MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	Network Comparison Type	red	green	network_comparison
1	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Ranked	Subtracted	215	322	107
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Measured		41482.5	33356.5	8126
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Ranked	Divided	10	24	2.4
		Squared	Subtracted	468498	322755	145743
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Measured	Divided	450.5	2394.5	5.31521
		Squared		48.0356	1357.07	28.2513
		Rooted		21.225	48.9336	2.30547
			Subtracted			27.7086
2	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Measured		41482.5	33356.5	8126
	hbs1-like. [refseq;acc:nm_006620]	Ranked		215	322	107
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]		Divided	15	28	1.86667
		Squared	Subtracted	407289	263351	143938
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Measured	Divided	450.5	2394.5	5.31521
		Squared		48.0356	1357.07	28.2513
		Rooted		21.225	48.9336	2.30547
			Subtracted			27.7086
3	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Ranked	Divided	15	28	1.86667
		Squared	Subtracted	407289	263351	143938
	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Measured		41482.5	33356.5	8126
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]		Divided	2597.5	698.5	3.71868
		Squared		1596.92	115.48	13.8285
		Rooted		50.9657	26.4292	1.92839
			Subtracted			24.5365
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Ranked		337	232	105
4	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]		Divided	15	28	1.86667
		Squared	Subtracted	407289	263351	143938
	cytohesin 4. [swissprot;acc:q9uia0]	Measured		41482.5	33356.5	8126
	hbs1-like. [refseq;acc:nm_006620]		Divided	2597.5	698.5	3.71868
		Squared		1596.92	115.48	13.8285
		Rooted		50.9657	26.4292	1.92839
			Subtracted			24.5365
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Ranked		337	232	105
5	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Rooted		145.551	168.796	23.245
	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Measured		41482.5	33356.5	8126
	cytohesin 4. [swissprot;acc:q9uia0]	Ranked	Divided	15	28	1.86667
		Squared	Subtracted	407289	263351	143938
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Measured	Divided	1153.5	339.5	3.39764
		Squared		314.926	27.2805	11.544
		Rooted		33.9632	18.4255	1.84327
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Ranked	Subtracted	212	309	97
6	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]		Divided	15	28	1.86667
		Squared	Subtracted	407289	263351	143938
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Measured	Divided	1153.5	339.5	3.39764
		Squared		314.926	27.2805	11.544
		Rooted		33.9632	18.4255	1.84327
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]		Subtracted	145.551	168.796	23.245
	protein x 0004. [refseq;acc:nm_016301]	Ranked		212	309	97
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Measured		44490.5	36927.5	7563
7	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]			21185	28492	7307
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Ranked	Divided	215	322	1.49767

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.