MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Value Type	Rank	green	Filtered	description	Network Comparison Type	network_comparison	Interaction Map	red

Results: HTML CSV LaTeX

Showing element 1 to 50 of 38536 in total

Value Type  : Measured
Network Comparison Type  : Divided

Rank	green	Filtered	description	network_comparison	Interaction Map	red
1	0.00001	0	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	36400000	High confidence	364
					Low confidence
	543.5	1	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	4.4149		2399.5
	2394.5		rad50-interacting protein 1. [refseq;acc:nm_021930]	5.31521	High confidence	450.5
2	89	0	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	8900000	Low confidence	0.00001
	174		cab2. [refseq;acc:nm_033419]	17400000	High confidence
	543.5	1	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	4.4149	Low confidence	2399.5
	2394.5		rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	5.31521	High confidence	450.5
3	89	0	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	8900000	Low confidence	0.00001
	109		pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]	10900000	High confidence
	543.5	1	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	4.4149	Low confidence	2399.5
	698.5		homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	3.71868	High confidence	2597.5
4	89	0	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	8900000	Low confidence	0.00001
			homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]		High confidence
	543.5	1	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	4.4149	Low confidence	2399.5
	698.5		hbs1-like. [refseq;acc:nm_006620]	3.71868	High confidence	2597.5
5	17.5166	0	jumonji protein. [swissprot;acc:q92833]	1751660	Low confidence	0.00001
	89		homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	8900000	High confidence
	339.5	1	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	3.39764		1153.5
	2113.5		oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	2.86965	Low confidence	736.5
6	0.00001	0	homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]	1300000		13
	89		homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	8900000	High confidence	0.00001
	339.5	1	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	3.39764		1153.5
	2113.5		oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	2.86965	Low confidence	736.5
7	0.00001	0	tbc1 domain family, member 8 (with gram domain); vascular rab-gap/tbc-containing. [refseq;acc:nm_007063]	231962		2.31962
	43		sedlin. [swissprot;acc:o14582]	4300000	High confidence	0.00001
	339.5	1	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	3.39764		1153.5
	2113.5		oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	2.86965	Low confidence	736.5
8	43	0	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	4300000	High confidence	0.00001
	339.5	1	db83 protein. [swissprot;acc:p57088]	3.39764		1153.5
	5058.5		phosphatidylinositol-glycan biosynthesis, class f protein (pig-f). [swissprot;acc:q07326]	1.54317	Low confidence	3278
	6410	0	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	75.4118		85
9	10.6048		ubiquitously transcribed y chromosome tetratricopeptide repeat protein (ubiquitously transcribed tpr protein on the y chromosome). [swissprot;acc:o14607]	36.1876		383.762
	1281.5	1	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	3.21581	High confidence	398.5
	5058.5		n33 protein. [swissprot;acc:q13454]	1.54317	Low confidence	3278
	6410	0	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	75.4118	High confidence	85
10	5.56738		serpin b12. [swissprot;acc:q96p63]	35.8425	Low confidence	199.549
	1281.5	1	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	3.21581	High confidence	398.5
	5058.5		implantation-associated protein. [refseq;acc:nm_032121]	1.54317	Low confidence	3278
	6410	0	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	75.4118	High confidence	85
11	5.56738		serpin b12. [swissprot;acc:q96p63]	35.8425		199.549
	5.71669		hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	34.8539	Low confidence	199.249
	1281.5	1	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	3.21581	High confidence	398.5
	2950.5		thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	1.53861	Low confidence	1917.64
12	5.71669	0	hurpin (hacat uv-repressible serpin) (protease inhibitor 13) (headpin) (serpin b13). [swissprot;acc:q9uiv8]	34.8539	High confidence	199.249
	58		mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	14.8103	Low confidence	859
	1281.5	1	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	3.21581	High confidence	398.5
	2954.24		gbp protein isoform a. [refseq;acc:nm_017870]	1.5371	Low confidence	1921.96
13	47	0	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	29	High confidence	1363
	115.385		fk506-binding protein 6 (ec 5.2.1.8) (peptidyl-prolyl cis-trans isomerase) (ppiase) (rotamase) (36 kda fk506 binding protein) (fkbp- 36) (immunophilin fkbp36). [swissprot;acc:o75344]	14.21	Low confidence	8.11997

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.