MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Value Type	Filtered	Rank	Gene	description	green	Interaction Map	network_comparison	Network Comparison Type	red

Results: HTML CSV LaTeX

Showing element 3682 to 3731 of 19268 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	green	Interaction Map	network_comparison	Network Comparison Type	red
248	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	155.476	Low confidence	1.04682	Divided	162.755
249	dual oxidase 1 precursor; nadph thyroid oxidase 1; flavoprotein nadph oxidase; nicotinamide adenine dinucleotide phosphate oxidase. [refseq;acc:nm_017434]	201.076		1.0468		210.487
	ns1-associated protein 1. [refseq;acc:nm_006372]	212.41	High confidence	1.11719		237.302
	small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	202.333		23.776	Subtracted	226.109
	transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653]	210.503	Low confidence	9.246		219.749
250	alpha-amylase, salivary precursor (ec 3.2.1.1) (1,4-alpha-d-glucan glucanohydrolase). [swissprot;acc:p04745]	210.498		9.244		219.742
	diacylglycerol o-acyltransferase 1 (ec 2.3.1.20) (diglyceride acyltransferase) (acat related gene product 1). [swissprot;acc:o75907]	201.051		1.04671	Divided	210.443
	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	212.41	High confidence	1.11719		237.302
	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]	186.95		23.743	Subtracted	210.693
251	40s ribosomal protein s20. [swissprot;acc:p17075]	267.21		23.71		243.5
	nadph oxidase, ef hand calcium-binding domain 5. [refseq;acc:nm_024505]	201.035	Low confidence	1.04666	Divided	210.415
	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]	166.661	High confidence	1.11707		186.172
	upstream binding protein 1 (lbp-1a). [refseq;acc:nm_014517]	210.484	Low confidence	9.238	Subtracted	219.722
252	cytochrome b-245 heavy chain (p22 phagocyte b-cytochrome) (neutrophil cytochrome b, 91 kda polypeptide) (cgd91-phox) (gp91-phox) (heme binding membrane glycoprotein gp91phox) (cytochrome b(558) beta chain) (superoxide-generating nadph oxidase heavy chain subunit). [swissprot;acc:p04839]	201.035		1.04665	Divided	210.414
	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	212.457	High confidence	1.11689		237.292
	mad protein (max dimerizer). [swissprot;acc:q05195]	204.333		23.667	Subtracted	228
	u2 small nuclear ribonucleoprotein b". [swissprot;acc:p08579]	193.53	Low confidence	9.124		202.654
253	mad protein (max dimerizer). [swissprot;acc:q05195]	204.333	High confidence	1.11583	Divided	228
	nadph oxidase 4. [refseq;acc:nm_016931]	201.035	Low confidence	1.04665		210.413
	nuclear transcription factor y subunit beta (nf-y protein chain b) (nf-yb) (ccaat-binding transcription factor subunit a) (cbf-a) (caat- box dna binding protein subunit b). [swissprot;acc:p25208]	228.037	High confidence	23.642	Subtracted	251.679
	parafibromin. [refseq;acc:nm_024529]	204.916	Low confidence	9.099		214.015
254	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	204.357	High confidence	23.642		227.999
	nadph oxidase 3; nadph oxidase catalytic subunit-like 3. [refseq;acc:nm_015718]	201.035	Low confidence	1.04665	Divided	210.414
	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]	209.763		9.022	Subtracted	218.785
	source of immunodominant mhc-associated peptides; homolog of yeast stt3 gene. [refseq;acc:nm_178862]	179.88	High confidence	1.11569	Divided	200.691
255	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]	204.366		23.633	Subtracted	227.999
	nadph oxidase homolog 1 (nox-1) (noh-1) (nadh/nadph mitogenic oxidase subunit p65-mox) (mitogenic oxidase 1) (mox1). [swissprot;acc:q9y5s8]	201.035	Low confidence	1.04665	Divided	210.413
	nucleotide binding protein 2 (nbp 2). [swissprot;acc:q9y5y2]	191.678		9.021	Subtracted	200.699
	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	179.88	High confidence	1.11569	Divided	200.691
256	max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]	204.37		23.629	Subtracted	227.999
	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	204.357		1.11569	Divided
	oligosaccharyl transferase stt3 subunit homolog (b5) (integral membrane protein 1) (tmc). [swissprot;acc:p46977]	190.521	Low confidence	1.04648		199.376
	sterol o-acyltransferase 2 (ec 2.3.1.26) (cholesterol acyltransferase 2) (acyl coenzyme a:cholesterol acyltransferase 2) (acat-2). [swissprot;acc:o75908]	199.455		9.014	Subtracted	208.469
257	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656]	179.88	High confidence	1.11569	Divided	200.691
	jagged 2 precursor (jagged2) (hj2). [swissprot;acc:q9y219]	209.71	Low confidence	9.005	Subtracted	218.715
	tropomyosin alpha 3 chain (tropomyosin 3) (tropomyosin gamma). [swissprot;acc:p06753]	192.404		1.04632	Divided	201.316
	ump-cmp kinase (ec 2.7.4.14) (cytidylate kinase) (deoxycytidylate kinase) (cytidine monophosphate kinase). [swissprot;acc:p30085]	265.697	High confidence	23.557	Subtracted	242.14
258	gtp:amp phosphotransferase mitochondrial (ec 2.7.4.10) (ak3) (adenylate kinase 3 alpha like 1). [swissprot;acc:q9uij7]
	jagged 1 precursor (jagged1) (hj1). [swissprot;acc:p78504]	209.709	Low confidence	9.005		218.714
	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]	204.366	High confidence	1.11564	Divided	227.999
	tropomyosin 1 alpha chain (alpha-tropomyosin). [swissprot;acc:p09493]	192.427	Low confidence	1.04613		201.304
259	adenylate kinase isoenzyme 4, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p27144]	265.696	High confidence	23.556	Subtracted	242.14
	max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]	204.37		1.11562	Divided	227.999
	myocyte-specific enhancer factor 2c. [swissprot;acc:q06413]	209.709	Low confidence	9.005	Subtracted	218.714
	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]	202.482		1.04599	Divided	211.794
260	ankyrin repeat domain protein 7 (testis-specific protein tsa806). [swissprot;acc:q92527]	207.34		1.04589		216.855
	c439a6.1 (novel protein similar to heparan sulfate (glucosamine) 3-o- sulfotransferases) (fragment). [sptrembl;acc:q96qi5]	196.978	High confidence	1.11394		219.421
	myocyte-specific enhancer factor 2a (serum response factor-like protein 1). [swissprot;acc:q02078]	209.71	Low confidence	9.005	Subtracted	218.715
	surfeit locus protein 5. [swissprot;acc:q15528]	265.696	High confidence	23.556		242.14
261	ba526d8.2 (novel protein similar to kiaa1074). [sptrembl;acc:q9h560]	207.333	Low confidence	1.04588	Divided	216.845

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.