MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Value Type	green	Gene	Rank	Network Comparison Type	Interaction Map	Filtered	red	network_comparison

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Showing element 51 to 100 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

description	Value Type	green	Rank	red	network_comparison
15 kda selenoprotein precursor. [swissprot;acc:o60613]	Squared	34456.5	914	29772.1	1.15734
	Rooted	67.2624	1334	64.5959	1.04128
15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [swissprot;acc:p15428]	Measured	0.00001	2855	0.00001	1
	Ranked
	Squared
	Rooted
17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]	Measured	6113.96	2521	5964.17	1.02511
	Ranked	217.998	1051	211.449	1.03097
	Squared	27574.1	2377	25809.5	1.06837
	Rooted	63.5847	2642	63.9773	1.00617
2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83]	Measured	6192.72	1393	5743.36	1.07824
	Ranked	222.969	2007	225.019	1.00919
	Squared	32473.8	1593	29261.2	1.10979
	Rooted	62.6331	1463	60.3015	1.03867
2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	Measured	6362.25	2506	6200.39	1.0261
	Ranked	214.041	1160	208.55	1.02633
	Squared	28847.4	2426	27135.1	1.0631
	Rooted	65.1252	2700	65.3323	1.00318
2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [swissprot;acc:p12694]	Measured	6957.34	2451	6737.15	1.03268
	Ranked	202.726	1484	198.927	1.0191
	Squared	31699.9	1699	28693.8	1.10476
	Rooted	69.1987	2716	69.1013	1.00141
2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [swissprot;acc:p21953]	Measured	6048.94	2288	5783.76	1.04585
	Ranked	213.875	1389	218.47	1.02148
	Squared	26643.2	2488	25184.8	1.05791
	Rooted	64.1938	1579	61.9705	1.03588
20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	Measured	5843.51	107	4266.04	1.36977
	Ranked	198.011	183	228.306	1.153
	Squared	20126.8	290	15734.4	1.27916
	Rooted	66.6101	135	54.935	1.21253
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	Measured	0.00001	3079	0.00001	1
	Ranked
	Squared
	Rooted
26s protease regulatory subunit 4 (p26s4). [swissprot;acc:q03527]	Measured	6376.76	1521	5938.56	1.07379
	Ranked	216.137	2503	215.581	1.00258
	Squared	30104.4	1644	27191.5	1.10713
	Rooted	64.7621	1870	62.901	1.02959
26s protease regulatory subunit 6a (tat-binding protein 1) (tbp-1) (proteasome subunit p50). [swissprot;acc:p17980]	Measured	6362.33	1527	5926.76	1.07349
	Ranked	217.285	2474	216.64	1.00298
	Squared	30410	1496	27295.8	1.11409
	Rooted	64.4831	1916	62.679	1.02878
26s protease regulatory subunit 6b (mip224) (mb67 interacting protein) (tat-binding protein-7) (tbp-7). [swissprot;acc:p43686]	Measured	6242.94	1567	5822.25	1.07226
	Ranked	218.426	2327	217.413	1.00466
	Squared	29299.3	1489	26277.3	1.115
	Rooted	63.9055	2044	62.2342	1.02686
26s protease regulatory subunit 7 (mss1 protein). [swissprot;acc:p35998]	Measured	6207.5	1539	5783.97	1.07322
	Ranked	219.014	2395	218.192	1.00377
	Squared	29163.8	1481	26142.6	1.11557
	Rooted	63.6738	1979	61.9542	1.02776

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.