MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	green	Value Type	Gene	Rank	Network Comparison Type	Interaction Map	Filtered	red	network_comparison

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Showing element 51 to 100 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

description	green	Value Type	Rank	red	network_comparison
15 kda selenoprotein precursor. [swissprot;acc:o60613]	6933.36	Measured	1043	6344.41	1.09283
	34456.5	Squared	914	29772.1	1.15734
15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [swissprot;acc:p15428]	0.00001	Measured	2855	0.00001	1
		Ranked
		Squared
		Rooted
17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]	63.5847		2642	63.9773	1.00617
	217.998	Ranked	1051	211.449	1.03097
	6113.96	Measured	2521	5964.17	1.02511
	27574.1	Squared	2377	25809.5	1.06837
2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83]	62.6331	Rooted	1463	60.3015	1.03867
	222.969	Ranked	2007	225.019	1.00919
	6192.72	Measured	1393	5743.36	1.07824
	32473.8	Squared	1593	29261.2	1.10979
2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	65.1252	Rooted	2700	65.3323	1.00318
	214.041	Ranked	1160	208.55	1.02633
	6362.25	Measured	2506	6200.39	1.0261
	28847.4	Squared	2426	27135.1	1.0631
2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [swissprot;acc:p12694]	69.1987	Rooted	2716	69.1013	1.00141
	202.726	Ranked	1484	198.927	1.0191
	6957.34	Measured	2451	6737.15	1.03268
	31699.9	Squared	1699	28693.8	1.10476
2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [swissprot;acc:p21953]	64.1938	Rooted	1579	61.9705	1.03588
	213.875	Ranked	1389	218.47	1.02148
	6048.94	Measured	2288	5783.76	1.04585
	26643.2	Squared	2488	25184.8	1.05791
20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	66.6101	Rooted	135	54.935	1.21253
	198.011	Ranked	183	228.306	1.153
	5843.51	Measured	107	4266.04	1.36977
	20126.8	Squared	290	15734.4	1.27916
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	0.00001	Measured	3079	0.00001	1
		Ranked
		Squared
		Rooted
26s protease regulatory subunit 4 (p26s4). [swissprot;acc:q03527]	64.7621		1870	62.901	1.02959
	216.137	Ranked	2503	215.581	1.00258
	6376.76	Measured	1521	5938.56	1.07379
	30104.4	Squared	1644	27191.5	1.10713
26s protease regulatory subunit 6a (tat-binding protein 1) (tbp-1) (proteasome subunit p50). [swissprot;acc:p17980]	64.4831	Rooted	1916	62.679	1.02878
	217.285	Ranked	2474	216.64	1.00298
	6362.33	Measured	1527	5926.76	1.07349
	30410	Squared	1496	27295.8	1.11409
26s protease regulatory subunit 6b (mip224) (mb67 interacting protein) (tat-binding protein-7) (tbp-7). [swissprot;acc:p43686]	63.9055	Rooted	2044	62.2342	1.02686
	218.426	Ranked	2327	217.413	1.00466
	6242.94	Measured	1567	5822.25	1.07226
	29299.3	Squared	1489	26277.3	1.115
26s protease regulatory subunit 7 (mss1 protein). [swissprot;acc:p35998]	63.6738	Rooted	1979	61.9542	1.02776
	219.014	Ranked	2395	218.192	1.00377
	6207.5	Measured	1539	5783.97	1.07322
	29163.8	Squared	1481	26142.6	1.11557

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.