MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	Value Type	description	Filtered	Network Comparison Type	Interaction Map	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 101 to 150 of 77072 in total

Rank	Value Type	description	Filtered	Network Comparison Type	Interaction Map	green	red	network_comparison
4	Measured	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	0	Divided	Low confidence	89	0.00001	8900000
		homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]			High confidence
		lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	1		Low confidence	543.5	2399.5	4.4149
		small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	0	Subtracted	High confidence	21730	18704	3026
	Ranked	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	1	Divided	Low confidence	330	223	1.47982
		cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]			High confidence	28	15	1.86667
		lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]		Subtracted	Low confidence	330	223	107
		mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	0	Divided	High confidence	21883	8906	2.45711
		mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]		Subtracted	Low confidence	14977	5865	9112
		neurogenic locus notch homolog protein 2 precursor (notch 2) (hn2). [swissprot;acc:q04721]		Divided		20617	9607	2.14604
		nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]		Subtracted	High confidence	21888	11525	10363
		rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	1			232	337	105
	Squared	cytochrome c oxidase polypeptide viic, mitochondrial precursor (ec 1.9.3.1). [swissprot;acc:p15954]	0		Low confidence	295570	273831	21739
		cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	1		High confidence	263351	407289	143938
		guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]	0	Divided	Low confidence	0.823905	0.00001	82390.5
		hbs1-like. [refseq;acc:nm_006620]	1		High confidence	115.48	1596.92	13.8285
		lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]			Low confidence	69.9153	1362.75	19.4914
		nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]		Subtracted		473408	332411	140997
		pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]	0	Divided	High confidence	2.81207	0.00001	281207
		similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]		Subtracted		105900	75446.7	30453.3
	Rooted	hbs1-like. [refseq;acc:nm_006620]	1	Divided		26.4292	50.9657	1.92839
				Subtracted				24.5365
		homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	0	Divided	Low confidence	9.43398	0.00001	943398
		lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	1			23.3131	48.9847	2.10117
				Subtracted				25.6716
		mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	0			0	19.0788	19.0788
		mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]			High confidence	7.61577	29.3087	21.6929
		pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]		Divided		10.4403	0.00001	1044030
5	Measured	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	1	Subtracted		33356.5	41482.5	8126
		histone h4. [swissprot;acc:p02304]	0			24446.3	21773.1	2673.2
		homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]		Divided		89	0.00001	8900000
		jumonji protein. [swissprot;acc:q92833]			Low confidence	17.5166		1751660
		junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	1		High confidence	339.5	1153.5	3.39764
		lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	0	Subtracted	Low confidence	2740.13	485.286	2254.84
		oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	1	Divided		2113.5	736.5	2.86965
		vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]		Subtracted		43503.3	36469.3	7034
	Ranked	cytohesin 4. [swissprot;acc:q9uia0]		Divided	High confidence	28	15	1.86667
		homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	0	Subtracted	Low confidence	13216	22286	9070
		lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	1	Divided		330	223	1.47982
		oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]		Subtracted		240	318	78
		transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [swissprot;acc:q9bq87]	0		High confidence	21888	11525	10363
		ubiquitin-like protein smt3b (sentrin 2) (hsmt3). [swissprot;acc:p55855]		Divided		11965.7	5510.5	2.17144
		ubiquitously transcribed y chromosome tetratricopeptide repeat protein (ubiquitously transcribed tpr protein on the y chromosome). [swissprot;acc:o14607]			Low confidence	19873	10889.4	1.82499
		xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	1	Subtracted	High confidence	309	212	97
	Squared	carbohydrate (n-acetylglucosamine 6-o) sulfotransferase 6; macular dystrophy, corneal, 1; carbohydate sulfotransferase 6; corneal n-acetylglucosamine 6-sulfotransferase. [refseq;acc:nm_021615]	0	Divided	Low confidence	0.00001	0.324024	32402.4
		cytohesin 4. [swissprot;acc:q9uia0]	1	Subtracted	High confidence	263351	407289	143938
		ena/vasodilator stimulated phosphoprotein-like protein (ena/vasp-like protein). [swissprot;acc:q9ui08]	0		Low confidence	59791.4	40110.9	19680.5
		homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]		Divided	High confidence	1.87479	0.00001	187479
		junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	1			27.2805	314.926	11.544
		oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]			Low confidence	1057.25	128.386	8.23493

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.