MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 1 to 50 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Value Type	red	green	network_comparison
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	18	GBE1	Ranked	185.678	245.247	1.32082
	60		Measured	4489.19	2765.82	1.6231
	64		Rooted	63.8686	47.2654	1.35128
	245		Squared	8875.01	6768.05	1.31131
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	295	no value		30807.7	39351.7	1.27733
	509		Measured	7551.8	8630.06	1.14278
	805		Rooted	74.3557	79.1513	1.0645
	1038		Ranked	186.741	181.041	1.03148
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	294	AGPAT2	Squared	30826.5	39383.9	1.2776
	508		Measured	7556.75	8636.87	1.14293
	804		Rooted	74.3877	79.1931	1.0646
	1032		Ranked	186.664	180.943	1.03162
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	311	AGPAT4	Squared	30566.4	38866.5	1.27154
	514		Measured	7477	8532.02	1.1411
	822		Rooted	73.8577	78.5795	1.06393
	1048		Ranked	187.96	182.308	1.031
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	308	AGPAT3	Squared	30596.2	38919.9	1.27205
	513		Measured	7485.08	8543.66	1.14143
	811		Rooted	73.9102	78.6514	1.06415
	1043		Ranked	187.834	182.137	1.03128
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	3126	PLCB4	Measured	0.00001	0.00001	1
			Ranked
			Squared
			Rooted
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	588	HSPE1	Squared	23526.4	27879.3	1.18502
	1136		Measured	5790.65	6303.92	1.08864
	1907		Rooted	63.4353	65.2789	1.02906
	1963		Ranked	211.633	213.703	1.00978
10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]	2922	ALDH1L1	Measured	0.00001	0.00001	1
			Ranked
			Squared
			Rooted
14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946]	1143	YWHAB	Squared	28551.5	32561.8	1.14046
	1411		Measured	5812.02	6262.07	1.07743
	1943		Rooted	61.3337	63.0838	1.02853
	2439		Ranked	220.681	221.425	1.00337
14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655]	3088	YWHAE	Measured	0.00001	0.00001	1
			Ranked
			Squared
			Rooted
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312]	1135	YWHAZ	Squared	28600.9	32641.7	1.14128
	1415		Measured	5815.33	6265.44	1.0774
	1961		Rooted	61.3419	63.0743	1.02824
	2396		Ranked	220.683	221.51	1.00375
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758]	921	HRSP12	Squared	25739.7	29768.2	1.15651
	1600		Measured	6336.22	6788.96	1.07145
	2036		Rooted	66.966	68.7832	1.02714
	2366		Ranked	203.353	202.529	1.00407
15 kda selenoprotein precursor. [swissprot;acc:o60613]	914	no value	Squared	29772.1	34456.5	1.15734
	1043		Measured	6344.41	6933.36	1.09283

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.