MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Filtered	Rank	green	network_comparison	Interaction Map	Value Type	description	red	Network Comparison Type

Results: HTML CSV LaTeX

Showing element 501 to 550 of 38536 in total

Filtered  : 0
Network Comparison Type  : Divided

Rank	green	network_comparison	Interaction Map	Value Type	description	red
63	75.6508	2.03842	Low confidence	Measured	laminin beta-1 chain precursor (laminin b1 chain). [swissprot;acc:p07942]	154.208
	173.307	3.92038		Squared	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	44.2067
	11453	1.34428	High confidence	Ranked	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	8519.83
	15783.5	1.27551	Low confidence		60s ribosomal protein l37a. [swissprot;acc:p12751]	12374.3
64	15.2519	3.33542	High confidence	Squared	tyrosinase-related gene segment, exon 5 (fragment). [sptrembl;acc:q15677]	50.8715
	18	1800000		Measured	phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750]	0.00001
	22.5496	1.43422		Rooted	muscle-specific beta 1 integrin binding protein. [refseq;acc:nm_014446]	15.7225
	23.6984	2.03615	Low confidence	Measured	dna helicase homolog (fragment). [sptrembl;acc:q9y645]	48.2534
	66	1.44645		Rooted	anchor attachment protein 1; glycophosphatidylinositol anchor attachment 1; anchor attachment protein 1 (gaa1p, yeast) homolog. [refseq;acc:nm_003801]	45.6289
	173.244	3.88974		Squared	sedlin. [swissprot;acc:o14582]	44.5387
	11356	1.2736		Ranked	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	14463
	20387	1.33563	High confidence		similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	15264
65	0.00001	1800000		Measured	rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [refseq;acc:nm_007372]	18
	10.4958	1.43105	Low confidence	Rooted	transcription elongation factor a protein 1 (transcription elongation factor s-ii protein 1) (transcription elongation factor tfiis.o). [swissprot;acc:p23193]	7.33436
	15.1833	3.33538	High confidence	Squared	5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643]	50.642
	29.2291	1.42072		Rooted	60s ribosomal protein l21. [swissprot;acc:p46778]	20.5734
	47.3595	3.55848	Low confidence	Squared	l-lactate dehydrogenase a chain (ec 1.1.1.27) (ldh-a) (ldh muscle subunit) (ldh-m). [swissprot;acc:p00338]	13.3089
	923.065	1.98228		Measured	bet5 homolog (multiple myeloma protein 2) (mum-2). [swissprot;acc:q9y5r8]	465.658
	10406.3	1.32502	High confidence	Ranked	e1a binding protein p400; p400 swi2/snf2-related protein; cagh32 protein; trinucleotide repeat containing 12. [refseq;acc:nm_015409]	7853.67
	12943.5	1.27245	Low confidence		alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]	10172.1
66	21.9983	1.40854	High confidence	Rooted	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	30.9855
	26.828	1.4185	Low confidence		elongation of very long chain fatty acids protein 2. [swissprot;acc:q9nxb9]	18.9129
	127.516	3.47056		Squared	nadh-ubiquinone oxidoreductase mlrq subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-mlrq) (ci-mlrq). [swissprot;acc:o00483]	36.7422
	142.981	1.89874		Measured	tyrosinase-related gene segment, exon 5 (fragment). [sptrembl;acc:q15677]	271.484
	385.626	1.78524	High confidence		soluble liver antigen/liver pancreas antigen. [refseq;acc:nm_153825]	688.436
	558.241	3.2204		Squared	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	1797.76
	10030.4	1.26584	Low confidence	Ranked	kinesin-like protein kif13b (kinesin-like protein gakin). [swissprot;acc:q9nqt8]	7923.89
	15180	1.32449	High confidence		heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174]	11461
67	12.9538	1.41698	Low confidence	Rooted	alpha 2 globin. [refseq;acc:nm_000517]	18.3553
	15.2519	3.33542		Squared	tyrosinase-related gene segment, exon 5 (fragment). [sptrembl;acc:q15677]	50.8715
	15.3166	1.39177	High confidence	Rooted	isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252]	11.0051
	142.417	1.89769	Low confidence	Measured	5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643]	270.264
	190.865	3.1865	High confidence	Squared	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	608.191
	898	1.78508		Measured		1603
	14291.5	1.32408		Ranked	presenilin enhancer 2; hematopoietic stem/progenitor cells protein mds033. [refseq;acc:nm_172341]	10793.5
	14697.6	1.26309	Low confidence		dynamin-like 120 kda protein, mitochondrial precursor (optic atrophy 1 gene protein). [swissprot;acc:o60313]	11636.2
68	0.00001	3136000	High confidence	Squared	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	31.36
	8.63381	1.38766		Rooted	alpha crystallin a chain. [swissprot;acc:p02489]	6.22183
	12.9627	1.41651	Low confidence		hemoglobin gamma-a and gamma-g chains. [swissprot;acc:p02096]	18.3618
	15.1833	3.33538		Squared	5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (ec 1.14.18.-) (dhica oxidase) (tyrosinase-related protein 1) (trp-1) (trp1) (trp) (catalase b) (glycoprotein-75) (melanoma antigen gp75). [swissprot;acc:p17643]	50.642
	351.772	1.76802	High confidence	Measured	protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [refseq;acc:nm_003981]	198.964
	734	1.86294	Low confidence		nadh-ubiquinone oxidoreductase mlrq subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-mlrq) (ci-mlrq). [swissprot;acc:o00483]	394
	9824.6	1.25899		Ranked	repressor of estrogen receptor activity; b-cell associated protein. [refseq;acc:nm_007273]	7803.58
	11823.3	1.32362	High confidence		purine nucleoside phosphorylase (ec 2.4.2.1) (inosine phosphorylase) (pnp). [swissprot;acc:p00491]	8932.56
69	12.9659	1.41635	Low confidence	Rooted	myoglobin. [swissprot;acc:p02144]	18.3642
	13.5207	1.38596	High confidence		cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	18.7392
	50.7408	3.12432		Squared	protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [refseq;acc:nm_003981]	16.2406
	70.5	1.82979	Low confidence	Measured	tubulointerstitial nephritis antigen. [refseq;acc:nm_014464]	129
	253.857	3.26573		Squared	tolloid-like 1. [refseq;acc:nm_012464]	77.7335
	2804	1.7602	High confidence	Measured	dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]	1593

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.