MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	description	Network Comparison Type	Rank	Value Type	Hugo	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Value Type	Hugo	red	network_comparison	green
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Divided	18	Ranked	GBE1	185.678	1.32082	245.247
		60	Measured		4489.19	1.6231	2765.82
		64	Rooted		63.8686	1.35128	47.2654
		245	Squared		8875.01	1.31131	6768.05
	Subtracted	54	Ranked		185.678	59.569	245.247
		67	Rooted		63.8686	16.6032	47.2654
		164	Measured		4489.19	1723.37	2765.82
		1962	Squared		8875.01	2106.96	6768.05
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	Divided	295		no value	30807.7	1.27733	39351.7
		509	Measured		7551.8	1.14278	8630.06
		805	Rooted		74.3557	1.0645	79.1513
		1038	Ranked		186.741	1.03148	181.041
	Subtracted	274	Squared		30807.7	8544	39351.7
		310	Measured		7551.8	1078.26	8630.06
		610	Rooted		74.3557	4.7956	79.1513
		1120	Ranked		186.741	5.7	181.041
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	Divided	294	Squared	AGPAT2	30826.5	1.2776	39383.9
		508	Measured		7556.75	1.14293	8636.87
		804	Rooted		74.3877	1.0646	79.1931
		1032	Ranked		186.664	1.03162	180.943
	Subtracted	273	Squared		30826.5	8557.4	39383.9
		307	Measured		7556.75	1080.12	8636.87
		609	Rooted		74.3877	4.8054	79.1931
		1115	Ranked		186.664	5.721	180.943
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	Divided	311	Squared	AGPAT4	30566.4	1.27154	38866.5
		514	Measured		7477	1.1411	8532.02
		822	Rooted		73.8577	1.06393	78.5795
		1048	Ranked		187.96	1.031	182.308
	Subtracted	280	Squared		30566.4	8300.1	38866.5
		319	Measured		7477	1055.02	8532.02
		631	Rooted		73.8577	4.7218	78.5795
		1128	Ranked		187.96	5.652	182.308
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	Divided	308	Squared	AGPAT3	30596.2	1.27205	38919.9
		513	Measured		7485.08	1.14143	8543.66
		811	Rooted		73.9102	1.06415	78.6514
		1043	Ranked		187.834	1.03128	182.137
	Subtracted	279	Squared		30596.2	8323.7	38919.9
		318	Measured		7485.08	1058.58	8543.66
		616	Rooted		73.9102	4.7412	78.6514
		1121	Ranked		187.834	5.697	182.137
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	Divided	3126	Measured	PLCB4	0.00001	1	0.00001
			Ranked
			Squared
			Rooted
	Subtracted		Measured		0	0	0
			Ranked
			Squared
			Rooted
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	Divided	588	Squared	HSPE1	23526.4	1.18502	27879.3
		1136	Measured		5790.65	1.08864	6303.92

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.