MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Network Comparison Type	Rank	Gene	description	Value Type	Hugo	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 66312 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Value Type	Hugo	Interaction Map	network_comparison	red	green
1	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Ranked	CPD	Low confidence	2	16	32
	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Measured	LAMP1		4.4149	2399.5	543.5
		Squared			19.4914	1362.75	69.9153
		Rooted			2.10117	48.9847	23.3131
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Ranked	UBAC1	High confidence	2.4	10	24
	rad50-interacting protein 1. [refseq;acc:nm_021930]	Measured	RINT1		5.31521	450.5	2394.5
		Squared			28.2513	48.0356	1357.07
		Rooted			2.30547	21.225	48.9336
2	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Measured	CDK4	Low confidence	4.4149	2399.5	543.5
		Squared			19.4914	1362.75	69.9153
		Rooted			2.10117	48.9847	23.3131
	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Ranked	LAMP1		1.47982	223	330
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]		no value	High confidence	1.86667	15	28
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Measured	RHOBTB2		5.31521	450.5	2394.5
		Squared			28.2513	48.0356	1357.07
		Rooted			2.30547	21.225	48.9336
3	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Ranked	CDK4	Low confidence	1.47982	223	330
	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Measured	CDK6		4.4149	2399.5	543.5
		Squared			19.4914	1362.75	69.9153
		Rooted			2.10117	48.9847	23.3131
	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Ranked	PSCD1	High confidence	1.86667	15	28
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Measured	HLX		3.71868	2597.5	698.5
		Squared			13.8285	1596.92	115.48
		Rooted			1.92839	50.9657	26.4292
4	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Ranked	CDK6	Low confidence	1.47982	223	330
	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]		PSCD2	High confidence	1.86667	15	28
	hbs1-like. [refseq;acc:nm_006620]	Measured	HBS1L		3.71868	2597.5	698.5
		Squared			13.8285	1596.92	115.48
		Rooted			1.92839	50.9657	26.4292
	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Measured	LAMP2	Low confidence	4.4149	2399.5	543.5
		Squared			19.4914	1362.75	69.9153
		Rooted			2.10117	48.9847	23.3131
5	cytohesin 4. [swissprot;acc:q9uia0]	Ranked	PSCD4	High confidence	1.86667	15	28
	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Measured	JPH3		3.39764	1153.5	339.5
		Squared			11.544	314.926	27.2805
		Rooted			1.84327	33.9632	18.4255
	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Ranked	LAMP2	Low confidence	1.47982	223	330
	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Measured	OSBPL6		2.86965	736.5	2113.5
		Squared			8.23493	128.386	1057.25
		Rooted			1.69401	27.1385	45.9728
6	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Ranked	PSCD3	High confidence	1.86667	15	28
	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Measured	JPH2		3.39764	1153.5	339.5
		Squared			11.544	314.926	27.2805
		Rooted			1.84327	33.9632	18.4255
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	Measured	OSBPL3	Low confidence	2.86965	736.5	2113.5
		Squared			8.23493	128.386	1057.25
		Rooted			1.69401	27.1385	45.9728
	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Ranked	OSBPL6		1.325	318	240
7	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]		HLX	High confidence	1.49767	215	322
	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]		OSBPL3	Low confidence	1.325	318	240

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.