MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Value Type	Interaction Map	red	green	network_comparison
1	CPD	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Ranked	Low confidence	16	32	2
	LAMP1	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Measured		2399.5	543.5	4.4149
			Squared		1362.75	69.9153	19.4914
			Rooted		48.9847	23.3131	2.10117
	RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]	Measured	High confidence	450.5	2394.5	5.31521
			Squared		48.0356	1357.07	28.2513
			Rooted		21.225	48.9336	2.30547
	UBAC1	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Ranked		10	24	2.4
2	no value	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]			15	28	1.86667
	CDK4	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Measured	Low confidence	2399.5	543.5	4.4149
			Squared		1362.75	69.9153	19.4914
			Rooted		48.9847	23.3131	2.10117
	LAMP1	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Ranked		223	330	1.47982
	RHOBTB2	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Measured	High confidence	450.5	2394.5	5.31521
			Squared		48.0356	1357.07	28.2513
			Rooted		21.225	48.9336	2.30547
3	CDK4	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Ranked	Low confidence	223	330	1.47982
	CDK6	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Measured		2399.5	543.5	4.4149
			Squared		1362.75	69.9153	19.4914
			Rooted		48.9847	23.3131	2.10117
	HLX	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Measured	High confidence	2597.5	698.5	3.71868
			Squared		1596.92	115.48	13.8285
			Rooted		50.9657	26.4292	1.92839
	PSCD1	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Ranked		15	28	1.86667
4	CDK6	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]		Low confidence	223	330	1.47982
	HBS1L	hbs1-like. [refseq;acc:nm_006620]	Measured	High confidence	2597.5	698.5	3.71868
			Squared		1596.92	115.48	13.8285
			Rooted		50.9657	26.4292	1.92839
	LAMP2	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Measured	Low confidence	2399.5	543.5	4.4149
			Squared		1362.75	69.9153	19.4914
			Rooted		48.9847	23.3131	2.10117
	PSCD2	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Ranked	High confidence	15	28	1.86667
5	JPH3	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Measured		1153.5	339.5	3.39764
			Squared		314.926	27.2805	11.544
			Rooted		33.9632	18.4255	1.84327
	LAMP2	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Ranked	Low confidence	223	330	1.47982
	OSBPL6	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Measured		736.5	2113.5	2.86965
			Squared		128.386	1057.25	8.23493
			Rooted		27.1385	45.9728	1.69401
	PSCD4	cytohesin 4. [swissprot;acc:q9uia0]	Ranked	High confidence	15	28	1.86667
6	JPH2	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Measured		1153.5	339.5	3.39764
			Squared		314.926	27.2805	11.544
			Rooted		33.9632	18.4255	1.84327
	OSBPL3	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	Measured	Low confidence	736.5	2113.5	2.86965
			Squared		128.386	1057.25	8.23493
			Rooted		27.1385	45.9728	1.69401
	OSBPL6	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Ranked		318	240	1.325
	PSCD3	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]		High confidence	15	28	1.86667
7	HLX	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]			215	322	1.49767
	OSBPL3	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]		Low confidence	318	240	1.325

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.