MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 463 to 512 of 7460 in total

Value Type  : Ranked
Interaction Map  : High confidence

Rank	description	Network Comparison Type	Filtered	red	green	network_comparison
116	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	Subtracted	1	208.52	171.595	36.925
	metaxin 1. [swissprot;acc:q13505]	Divided	0	13761.3	16422.1	1.19335
117	basic proline-rich peptide p-e (ib-9). [swissprot;acc:p02811]			11545	13771.5	1.19285
	block 23. [sptrembl;acc:q8nhw5]	Subtracted		11469.3	13334.8	1865.5
	high-mobility group 20a. [refseq;acc:nm_018200]		1	208.588	171.778	36.81
	neuralized-like. [refseq;acc:nm_004210]	Divided		332.326	266.948	1.24491
118	aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]		0	12049	14370.7	1.19269
	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	Subtracted		3845	5699	1854
	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	Divided	1	284.753	228.934	1.24382
	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	Subtracted		274.027	237.79	36.237
119	adiponectin receptor 2. [refseq;acc:nm_024551]			281.582	246.371	35.211
	mesoderm induction early response 1. [refseq;acc:nm_020948]	Divided	0	3609	4302.5	1.19216
	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]		1	318.982	259.004	1.23157
	pms1 protein homolog 2 (dna mismatch repair protein pms2). [swissprot;acc:p54278]	Subtracted	0	7739.47	9580.95	1841.48
120	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]		1	227.199	192.715	34.484
	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	Divided		269.278	327.709	1.21699
	presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]		0	5797	4873	1.18962
	similar to ribosomal protein, large, p0. [sptrembl;acc:q96fq9]	Subtracted		11438	13277.1	1839.1
121	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]	Divided	1	269.254	327.655	1.2169
	metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832]	Subtracted	0	18241.7	16405	1836.7
	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]		1	227.202	192.823	34.379
	zinc finger protein 232. [swissprot;acc:q9uny5]	Divided	0	11523.7	13686.9	1.18772
122	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	Subtracted	1	199.949	234.187	34.238
	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]		0	12384.7	10549.4	1835.3
	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	Divided	1	269.248	327.642	1.21688
	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]		0	11523	13685.4	1.18766
123	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]	Subtracted		12335.3	10506.8	1828.5
	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	Divided	1	269.23	327.601	1.21681
	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	Subtracted		227.032	193.056	33.976
	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]	Divided	0	11522.8	13684.9	1.18764
124	cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6]	Subtracted		12328.5	10501	1827.5
	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	Divided	1	208.52	171.595	1.21519
	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	Subtracted		285.684	252.234	33.45
	zinc finger imprinted 2. [swissprot;acc:q9nzv7]	Divided	0	11520.7	13680.4	1.18746
125	cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]	Subtracted		12314.9	10489.3	1825.6
	high-mobility group 20a. [refseq;acc:nm_018200]	Divided	1	208.588	171.778	1.21429
	phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750]		0	22038	18578	1.18624
	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	Subtracted	1	285.684	252.234	33.45
126	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	Divided		94	114	1.21277
	cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329]	Subtracted	0	12314.9	10489.3	1825.6
	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]		1	285.684	252.234	33.45
	ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]	Divided	0	9722.71	11493.8	1.18216
127	ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]	Subtracted		11732	13530.6	1798.6
	cullin homolog 2 (cul-2). [swissprot;acc:q13617]		1	285.684	252.234	33.45
	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]	Divided		94	114	1.21277
	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]		0	9411.34	11119.7	1.18152
128	60s ribosomal protein l39. [swissprot;acc:p02404]			11564.4	9794.29	1.18073
	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]		1	94	114	1.21277
	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	Subtracted		285.684	252.234	33.45
	ret finger protein 2 (leukemia associated protein 5) (b-cell chronic lymphocytic leukemia tumor suppressor leu5) (putative tumor suppressor rfp2) (tripartite motif protein 13). [swissprot;acc:o60858]		0	9722.71	11493.8	1771.09

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.