MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Hugo	Rank	Gene	Network Comparison Type	description	Value Type	network_comparison	Interaction Map	red	Filtered	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 6456 in total

Hugo  : no value
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Network Comparison Type	description	network_comparison	red	green
2	Divided	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	1.86667	15	28
12	Subtracted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	69.377	266.856	336.233
19		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	69.313	266.865	336.178
26		protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	69	322	253
30	Divided	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	1.29991	187.457	243.678
41		protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	1.27273	322	253
43		jun dimerization protein. [refseq;acc:nm_130469]	1.2714	204.641	160.957
56		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	1.25998	266.856	336.233
63		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	1.25973	266.865	336.178
65	Subtracted	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	56.221	187.457	243.678
85	Divided	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	1.24949	88.2482	110.265
88		hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]
94		melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]
99		melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]
	Subtracted	jun dimerization protein. [refseq;acc:nm_130469]	43.684	204.641	160.957
133		formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	32.167	226.887	194.72
134		huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	32.094	226.884	194.79
147	Divided	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	1.2009	50.7983	42.3003
149		atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	1.19718	142	170
152		myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	1.19565	55	46
153	Subtracted	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	28.138	226.582	198.444
162		atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	28	142	170
168	Divided	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	1.18722	82.5916	98.0548
178		formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	1.1652	226.887	194.72
179		huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	1.16476	226.884	194.79
182	Subtracted	rd protein. [swissprot;acc:p18615]	26.793	227.357	254.15
191	Divided	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	1.14179	226.582	198.444
	Subtracted	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	25.979	241.373	267.352
196		hpaii tiny fragments locus 9c. [refseq;acc:nm_022727]	25.889	272.781	246.892
198		40s ribosomal protein s29. [swissprot;acc:p30054]	25.793	241.849	267.642
200		60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	25.527	241.808	267.335
203		40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750]	25.32	240.758	266.078
208		60s ribosomal protein l23 (l17). [swissprot;acc:p23131]	24.935	240.782	265.717
210		rna-binding protein. [refseq;acc:nm_019027]	24.892	237.302	212.41
211		apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]
215	Divided	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	1.125	112	126
219	Subtracted	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	24.647	242.339	266.986
221	Divided	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	1.125	112	126
222	Subtracted	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	24.52	242.153	266.673
233		60s ribosomal protein l7. [swissprot;acc:p18124]	24.257	235.727	259.984
238	Divided	rd protein. [swissprot;acc:p18615]	1.11785	227.357	254.15
242	Subtracted	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	24.067	241.892	265.959
243		60s ribosomal protein l23a. [swissprot;acc:p29316]	24.061	241.884	265.945
246		60s ribosomal protein l12 like protein. [sptrembl;acc:o60886]	23.945	243.583	267.528
247	Divided	rna-binding protein. [refseq;acc:nm_019027]	1.11719	237.302	212.41
	Subtracted	60s ribosomal protein l12. [swissprot;acc:p30050]	23.944	243.583	267.527
248	Divided	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	1.11719	237.302	212.41
	Subtracted	dj999l4.1 (novel protein similar to ribosomal protein l12 (rpl12)). [sptrembl;acc:q9nq02]	23.944	243.583	267.527
259		adenylate kinase isoenzyme 4, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p27144]	23.556	242.14	265.696
264		60s ribosomal protein l10a (csa-19). [swissprot;acc:p53025]		243.24	266.796

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.