MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 1 to 7 of 7 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1
network_comparison  : 1.0194

Rank	Hugo	description	Interaction Map	red	green
1470	QARS	glutaminyl-trna synthetase (ec 6.1.1.18) (glutamine--trna ligase) (glnrs). [swissprot;acc:p47897]	High confidence	221.412	217.199
1471	SRM	spermidine synthase (ec 2.5.1.16) (putrescine aminopropyltransferase) (spdsy). [swissprot;acc:p19623]
1472	GARS	glycyl-trna synthetase (ec 6.1.1.14) (glycine--trna ligase) (glyrs). [swissprot;acc:p41250]
1473	EARS2	glutamyl trna synthetase. [sptrembl;acc:o14563]
2032	CNNM3	cyclin m3; ancient conserved domain protein 3. [refseq;acc:nm_017623]	Low confidence	199.274	195.481
2033	HSD11B1	corticosteroid 11-beta-dehydrogenase, isozyme 1 (ec 1.1.1.146) (11-dh) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-hsd1). [swissprot;acc:p28845]		202.411	206.338
2034	ALDH5A1	succinate semialdehyde dehydrogenase, mitochondrial precursor (ec 1.2.1.24) (nad(+)-dependent succinic semialdehyde dehydrogenase). [swissprot;acc:p51649]		205.018	201.117

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.