MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	Value Type	description	Network Comparison Type	red	green	network_comparison
1	no value	Measured	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Subtracted	41482.5	33356.5	8126
	HLX	Ranked	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]		215	322	107
	RINT1	Measured	rad50-interacting protein 1. [refseq;acc:nm_021930]	Divided	450.5	2394.5	5.31521
		Squared			48.0356	1357.07	28.2513
		Rooted			21.225	48.9336	2.30547
				Subtracted			27.7086
	UBAC1	Ranked	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Divided	10	24	2.4
		Squared		Subtracted	468498	322755	145743
2	no value	Ranked	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Divided	15	28	1.86667
		Squared		Subtracted	407289	263351	143938
	HBS1L	Ranked	hbs1-like. [refseq;acc:nm_006620]		215	322	107
	PSCD1	Measured	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]		41482.5	33356.5	8126
	RHOBTB2		rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Divided	450.5	2394.5	5.31521
		Squared			48.0356	1357.07	28.2513
		Rooted			21.225	48.9336	2.30547
				Subtracted			27.7086
3	HLX	Measured	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Divided	2597.5	698.5	3.71868
		Squared			1596.92	115.48	13.8285
		Rooted			50.9657	26.4292	1.92839
				Subtracted			24.5365
	PSCD1	Ranked	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Divided	15	28	1.86667
		Squared		Subtracted	407289	263351	143938
	PSCD2	Measured	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]		41482.5	33356.5	8126
	RINT1	Ranked	rad50-interacting protein 1. [refseq;acc:nm_021930]		337	232	105
4	HBS1L	Measured	hbs1-like. [refseq;acc:nm_006620]	Divided	2597.5	698.5	3.71868
		Squared			1596.92	115.48	13.8285
		Rooted			50.9657	26.4292	1.92839
				Subtracted			24.5365
	PSCD2	Ranked	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Divided	15	28	1.86667
		Squared		Subtracted	407289	263351	143938
	PSCD4	Measured	cytohesin 4. [swissprot;acc:q9uia0]		41482.5	33356.5	8126
	RHOBTB2	Ranked	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]		337	232	105
5	JPH3	Measured	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Divided	1153.5	339.5	3.39764
		Squared			314.926	27.2805	11.544
		Rooted			33.9632	18.4255	1.84327
	MRPS17		28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Subtracted	145.551	168.796	23.245
	PSCD3	Measured	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]		41482.5	33356.5	8126
	PSCD4	Ranked	cytohesin 4. [swissprot;acc:q9uia0]	Divided	15	28	1.86667
		Squared		Subtracted	407289	263351	143938
	XAB1	Ranked	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]		212	309	97
6	ATPBD1C		protein x 0004. [refseq;acc:nm_016301]
	JPH2	Measured	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Divided	1153.5	339.5	3.39764
		Squared			314.926	27.2805	11.544
		Rooted			33.9632	18.4255	1.84327
	PANK1		pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	Subtracted	145.551	168.796	23.245
	PSCD3	Ranked	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Divided	15	28	1.86667
		Squared		Subtracted	407289	263351	143938
	UBAC1	Measured	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]		44490.5	36927.5	7563
7	no value	Squared	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]		310840	442993	132153
	HLX	Ranked	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Divided	215	322	1.49767

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.