MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 1 to 50 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	18	GBE1	High confidence	185.678	245.247	1.32082
	4130		Low confidence	199.383	201.5	1.01062
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	1038	no value	High confidence	186.741	181.041	1.03148
	1328		Low confidence	198.342	194.038	1.02218
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	1032	AGPAT2	High confidence	186.664	180.943	1.03162
	1322		Low confidence	198.322	194.014	1.0222
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	588	AGPAT4		191.507	185.859	1.03039
	1048		High confidence	187.96	182.308	1.031
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	637	AGPAT3	Low confidence	192.166	186.751	1.029
	1043		High confidence	187.834	182.137	1.03128
1-aminocyclopropane-1-carboxylate synthase. [refseq;acc:nm_032592]	3423	no value	Low confidence	199.702	196.707	1.01523
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	3126	PLCB4	High confidence	0.00001	0.00001	1
	3585		Low confidence	202.517	199.628	1.01447
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	1963	HSPE1	High confidence	211.633	213.703	1.00978
	2659		Low confidence	200.053	196.574	1.0177
10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]	1873	ALDH1L1		203.414	199.455	1.01985
	2922		High confidence	0.00001	0.00001	1
130 kda leucine-rich protein (lrp 130) (gp130) (leucine-rich ppr-motif containing protein). [swissprot;acc:p42704]	4255	LRPPRC	Low confidence	202.306	200.395	1.00954
14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946]	2076	YWHAB		198.587	194.83	1.01928
	2439		High confidence	220.681	221.425	1.00337
14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655]	2864	YWHAE	Low confidence	200.418	197.043	1.01713
	3088		High confidence	0.00001	0.00001	1
14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312]	2108	YWHAZ	Low confidence	198.65	194.902	1.01923
	2396		High confidence	220.683	221.51	1.00375
14.5 kda translational inhibitor protein (p14.5) (uk114 antigen homolog). [swissprot;acc:p52758]	1044	HRSP12	Low confidence	201.723	196.966	1.02415
	2366		High confidence	203.353	202.529	1.00407
15 kda selenoprotein precursor. [swissprot;acc:o60613]	1948	no value		214.522	212.432	1.00984
	4465		Low confidence	202.928	201.104	1.00907
15-hydroxyprostaglandin dehydrogenase [nad(+)] (ec 1.1.1.141) (pgdh). [swissprot;acc:p15428]	2855	HPGD	High confidence	0.00001	0.00001	1
	4126		Low confidence	197.858	195.778	1.01062
16.7kd protein. [refseq;acc:nm_016139]	3267	CHCHD2		198.949	195.864	1.01575
17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]	1051	no value	High confidence	211.449	217.998	1.03097
	1803		Low confidence	199.592	195.655	1.02012
17-beta-hydroxysteroid dehydrogenase type vii-like. [refseq;acc:nm_182829]	2142	HSD17B7P2		196.577	192.884	1.01915
2,4-dienoyl coa reductase 2, peroxisomal; peroxisomal 2,4-dienoyl-coa reductase. [refseq;acc:nm_020664]	3846	DECR2		201.014	198.422	1.01306
2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor (ec 2.4.1.45) (udp-galactose-ceramide galactosyltransferase) (ceramide udp-galactosyltransferase) (cerebroside synthase). [swissprot;acc:q16880]	4455	UGT8		207	205.097	1.00928
2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83]	941	HACL1		207.026	201.99	1.02493
	2007		High confidence	225.019	222.969	1.00919
2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	994	OGDH	Low confidence	201.562	196.729	1.02457
	1160		High confidence	208.55	214.041	1.02633
2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [swissprot;acc:p12694]	1484	TMEM91		198.927	202.726	1.0191
	4541		Low confidence	202.824	201.202	1.00806
2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdh e1-beta). [swissprot;acc:p21953]	1389	BCKDHB	High confidence	218.47	213.875	1.02148
	1439		Low confidence	203.206	198.891	1.0217
20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	183	NCBP2	High confidence	228.306	198.011	1.153
	276		Low confidence	199.939	191.474	1.04421
25 kda brain-specific protein (p25-alpha). [swissprot;acc:o94811]	1085	TPPP		203.933	199.188	1.02382
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	25	CYP27B1		286.396	238.476	1.20094
	3079		High confidence	0.00001	0.00001	1
26s protease regulatory subunit 4 (p26s4). [swissprot;acc:q03527]	2503	PSMC1		215.581	216.137	1.00258

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.