MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	description	Network Comparison Type	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 66312 in total

Filtered  : 1

Rank	Hugo	Value Type	description	Network Comparison Type	Interaction Map	network_comparison	red	green
1	no value	Measured	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Subtracted	High confidence	8126	41482.5	33356.5
	CPD		carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]		Low confidence	8870.5	40899	32028.5
		Ranked		Divided		2	16	32
		Squared		Subtracted		153113	395912	242799
	HLX	Ranked	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]		High confidence	107	215	322
	LAMP1	Measured	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Divided	Low confidence	4.4149	2399.5	543.5
		Ranked		Subtracted		107	223	330
		Squared		Divided		19.4914	1362.75	69.9153
		Rooted				2.10117	48.9847	23.3131
				Subtracted		25.6716
	RINT1	Measured	rad50-interacting protein 1. [refseq;acc:nm_021930]	Divided	High confidence	5.31521	450.5	2394.5
		Squared				28.2513	48.0356	1357.07
		Rooted				2.30547	21.225	48.9336
				Subtracted		27.7086
	UBAC1	Ranked	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Divided		2.4	10	24
		Squared		Subtracted		145743	468498	322755
2	no value	Ranked	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Divided		1.86667	15	28
		Squared		Subtracted		143938	407289	263351
	BEST1		bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]		Low confidence	141563	333556	475119
	CDK4	Measured	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Divided		4.4149	2399.5	543.5
		Ranked		Subtracted		107	223	330
		Squared		Divided		19.4914	1362.75	69.9153
		Rooted				2.10117	48.9847	23.3131
				Subtracted		25.6716
	HBS1L	Ranked	hbs1-like. [refseq;acc:nm_006620]		High confidence	107	215	322
	LAMP1		lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Divided	Low confidence	1.47982	223	330
	MRPS17	Measured	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Subtracted		7307	21185	28492
	PSCD1		cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]		High confidence	8126	41482.5	33356.5
	RHOBTB2		rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Divided		5.31521	450.5	2394.5
		Squared				28.2513	48.0356	1357.07
		Rooted				2.30547	21.225	48.9336
				Subtracted		27.7086
3	BEST4	Squared	vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]		Low confidence	141539	333506	475045
	CDK4	Ranked	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Divided		1.47982	223	330
	CDK6	Measured	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]			4.4149	2399.5	543.5
		Ranked		Subtracted		107	223	330
		Squared		Divided		19.4914	1362.75	69.9153
		Rooted				2.10117	48.9847	23.3131
				Subtracted		25.6716
	HLX	Measured	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Divided	High confidence	3.71868	2597.5	698.5
		Squared				13.8285	1596.92	115.48
		Rooted				1.92839	50.9657	26.4292
				Subtracted		24.5365
	PSCD1	Ranked	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Divided		1.86667	15	28
		Squared		Subtracted		143938	407289	263351
	PSCD2	Measured	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]			8126	41482.5	33356.5
	RINT1	Ranked	rad50-interacting protein 1. [refseq;acc:nm_021930]			105	337	232
	SLC25A43	Measured	mitochondrial solute carrier protein. [refseq;acc:nm_145305]		Low confidence	7307	21185	28492
4	no value	Squared	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]			140997	332411	473408
	BEST1	Measured	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]			7035.1	36474.3	43509.4

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.