. [refseq;acc:nm_018085]	4600.44	13292.2		8691.76
36		nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733]
37	Divided	dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]	1.49458	3859		2582
39		ero1-like. [refseq;acc:nm_014584]	1.48242	13853		20536
40		filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	1.48218	3845		5699
41		60s ribosomal protein l21. [swissprot;acc:p46778]	1.47871	9994.33		6758.83
		protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	1.27273	322	1	253
	Subtracted	beta-carotene dioxygenase 2; putative b,b-carotene-9',10'-dioxygenase. [refseq;acc:nm_031938]	4230	7395	0	11625
43	Divided	jun dimerization protein. [refseq;acc:nm_130469]	1.2714	204.641	1	160.957
	Subtracted	dok-like protein. [refseq;acc:nm_024872]	4212	17571	0	21783

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.