MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Value Type	red	network_comparison	green
1	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	UBAC1	Ranked	10	2.4	24
	rad50-interacting protein 1. [refseq;acc:nm_021930]	RINT1	Measured	450.5	5.31521	2394.5
			Squared	48.0356	28.2513	1357.07
			Rooted	21.225	2.30547	48.9336
2	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	no value	Ranked	15	1.86667	28
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	RHOBTB2	Measured	450.5	5.31521	2394.5
			Squared	48.0356	28.2513	1357.07
			Rooted	21.225	2.30547	48.9336
3	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	PSCD1	Ranked	15	1.86667	28
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	HLX	Measured	2597.5	3.71868	698.5
			Squared	1596.92	13.8285	115.48
			Rooted	50.9657	1.92839	26.4292
4	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	PSCD2	Ranked	15	1.86667	28
	hbs1-like. [refseq;acc:nm_006620]	HBS1L	Measured	2597.5	3.71868	698.5
			Squared	1596.92	13.8285	115.48
			Rooted	50.9657	1.92839	26.4292
5	cytohesin 4. [swissprot;acc:q9uia0]	PSCD4	Ranked	15	1.86667	28
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	JPH3	Measured	1153.5	3.39764	339.5
			Squared	314.926	11.544	27.2805
			Rooted	33.9632	1.84327	18.4255
6	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	PSCD3	Ranked	15	1.86667	28
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	JPH2	Measured	1153.5	3.39764	339.5
			Squared	314.926	11.544	27.2805
			Rooted	33.9632	1.84327	18.4255
7	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	HLX	Ranked	215	1.49767	322
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	SMPD2	Measured	1153.5	3.39764	339.5
			Squared	314.926	11.544	27.2805
			Rooted	33.9632	1.84327	18.4255
8	db83 protein. [swissprot;acc:p57088]	TMEM33	Measured	1153.5	3.39764	339.5
			Squared	314.926	11.544	27.2805
			Rooted	33.9632	1.84327	18.4255
	hbs1-like. [refseq;acc:nm_006620]	HBS1L	Ranked	215	1.49767	322
9	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	TOB2	Measured	398.5	3.21581	1281.5
			Squared	37.5863	10.3414	388.696
			Rooted	19.9625	1.79326	35.798
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	XAB1	Ranked	212	1.45755	309
10	protein x 0004. [refseq;acc:nm_016301]	ATPBD1C
	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]	TOB1	Measured	398.5	3.21581	1281.5
			Squared	37.5863	10.3414	388.696
			Rooted	19.9625	1.79326	35.798
11	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	DAB2IP	Measured	398.5	3.21581	1281.5
			Squared	37.5863	10.3414	388.696
			Rooted	19.9625	1.79326	35.798
	rad50-interacting protein 1. [refseq;acc:nm_021930]	RINT1	Ranked	337	1.45259	232
12	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	CPEB4	Measured	398.5	3.21581	1281.5
			Squared	37.5863	10.3414	388.696
			Rooted	19.9625	1.79326	35.798
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	RHOBTB2	Ranked	337	1.45259	232
13	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	CPEB3	Measured	398.5	3.21581	1281.5
			Squared	37.5863	10.3414	388.696

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.