MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 568 to 617 of 9634 in total

Value Type  : Measured
Network Comparison Type  : Divided

description	Rank	Interaction Map	Filtered	red	green	network_comparison
adapter-related protein complex 3 mu 2 subunit (clathrin coat assembly protein ap47 homolog 2) (clathrin coat associated protein ap47 homolog 2) (golgi adaptor ap-1 47 kda protein homolog 2) (ha1 47 kda subunit homolog 2) (clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (p47b). [swissprot;acc:p53677]	3896	Low confidence	1	8131.89	8321.51	1.02332
adaptor protein with pleckstrin homology and src homology 2 domains. [refseq;acc:nm_020979]	2870	High confidence		0.00001	0.00001	1
	3865	Low confidence		8199.38	8392.72	1.02358
adaptor-associated kinase 1. [refseq;acc:nm_014911]	2219			8104.37	8358.61	1.03137
	2282	High confidence		5783.73	6048.91	1.04585
adaptor-related protein complex 1, mu 1 subunit (mu-adaptin 1) (adaptor protein complex ap-1 mu-1 subunit) (golgi adaptor ha1/ap1 adaptin mu-1 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 1) (clathrin coat assembly protein ap47) (clathrin coat associated protein ap47) (ap-mu chain family member mu1a). [swissprot;acc:q9bxs5]	1067	Low confidence		7794.59	8086.72	1.03748
	2007	High confidence		5684.61	6018.72	1.05877
adaptor-related protein complex 1, mu 2 subunit (mu-adaptin 2) (adaptor protein complex ap-1 mu-2 subunit) (golgi adaptor ha1/ap1 adaptin mu-2 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 2) (ap-mu chain family member mu1b). [swissprot;acc:q9y6q5]	295		0	426.8	384.843	1.10902
	626	Low confidence		5201.75	5361.78	1.03076
	1063		1	7793.78	8086.18	1.03752
	2010	High confidence		5671.62	6003.67	1.05855
adenine phosphoribosyltransferase (ec 2.4.2.7) (aprt). [swissprot;acc:p07741]	374		0	2323.8	2452.23	1.05527
	579	Low confidence		1842.51	1922.24	1.04327
	2104		1	8183.03	8442.79	1.03174
	2519	High confidence		5964.17	6113.96	1.02511
adenomatous polyposis coli like. [refseq;acc:nm_005883]	174	Low confidence	0	2544.19	3114.19	1.22404
	4706		1	6234.4	6148.55	1.01396
adenomatous polyposis coli protein (apc protein). [swissprot;acc:p25054]	4710			6233.66	6148.69	1.01382
adenosine deaminase (ec 3.5.4.4) (adenosine aminohydrolase). [swissprot;acc:p00813]	146		0	1073.89	835.57	1.28522
	1358		1	8000.32	8280.09	1.03497
adenosine kinase (ec 2.7.1.20) (ak) (adenosine 5'-phosphotransferase). [swissprot;acc:p55263]	1581	High confidence		6376.12	6833.59	1.07175
	2072	Low confidence		8133.86	8392.72	1.03182
adenosylhomocysteinase (ec 3.3.1.1) (s-adenosyl-l-homocysteine hydrolase) (adohcyase). [swissprot;acc:p23526]	940	High confidence		5568.96	6113.35	1.09775
	3058	Low confidence		8048.72	8272.77	1.02784
adenovirus 5 e1a-binding protein (bs69 protein). [swissprot;acc:q15326]	1851	High confidence		6156.28	6549.03	1.0638
	2776	Low confidence		8010.75	8244.63	1.0292
adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [swissprot;acc:o95622]	401	High confidence		5201.41	4479.76	1.16109
	3159	Low confidence		7975.92	8194.54	1.02741
adenylate cyclase, type vi (ec 4.6.1.1) (atp pyrophosphate-lyase) (ca(2+)-inhibitable adenylyl cyclase). [swissprot;acc:o43306]	400	High confidence		5201.41	4479.76	1.16109
	3158	Low confidence		7975.92	8194.54	1.02741
adenylate kinase isoenzyme 2, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p54819]	2385	High confidence		3716.43	3569.68	1.04111
	4422	Low confidence		8168.38	8329	1.01966
adenylate kinase isoenzyme 4, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p27144]	347	High confidence	0	1491.75	1591.6	1.06693
	484	Low confidence		1344.45	1431.5	1.06475
	2228	High confidence	1	3650.82	3484.97	1.04759
	4696	Low confidence		7409.04	7516.41	1.01449
adenylosuccinate lyase (ec 4.3.2.2) (adenylosuccinase) (asl) (asase). [swissprot;acc:p30566]	1640	High confidence		7444.28	7964	1.06981
	1704	Low confidence		8171.93	8443.14	1.03319
adenylosuccinate synthase-like 1. [refseq;acc:nm_152328]	479	High confidence	0	1318.37	1310.67	1.00587
	505	Low confidence		2027.06	1913.73	1.05922
	548		1	8447.46	8841.77	1.04668
	679	High confidence		6503.1	7282.94	1.11992
adenylosuccinate synthetase (ec 6.3.4.4) (imp--aspartate ligase) (adss) (ampsase). [swissprot;acc:p30520]	546	Low confidence		8451.27	8845.91	1.0467
	680	High confidence		6503.03	7282.5	1.11986
adenylyl cyclase-associated protein 1 (cap 1). [swissprot;acc:q01518]	1541			5989.3	6427.17	1.07311
	2524	Low confidence		8100.8	8345.7	1.03023
adenylyl cyclase-associated protein 2 (cap 2). [swissprot;acc:p40123]	262	High confidence	0	764.479	676.971	1.12926
	707	Low confidence		2355.39	2316.06	1.01698
	1562	High confidence	1	5984.88	6419.11	1.07255
	2537	Low confidence		8104.44	8349.23	1.0302

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.