MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Hugo	Network Comparison Type	red	Value Type	Interaction Map	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Hugo	red	Value Type	Interaction Map	green	network_comparison
1	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	CPD	16	Ranked	Low confidence	32	2
	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	LAMP1	48.9847	Rooted		23.3131	2.10117
			1362.75	Squared		69.9153	19.4914
			2399.5	Measured		543.5	4.4149
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	UBAC1	10	Ranked	High confidence	24	2.4
	rad50-interacting protein 1. [refseq;acc:nm_021930]	RINT1	21.225	Rooted		48.9336	2.30547
			48.0356	Squared		1357.07	28.2513
			450.5	Measured		2394.5	5.31521
2	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	CDK4	48.9847	Rooted	Low confidence	23.3131	2.10117
			1362.75	Squared		69.9153	19.4914
			2399.5	Measured		543.5	4.4149
	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	LAMP1	223	Ranked		330	1.47982
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	no value	15		High confidence	28	1.86667
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	RHOBTB2	21.225	Rooted		48.9336	2.30547
			48.0356	Squared		1357.07	28.2513
			450.5	Measured		2394.5	5.31521
3	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	CDK4	223	Ranked	Low confidence	330	1.47982
	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	CDK6	48.9847	Rooted		23.3131	2.10117
			1362.75	Squared		69.9153	19.4914
			2399.5	Measured		543.5	4.4149
	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	PSCD1	15	Ranked	High confidence	28	1.86667
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	HLX	50.9657	Rooted		26.4292	1.92839
			1596.92	Squared		115.48	13.8285
			2597.5	Measured		698.5	3.71868
4	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	CDK6	223	Ranked	Low confidence	330	1.47982
	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	PSCD2	15		High confidence	28	1.86667
	hbs1-like. [refseq;acc:nm_006620]	HBS1L	50.9657	Rooted		26.4292	1.92839
			1596.92	Squared		115.48	13.8285
			2597.5	Measured		698.5	3.71868
	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	LAMP2	48.9847	Rooted	Low confidence	23.3131	2.10117
			1362.75	Squared		69.9153	19.4914
			2399.5	Measured		543.5	4.4149
5	cytohesin 4. [swissprot;acc:q9uia0]	PSCD4	15	Ranked	High confidence	28	1.86667
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	JPH3	33.9632	Rooted		18.4255	1.84327
			314.926	Squared		27.2805	11.544
			1153.5	Measured		339.5	3.39764
	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	LAMP2	223	Ranked	Low confidence	330	1.47982
	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	OSBPL6	27.1385	Rooted		45.9728	1.69401
			128.386	Squared		1057.25	8.23493
			736.5	Measured		2113.5	2.86965
6	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	PSCD3	15	Ranked	High confidence	28	1.86667
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	JPH2	33.9632	Rooted		18.4255	1.84327
			314.926	Squared		27.2805	11.544
			1153.5	Measured		339.5	3.39764
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	OSBPL3	27.1385	Rooted	Low confidence	45.9728	1.69401
			128.386	Squared		1057.25	8.23493
			736.5	Measured		2113.5	2.86965
	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	OSBPL6	318	Ranked		240	1.325
7	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	HLX	215		High confidence	322	1.49767
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	OSBPL3	318		Low confidence	240	1.325

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.