MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3062 to 3111 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
red  : 0.00001
green  : 0.00001
network_comparison  : 1

Rank	description	Hugo
3062	sparc precursor (secreted protein acidic and rich in cysteine) (osteonectin) (on) (basement membrane protein bm-40). [swissprot;acc:p09486]	SPARC
3063	mitochondrial 28s ribosomal protein s30 (s30mt) (mrp-s30) (programmed cell death protein 9) (bm047). [swissprot;acc:q9np92]	MRPS30
3064	complement component c7 precursor. [swissprot;acc:p10643]	C7
3065	wnt1 inducible signaling pathway protein 3 isoform 1; wnt-1 signaling pathway protein 3; wnt1 signaling pathway protein 3; wnt-1 inducible signaling pathway protein 3. [refseq;acc:nm_003880]	WISP3
3066	vascular endothelial growth factor a precursor (vegf-a) (vascular permeability factor) (vpf). [swissprot;acc:p15692]	VEGFA
3067	retinoic acid receptor rxr-beta. [swissprot;acc:p28702]	no value
3068	headcase homolog; hhdc for homolog of drosophila headcase. [refseq;acc:nm_016217]	HECA
3069	bone morphogenetic protein 5 precursor (bmp-5). [swissprot;acc:p22003]	BMP5
3070	mam domain containing glycosylphosphatidylinositol anchor 1; glycosyl-phosphatidyl-inositol-mam. [refseq;acc:nm_153487]	MDGA1
3071	serine/threonine kinase 38; serine threonine protein kinase. [refseq;acc:nm_007271]	STK38
3072	pak1 interacting protein 1; pak1-interacting protein; pak/plc-interacting protein 1. [refseq;acc:nm_017906]	PAK1IP1
3073	rwd domain containing 1; ptd013 protein; cgi-24 protein. [refseq;acc:nm_015952]	RWDD1
3074	tu12b1-ty protein. [refseq;acc:nm_016575]	NT5DC3
3075	ubiquitin carboxyl-terminal hydrolase 5 (ec 3.1.2.15) (ubiquitin thiolesterase 5) (ubiquitin-specific processing protease 5) (deubiquitinating enzyme 5) (isopeptidase t). [swissprot;acc:p45974]	USP5
3076	placental protein 11 precursor (ec 3.4.21.-) (pp11). [swissprot;acc:p21128]	no value
3077	h2a histone family, member j isoform 1. [refseq;acc:nm_018267]	H2AFJ
3078	camp responsive element binding protein-like 2. [refseq;acc:nm_001310]	CREBL2
3079	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	CYP27B1
3080	nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733]	no value
3081	nadh-ubiquinone oxidoreductase 30 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-30kd) (ci-30kd). [swissprot;acc:o75489]	PTPMT1
3082	alpha crystallin b chain (alpha(b)-crystallin) (rosenthal fiber component). [swissprot;acc:p02511]	CRYAB
3083	glycine receptor beta chain precursor (glycine receptor 58 kda subunit). [swissprot;acc:p48167]	GLRB
3084	mitogen-activated protein kinase kinase 1 interacting protein 1 (mek binding partner 1) (mp1) (pro2783). [swissprot;acc:q9uha4]	MAP2K1IP1
3085	udp-glucuronosyltransferase 2b10 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:p36537]	UGT2B10
3086	udp-glucuronosyltransferase 2b15 precursor, microsomal (ec 2.4.1.17) (udpgt) (udpgth-3) (hlug4). [swissprot;acc:p54855]	no value
3087	fructose-bisphosphate aldolase c (ec 4.1.2.13) (brain-type aldolase). [swissprot;acc:p09972]	ALDOC
3088	14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655]	YWHAE
3089	camp-dependent protein kinase type i-alpha regulatory chain (tissue- specific extinguisher-1) (tse1). [swissprot;acc:p10644]	PRKAR1A
3090	enhancer of zeste homolog 1 (enx-2). [swissprot;acc:q92800]	EZH1
3091	transcription factor-like protein 4 (max-like bhlhzip protein) (bigmax protein) (mlx). [swissprot;acc:q9uh92]	MLX
3092	developmentally regulated gtp-binding protein 2 (drg 2). [swissprot;acc:p55039]	DRG2
3093	ptd016 protein. [refseq;acc:nm_016125]	no value
3094	ubiquitin-conjugating enzyme e2-24 kda (ec 6.3.2.19) (ubiquitin- protein ligase) (ubiquitin carrier protein) (e2-epf5). [swissprot;acc:q16763]	UBE2S
3095	erythroid differentiation-related factor 1. [refseq;acc:nm_015608]	C10orf137
3096	nucleoplasmin 3. [swissprot;acc:o75607]	NPM3
3097	sec23-interacting protein p125; phospholipase. [refseq;acc:nm_007190]	SEC23IP
3098	enhancer of zeste homolog 2 (enx-1). [swissprot;acc:q15910]	EZH2
3099	caveolin-1. [swissprot;acc:q03135]	CAV1
3100	presenilin enhancer 2; hematopoietic stem/progenitor cells protein mds033. [refseq;acc:nm_172341]	no value
3101	gamma-interferon inducible lysosomal thiol reductase precursor (gamma-interferon-inducible protein ip-30). [swissprot;acc:p13284]
3102	protein cgi-140 (protein ptd008) (my006 protein). [swissprot;acc:q9y284]	C19orf56
3103	dna ligase i (ec 6.5.1.1) (polydeoxyribonucleotide synthase [atp]). [swissprot;acc:p18858]	LIG1
3104	glioma tumor suppressor candidate region gene 2 protein (p60). [swissprot;acc:q9nzm5]	SNORD23
3105	transforming growth factor beta 1 precursor (tgf-beta 1). [swissprot;acc:p01137]	TGFB1
3106	prostate tumor overexpressed gene 1; prostate tumor over expressed gene 1. [refseq;acc:nm_017432]	PTOV1
3107	lyl-1 protein (lymphoblastic leukemia derived sequence 1). [swissprot;acc:p12980]	LYL1
3108	sorting nexin 16. [swissprot;acc:p57768]	SNX16
3109	wnt1 inducible signaling pathway protein 1 isoform 1 precursor; wnt-1 signaling pathway protein 1; wnt1 signaling pathway protein 1; wnt-1 inducible signaling pathway protein 1. [refseq;acc:nm_003882]	WISP1
3110	ras-related protein rab-2a. [swissprot;acc:p08886]	RAB2A
3111	serine/threonine protein kinase 3 (ec 2.7.1.37) (ste20-like kinase mst2) (mst-2) (mammalian ste20-like protein kinase 2) (serine/threonine protein kinase krs-1). [swissprot;acc:q13188]	STK3

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.