MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1677 to 1726 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
839	dna directed rna polymerase ii polypeptide j-related gene isoform 1; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_145325]	Subtracted	230.764	239.62	8.856
	stem cell growth factor; lymphocyte secreted c-type lectin; lymphocyte secreted c-type lectin. [refseq;acc:nm_002975]	Divided	177.776	170.499	1.04268
840	deformed epidermal autoregulatory factor 1 homolog (nuclear deaf-1 related transcriptional regulator) (nudr) (suppressin) (zinc finger mynd domain containing protein 5). [swissprot;acc:o75398]	Subtracted	236.741	245.547	8.806
	mitochondrial import receptor subunit tom20 homolog (mitochondrial 20 kda outer membrane protein) (outer mitochondrial membrane receptor tom20). [swissprot;acc:q15388]	Divided	198.781	190.66	1.04259
841	peroxisomal farnesylated protein (33 kda housekeeping protein) (peroxin 19). [swissprot;acc:p40855]
	rio kinase 1 isoform 1; ad034 protein. [refseq;acc:nm_031480]	Subtracted	236.741	245.547	8.806
842	jm1 protein. [refseq;acc:nm_014008]	Divided	219.762	210.806	1.04248
	map/microtubule affinity-regulating kinase 1. [refseq;acc:nm_018650]	Subtracted	236.741	245.547	8.806
843	map/microtubule affinity-regulating kinase 2 isoform b; elkl motif kinase 1; elkl motif kinase. [refseq;acc:nm_004954]
	trifunctional purine biosynthetic protein adenosine-3 [includes: phosphoribosylamine--glycine ligase (ec 6.3.4.13) (gars) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase); phosphoribosylformylglycinamidine cyclo-ligase (ec 6.3.3.1) (airs) (phosphoribosyl-aminoimidazole synthetase) (air synthase); phosphoribosylglycinamide formyltransferase (ec 2.1.2.2) (gart) (gar transformylase) (5'-phosphoribosylglycinamide transformylase)]. [swissprot;acc:p22102]	Divided	218.521	227.796	1.04244
844	c-type lectin superfamily member 1 precursor (cartilage-derived c-type lectin). [swissprot;acc:o75596]		178.033	170.82	1.04223
	meiotic recombination protein spo11. [swissprot;acc:q9y5k1]	Subtracted	236.741	245.547	8.806
845	hydroxyacid oxidase 2 (ec 1.1.3.15) (haox2) ((s)-2-hydroxy-acid oxidase, peroxisomal) (long chain alpha-hydroxy acid oxidase) (long- chain l-2-hydroxy acid oxidase). [swissprot;acc:q9nyq3]		232.512	241.288	8.776
	u6 snrna-associated sm-like protein lsm1 (small nuclear ribonuclear casm) (cancer-associated sm-like). [swissprot;acc:o15116]	Divided	228.599	219.399	1.04193
846	methyltransferase like 2. [refseq;acc:nm_018396]		147.211	153.371	1.04184
	parafibromin. [refseq;acc:nm_024529]	Subtracted	239.704	230.991	8.713
847	cytoplasmic dynein light chain (t-complex testis-specific protein 1 homolog) (protein cw-1). [swissprot;acc:q15763]	Divided	147.211	153.371	1.04184
	l-myc-1 proto-oncogene protein. [swissprot;acc:p12524]	Subtracted	227.604	219.001	8.603
848	fzr1 protein; fizzy-related protein; cdc20-like 1b. [refseq;acc:nm_016263]	Divided	147.211	153.371	1.04184
	wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516]	Subtracted	206.214	197.614	8.6
849	proprotein convertase subtilisin/kexin type 5 precursor (ec 3.4.21.-) (proprotein convertase pc5) (subtilisin/kexin-like protease pc5) (convertase pc5) (pc6) (hpc6). [swissprot;acc:q92824]	Divided	147.211	153.371	1.04184
	transcription factor iib. [refseq;acc:nm_013242]	Subtracted	206.068	197.471	8.597
850	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	Divided	107.842	112.329	1.04161
	splicing factor, arginine/serine-rich 8 (suppressor of white apricot protein homolog). [swissprot;acc:q12872]	Subtracted	206.068	197.471	8.597
851	n-myc proto-oncogene protein. [swissprot;acc:p04198]		227.601	219.008	8.593
	trs85 homolog. [swissprot;acc:q9y2l5]	Divided	107.842	112.329	1.04161
852	ga binding protein alpha chain (gabp-alpha subunit) (transcription factor e4tf1-60) (nuclear respiratory factor-2 subunit alpha). [swissprot;acc:q06546]	Subtracted	227.596	219.017	8.579
	hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [swissprot;acc:p00492]	Divided	193.114	185.412	1.04154
853	ga binding protein beta-2 chain (gabp-beta-2 subunit) (transcription factor e4tf1-47) (gapbp-2) (nuclear respiratory factor-2 subunit gamma). [swissprot;acc:q06545]	Subtracted	227.596	219.017	8.579
	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	Divided	108.289	112.772	1.0414
854	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]
	nadh-ubiquinone oxidoreductase 23 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-23kd) (ci-23kd) (tyky subunit). [swissprot;acc:o00217]	Subtracted	227.596	219.017	8.579
855	elongation of very long chain fatty acids protein 1 (cgi-88). [swissprot;acc:q9bw60]			219.018	8.578
	tetranectin precursor (tn) (plasminogen-kringle 4 binding protein). [swissprot;acc:p05452]	Divided	178.514	171.42	1.04138
856	myc proto-oncogene protein (c-myc). [swissprot;acc:p01106]	Subtracted	227.585	219.037	8.548
	xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736]	Divided	215.028	206.623	1.04068
857	midasin (midas-containing protein). [swissprot;acc:q9nu22]	Subtracted	237.218	228.698	8.52
	putatative 28 kda protein. [refseq;acc:nm_020143]	Divided	227.241	236.467	1.0406
858	signal recognition particle 68 kda protein (srp68). [swissprot;acc:q9uhb9]	Subtracted	221.306	212.806	8.5
	syntaxin 12. [refseq;acc:nm_177424]	Divided	217.446	208.997	1.04043
859	60s ribosomal protein l39. [swissprot;acc:p02404]		234.025	224.958	1.04031
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Subtracted	50.7983	42.3003	8.498
860	60s ribosomal protein l18a. [swissprot;acc:q02543]	Divided	234.025	224.958	1.04031
	nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917]	Subtracted	242.024	233.544	8.48
861	40s ribosomal protein s19. [swissprot;acc:p39019]	Divided	234.025	224.958	1.04031
	syntaxin 12. [refseq;acc:nm_177424]	Subtracted	217.446	208.997	8.449
862	60s ribosomal protein l31. [swissprot;acc:p12947]	Divided	234.025	224.958	1.04031
	pyruvate kinase, m1 isozyme (ec 2.7.1.40) (pyruvate kinase muscle isozyme) (cytosolic thyroid hormone-binding protein) (cthbp) (thbp1). [swissprot;acc:p14618]	Subtracted	231.357	239.778	8.421
863	casein kinase ii, alpha chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19138]	Divided	240.194	230.957	1.03999
	xenotropic and polytropic retrovirus receptor. [refseq;acc:nm_004736]	Subtracted	215.028	206.623	8.405

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.