MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Network Comparison Type	Rank	Hugo	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 1 to 50 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Hugo	Value Type	red	green	network_comparison
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Divided	18	GBE1	Ranked	185.678	245.247	1.32082
		60		Measured	4489.19	2765.82	1.6231
		64		Rooted	63.8686	47.2654	1.35128
		245		Squared	8875.01	6768.05	1.31131
	Subtracted	54		Ranked	185.678	245.247	59.569
		67		Rooted	63.8686	47.2654	16.6032
		164		Measured	4489.19	2765.82	1723.37
		1962		Squared	8875.01	6768.05	2106.96
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	Divided	295	no value		30807.7	39351.7	1.27733
		509		Measured	7551.8	8630.06	1.14278
		805		Rooted	74.3557	79.1513	1.0645
		1038		Ranked	186.741	181.041	1.03148
	Subtracted	274		Squared	30807.7	39351.7	8544
		310		Measured	7551.8	8630.06	1078.26
		610		Rooted	74.3557	79.1513	4.7956
		1120		Ranked	186.741	181.041	5.7
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	Divided	294	AGPAT2	Squared	30826.5	39383.9	1.2776
		508		Measured	7556.75	8636.87	1.14293
		804		Rooted	74.3877	79.1931	1.0646
		1032		Ranked	186.664	180.943	1.03162
	Subtracted	273		Squared	30826.5	39383.9	8557.4
		307		Measured	7556.75	8636.87	1080.12
		609		Rooted	74.3877	79.1931	4.8054
		1115		Ranked	186.664	180.943	5.721
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	Divided	311	AGPAT4	Squared	30566.4	38866.5	1.27154
		514		Measured	7477	8532.02	1.1411
		822		Rooted	73.8577	78.5795	1.06393
		1048		Ranked	187.96	182.308	1.031
	Subtracted	280		Squared	30566.4	38866.5	8300.1
		319		Measured	7477	8532.02	1055.02
		631		Rooted	73.8577	78.5795	4.7218
		1128		Ranked	187.96	182.308	5.652
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	Divided	308	AGPAT3	Squared	30596.2	38919.9	1.27205
		513		Measured	7485.08	8543.66	1.14143
		811		Rooted	73.9102	78.6514	1.06415
		1043		Ranked	187.834	182.137	1.03128
	Subtracted	279		Squared	30596.2	38919.9	8323.7
		318		Measured	7485.08	8543.66	1058.58
		616		Rooted	73.9102	78.6514	4.7412
		1121		Ranked	187.834	182.137	5.697
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	Divided	3126	PLCB4	Measured	0.00001	0.00001	1
				Ranked
				Squared
				Rooted
	Subtracted			Measured	0	0	0
				Ranked
				Squared
				Rooted
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	Divided	588	HSPE1	Squared	23526.4	27879.3	1.18502
		1136		Measured	5790.65	6303.92	1.08864

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.