MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 516 in total

Value Type  : Ranked
Network Comparison Type  : Subtracted
Interaction Map  : High confidence
Filtered  : 1
red  : 0
green  : 0
network_comparison  : 0

Rank	description	Hugo
2756	3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8]	no value
2757	nucleosome assembly protein 1-like 1 (nap-1 related protein). [swissprot;acc:p55209]	NAP1L1
2758	nucleosome assembly protein 1-like 2 (brain-specific protein, x- linked). [swissprot;acc:q9ulw6]	NAP1L2
2759	retinoic acid receptor rxr-alpha. [swissprot;acc:p19793]	RXRA
2760	t-cell acute lymphocytic leukemia-2 protein (tal-2 protein). [swissprot;acc:q16559]	TAL2
2761	guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]	GNB1L
2762	developmentally regulated gtp-binding protein 1 (drg 1). [swissprot;acc:q9y295]	DRG1
2763	ring finger protein 3. [refseq;acc:nm_006315]	PCGF3
2764	ras-related protein rab-11b (gtp-binding protein ypt3). [swissprot;acc:q15907]	RAB11B
2765	histone h2a.e (h2a/e). [swissprot;acc:q99878]	no value
2766	ss18-like protein 1 (syt homolog-1). [swissprot;acc:o75177]	SS18L1
2767	histone h2a.c/d/i/n/p (h2a.1) (h2a/c) (h2a/d) (h2a/i) (h2a/n) (h2a/p) (h2a.1b). [swissprot;acc:p02261]	no value
2768	histone h2a.x (h2a/x). [swissprot;acc:p16104]	HIST2H2AB
2769	histone h2a.q (h2a/q) (h2a-gl101) (fragment). [swissprot;acc:q16777]	HIST2H2AC
2770	nipsnap1 protein. [swissprot;acc:q9bpw8]	NIPSNAP1
2771	t-box transcription factor tbx1 (t-box protein 1) (testis-specific t-box protein). [swissprot;acc:o43435]	TBX1
2772	uridine diphosphate glucose pyrophosphatase. [refseq;acc:nm_177533]	NUDT14
2773	bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [swissprot;acc:p34820]	BMP8A
2774	dc12 protein. [refseq;acc:nm_020187]	C3orf37
2775	jerky protein homolog like (hhmjg). [swissprot;acc:q9y4a0]	JRKL
2776	bcl-6 interacting corepressor isoform 1. [refseq;acc:nm_017745]	BCOR
2777	guanine nucleotide exchange factor mss4 (rab interacting factor). [swissprot;acc:p47224]	RABIF
2778	transcription factor mammalian mafa (pancreatic beta-cell specific transcriptional activator). [sptrembl;acc:q8nhw3]	MAFA
2779	caveolin-3 (m-caveolin). [swissprot;acc:p56539]	CAV3
2780	importin alpha-2 subunit (karyopherin alpha-2 subunit) (srp1-alpha) (rag cohort protein 1). [swissprot;acc:p52292]	KPNA2
2781	exocyst complex component exo70. [swissprot;acc:q9upt5]	EXOC7
2782	vacuolar atp synthase membrane sector associated protein m8-9 (v-atpase m8.9 subunit). [swissprot;acc:o75787]	ATP6AP2
2783	mab-21-like protein 2; mab-21-like 2. [refseq;acc:nm_006439]	MAB21L2
2784	histone h2a.a (h2a/a) (h2a.2). [swissprot;acc:p28001]	HIST3H2A
2785	nucleophosmin (npm) (nucleolar phosphoprotein b23) (numatrin) (nucleolar protein no38). [swissprot;acc:p06748]	NPM1
2786	mab-21-like protein 1; mab-21-like 1. [refseq;acc:nm_005584]	MAB21L1
2787	high mobility group protein 4-like (hmg-4l). [swissprot;acc:q9uj13]	HMG4L
2788	a-kinase anchor protein 5 (a-kinase anchor protein 79 kda) (akap 79) (camp-dependent protein kinase regulatory subunit ii high affinity binding protein) (h21). [swissprot;acc:p24588]	AKAP5
2789	protein-tyrosine phosphatase, non-receptor type 11 (ec 3.1.3.48) (protein-tyrosine phosphatase 2c) (ptp-2c) (ptp-1d) (sh-ptp3) (sh- ptp2) (shp-2). [swissprot;acc:q06124]	PTPN11
2790	transcription factor mafb (v-maf musculoaponeurotic fibrosarcoma oncogene homolog b). [swissprot;acc:q9y5q3]	no value
2791	cytochrome c oxidase polypeptide va, mitochondrial precursor (ec 1.9.3.1). [swissprot;acc:p20674]	COX5A
2792	transcription factor maf (proto-oncogene c-maf). [swissprot;acc:o75444]	MAF
2793	udp-glucuronosyltransferase 2b17 precursor, microsomal (ec 2.4.1.17) (udpgt) (c19-steroid specific udp-glucuronosyltransferase). [swissprot;acc:o75795]	no value
2794	sh2-b homolog; likely ortholog of mouse sh2 domain-containing putative adapter sh2-b; sh2-b gamma signaling protein; sh2-b alpha signaling protein. [refseq;acc:nm_015503]	SH2B1
2795	nadh-ubiquinone oxidoreductase 24 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3). [swissprot;acc:p19404]	NDUFV2
2796	dna methyltransferase 1-associated protein 1 (dnmt1-associated protein 1) (dnmap1). [swissprot;acc:q9npf5]	DMAP1
2797	sperm tail protein shippo1; h-shippo 1. [refseq;acc:nm_053280]	ODF3
2798	ariadne-2 protein homolog (ari-2) (triad1 protein) (ht005). [swissprot;acc:o95376]	ARIH2
2799	hmg2 like. [refseq;acc:nm_145205]	HMGB4
2800	mondoa. [refseq;acc:nm_014938]	MLXIP
2801	dna-repair protein complementing xp-f cell (xeroderma pigmentosum group f complementing protein) (dna excision repair protein ercc-4). [swissprot;acc:q92889]	ERCC4
2802	3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type i (3beta-hsd i) (trophoblast antigen fdo161g) [includes: 3-beta-hydroxy- delta(5)-steroid dehydrogenase (ec 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (progesterone reductase); steroid delta- isomerase (ec 5.3.3.1) (delta-5-3-ketosteroid isomerase)]. [swissprot;acc:p14060]	no value
2803	nanos (fragment). [sptrembl;acc:q8wy41]
2804	barrier-to-autointegration factor (breakpoint cluster region protein 1). [swissprot;acc:o75531]	BANF1
2805	phosphofurin acidic cluster sorting protein 1 isoform 1; cytosolic sorting protein pacs-1. [refseq;acc:nm_018026]	PACS1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.