MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Network Comparison Type	Hugo	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Network Comparison Type	Hugo	Interaction Map	red	network_comparison	green
1	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Divided	CPD	Low confidence	16	2	32
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Subtracted	HLX	High confidence	215	107	322
	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]		LAMP1	Low confidence	223		330
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Divided	UBAC1	High confidence	10	2.4	24
2	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Subtracted	CDK4	Low confidence	223	107	330
	hbs1-like. [refseq;acc:nm_006620]		HBS1L	High confidence	215		322
	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Divided	LAMP1	Low confidence	223	1.47982	330
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]		no value	High confidence	15	1.86667	28
3	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]		CDK4	Low confidence	223	1.47982	330
	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Subtracted	CDK6			107
	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Divided	PSCD1	High confidence	15	1.86667	28
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Subtracted	RINT1		337	105	232
4	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Divided	CDK6	Low confidence	223	1.47982	330
	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]		PSCD2	High confidence	15	1.86667	28
	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Subtracted	LAMP2	Low confidence	223	107	330
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]		RHOBTB2	High confidence	337	105	232
5	cytohesin 4. [swissprot;acc:q9uia0]	Divided	PSCD4		15	1.86667	28
	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]		LAMP2	Low confidence	223	1.47982	330
	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Subtracted	OSBPL6		318	78	240
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]		XAB1	High confidence	212	97	309
6	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Divided	PSCD3		15	1.86667	28
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	Subtracted	OSBPL3	Low confidence	318	78	240
	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Divided	OSBPL6			1.325
	protein x 0004. [refseq;acc:nm_016301]	Subtracted	ATPBD1C	High confidence	212	97	309
7	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Divided	HLX		215	1.49767	322
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]		OSBPL3	Low confidence	318	1.325	240
	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	Subtracted	OSBPL7			78
	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]		UFC1	High confidence	288.754	76.2	212.554
8	hbs1-like. [refseq;acc:nm_006620]	Divided	HBS1L		215	1.49767	322
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Subtracted	JPH3		288	74	362
	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	Divided	OSBPL7	Low confidence	318	1.325	240
	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	Subtracted	JMJD1C		305.472	58.226	247.246
9	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Divided	MRPS17		58	1.31818	44
	gbp protein isoform a. [refseq;acc:nm_017870]	Subtracted	TMEM132A		305.399	58.186	247.213
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]		JPH2	High confidence	288	74	362
	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Divided	XAB1		212	1.45755	309
10	jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]	Subtracted	JMJD1A	Low confidence	305.303	58.134	247.169
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Divided	SLC25A43		58	1.31818	44
	protein x 0004. [refseq;acc:nm_016301]		ATPBD1C	High confidence	212	1.45755	309
	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	Subtracted	SMPD2		288	74	362
11	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]	Divided	BEST1	Low confidence	37.318	1.30966	28.4944
	db83 protein. [swissprot;acc:p57088]	Subtracted	TMEM33	High confidence	288	74	362
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Divided	RINT1		337	1.45259	232
	trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]	Subtracted	PRSS3	Low confidence	304.548	57.724	246.824
12	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]		no value	High confidence	266.856	69.377	336.233
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Divided	RHOBTB2		337	1.45259	232
	trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]	Subtracted	PRSS1	Low confidence	304.359	57.622	246.737
	vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]	Divided	BEST4		37.3475	1.30933	28.5242
13	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	Subtracted	GNG12	High confidence	266.856	69.377	336.233
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Divided	no value	Low confidence	37.9984	1.30207	29.1831

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.