MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Value Type	Interaction Map	red	network_comparison	green
1	CPD	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Ranked	Low confidence	16	2	32
	LAMP1	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Measured		2399.5	4.4149	543.5
			Squared		1362.75	19.4914	69.9153
			Rooted		48.9847	2.10117	23.3131
	RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]	Measured	High confidence	450.5	5.31521	2394.5
			Squared		48.0356	28.2513	1357.07
			Rooted		21.225	2.30547	48.9336
	UBAC1	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Ranked		10	2.4	24
2	no value	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]			15	1.86667	28
	CDK4	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Measured	Low confidence	2399.5	4.4149	543.5
			Squared		1362.75	19.4914	69.9153
			Rooted		48.9847	2.10117	23.3131
	LAMP1	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Ranked		223	1.47982	330
	RHOBTB2	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Measured	High confidence	450.5	5.31521	2394.5
			Squared		48.0356	28.2513	1357.07
			Rooted		21.225	2.30547	48.9336
3	CDK4	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Ranked	Low confidence	223	1.47982	330
	CDK6	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Measured		2399.5	4.4149	543.5
			Squared		1362.75	19.4914	69.9153
			Rooted		48.9847	2.10117	23.3131
	HLX	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Measured	High confidence	2597.5	3.71868	698.5
			Squared		1596.92	13.8285	115.48
			Rooted		50.9657	1.92839	26.4292
	PSCD1	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Ranked		15	1.86667	28
4	CDK6	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]		Low confidence	223	1.47982	330
	HBS1L	hbs1-like. [refseq;acc:nm_006620]	Measured	High confidence	2597.5	3.71868	698.5
			Squared		1596.92	13.8285	115.48
			Rooted		50.9657	1.92839	26.4292
	LAMP2	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Measured	Low confidence	2399.5	4.4149	543.5
			Squared		1362.75	19.4914	69.9153
			Rooted		48.9847	2.10117	23.3131
	PSCD2	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Ranked	High confidence	15	1.86667	28
5	JPH3	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Measured		1153.5	3.39764	339.5
			Squared		314.926	11.544	27.2805
			Rooted		33.9632	1.84327	18.4255
	LAMP2	lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473]	Ranked	Low confidence	223	1.47982	330
	OSBPL6	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Measured		736.5	2.86965	2113.5
			Squared		128.386	8.23493	1057.25
			Rooted		27.1385	1.69401	45.9728
	PSCD4	cytohesin 4. [swissprot;acc:q9uia0]	Ranked	High confidence	15	1.86667	28
6	JPH2	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Measured		1153.5	3.39764	339.5
			Squared		314.926	11.544	27.2805
			Rooted		33.9632	1.84327	18.4255
	OSBPL3	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]	Measured	Low confidence	736.5	2.86965	2113.5
			Squared		128.386	8.23493	1057.25
			Rooted		27.1385	1.69401	45.9728
	OSBPL6	oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3]	Ranked		318	1.325	240
	PSCD3	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]		High confidence	15	1.86667	28
7	HLX	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]			215	1.49767	322
	OSBPL3	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]		Low confidence	318	1.325	240

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.