MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Filtered	green	Value Type	Gene	network_comparison	red	Interaction Map	Network Comparison Type	Rank	description

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Showing element 1 to 32 of 32 in total

Rank  : 8

Filtered	green	Value Type	network_comparison	red	Interaction Map	Network Comparison Type	description
0	0.00001	Squared	159148	1.59148	High confidence	Divided	ero1-like. [refseq;acc:nm_014584]
		Rooted	360555	3.60555	Low confidence		homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]
			905539	9.05539	High confidence		ero1-like. [refseq;acc:nm_014584]
	43	Measured	4300000	0.00001			synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]
	56.7758	Rooted	15.3379	72.1137		Subtracted	nif3-like protein 1 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 1) (my018 protein) (mds015). [swissprot;acc:q9gzt8]
	111.067		15.292	126.359	Low confidence		nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]
	6410	Measured	75.4118	85		Divided	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]
	7500.75		2393.82	5106.93	High confidence	Subtracted	nucleoporin nup43 (p42). [swissprot;acc:q8nfh3]
	8770.72		1232.83	7537.89	Low confidence		zinc finger protein 277. [swissprot;acc:q9nrm2]
	13216	Ranked	1.68629	22286		Divided	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]
			9070		High confidence	Subtracted	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]
	19295.9	Squared	11098	1.73869	Low confidence	Divided	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]
	19873	Ranked	8983.6	10889.4		Subtracted	ubiquitously transcribed y chromosome tetratricopeptide repeat protein (ubiquitously transcribed tpr protein on the y chromosome). [swissprot;acc:o14607]
	21888		1.89918	11525	High confidence	Divided	nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [swissprot;acc:q9bzk7]
	61843.5	Squared	16419.5	45424	Low confidence	Subtracted	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]
	386144		28560	414704	High confidence		transcription initiation factor tfiid 135 kda subunit (tafii-135) (tafii135) (tafii-130) (tafii130). [swissprot;acc:o00268]
1	18.4255	Rooted	1.84327	33.9632		Divided	db83 protein. [swissprot;acc:p57088]
	27.2805	Squared	11.544	314.926
	45.9728	Rooted	18.8343	27.1385	Low confidence	Subtracted	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]
	47.6922		1.49674	31.8641		Divided	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]
	168.796		23.245	145.551	High confidence	Subtracted	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]
	240	Ranked	1.325	318	Low confidence	Divided	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]
	247.246		58.226	305.472		Subtracted	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]
	322		1.49767	215	High confidence	Divided	hbs1-like. [refseq;acc:nm_006620]
	339.5	Measured	3.39764	1153.5			db83 protein. [swissprot;acc:p57088]
	362	Ranked	74	288		Subtracted	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]
	5058.5	Measured	1.54317	3278	Low confidence	Divided	phosphatidylinositol-glycan biosynthesis, class f protein (pig-f). [swissprot;acc:q07326]
	6056.43	Squared	2.38136	2543.26
	28492	Measured	7307	21185	High confidence	Subtracted	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]
	39358.1		6246.7	33111.4	Low confidence		deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]
	192141	Squared	85915	106226			mitochondrial solute carrier protein. [refseq;acc:nm_145305]
	354894		104591	250303	High confidence		deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.