MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Network Comparison Type	Gene	Rank	Value Type	Hugo	Interaction Map	Filtered	red	network_comparison	green

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Showing element 1 to 50 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Hugo	red	network_comparison	green
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Divided	18	GBE1	185.678	1.32082	245.247
	Subtracted	54			59.569
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	Divided	1038	no value	186.741	1.03148	181.041
	Subtracted	1120			5.7
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	Divided	1032	AGPAT2	186.664	1.03162	180.943
	Subtracted	1115			5.721
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	Divided	1048	AGPAT4	187.96	1.031	182.308
	Subtracted	1128			5.652
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	Divided	1043	AGPAT3	187.834	1.03128	182.137
	Subtracted	1121			5.697
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	Divided	3126	PLCB4	0.00001	1	0.00001
	Subtracted			0	0	0
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	Divided	1963	HSPE1	211.633	1.00978	213.703
	Subtracted	1933			2.07
10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]	Divided	2922	ALDH1L1	0.00001	1	0.00001
	Subtracted			0	0	0
14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946]	Divided	2439	YWHAB	220.681	1.00337	221.425
	Subtracted	2421			0.744
14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655]	Divided	3088	YWHAE	0.00001	1	0.00001
	Subtracted			0	0	0
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312]	Divided	2396	YWHAZ	220.683	1.00375	221.51
	Subtracted	2391			0.827
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758]	Divided	2366	HRSP12	203.353	1.00407	202.529
	Subtracted	2393			0.824
15 kda selenoprotein precursor. [swissprot;acc:o60613]	Divided	1948	no value	214.522	1.00984	212.432
	Subtracted	1920			2.09
15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [swissprot;acc:p15428]	Divided	2855	HPGD	0.00001	1	0.00001
	Subtracted			0	0	0
17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]	Divided	1051	no value	211.449	1.03097	217.998
	Subtracted	1029			6.549
2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83]	Divided	2007	HACL1	225.019	1.00919	222.969
	Subtracted	1954			2.05
2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	Divided	1160	OGDH	208.55	1.02633	214.041
	Subtracted	1164			5.491
2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [swissprot;acc:p12694]	Divided	1484	TMEM91	198.927	1.0191	202.726
	Subtracted	1515			3.799
2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [swissprot;acc:p21953]	Divided	1389	BCKDHB	218.47	1.02148	213.875
	Subtracted	1336			4.595
20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	Divided	183	NCBP2	228.306	1.153	198.011
	Subtracted	140			30.295
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	Divided	3079	CYP27B1	0.00001	1	0.00001
	Subtracted			0	0	0
26s protease regulatory subunit 4 (p26s4). [swissprot;acc:q03527]	Divided	2503	PSMC1	215.581	1.00258	216.137
	Subtracted	2497			0.556
26s protease regulatory subunit 6a (tat-binding protein 1) (tbp-1) (proteasome subunit p50). [swissprot;acc:p17980]	Divided	2474	PSMC3	216.64	1.00298	217.285
	Subtracted	2466			0.645
26s protease regulatory subunit 6b (mip224) (mb67 interacting protein) (tat-binding protein-7) (tbp-7). [swissprot;acc:p43686]	Divided	2327	PSMC4	217.413	1.00466	218.426
	Subtracted	2323			1.013
26s protease regulatory subunit 7 (mss1 protein). [swissprot;acc:p35998]	Divided	2395	PSMC2	218.192	1.00377	219.014
	Subtracted	2394			0.822

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.