MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 642 in total

Hugo  : no value
Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
2	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Divided	15	28	1.86667
12	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	Subtracted	266.856	336.233	69.377
19	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		266.865	336.178	69.313
26	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]		322	253	69
30	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	Divided	187.457	243.678	1.29991
41	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]		322	253	1.27273
43	jun dimerization protein. [refseq;acc:nm_130469]		204.641	160.957	1.2714
56	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]		266.856	336.233	1.25998
63	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		266.865	336.178	1.25973
65	serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	Subtracted	187.457	243.678	56.221
85	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Divided	88.2482	110.265	1.24949
88	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]
94	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]
99	jun dimerization protein. [refseq;acc:nm_130469]	Subtracted	204.641	160.957	43.684
	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Divided	88.2482	110.265	1.24949
133	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Subtracted	226.887	194.72	32.167
134	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]		226.884	194.79	32.094
147	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Divided	50.7983	42.3003	1.2009
149	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]		142	170	1.19718
152	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]		55	46	1.19565
153	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	Subtracted	226.582	198.444	28.138
162	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]		142	170	28
168	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	Divided	82.5916	98.0548	1.18722
178	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]		226.887	194.72	1.1652
179	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]		226.884	194.79	1.16476
182	rd protein. [swissprot;acc:p18615]	Subtracted	227.357	254.15	26.793
191	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]		241.373	267.352	25.979
	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	Divided	226.582	198.444	1.14179
196	hpaii tiny fragments locus 9c. [refseq;acc:nm_022727]	Subtracted	272.781	246.892	25.889
198	40s ribosomal protein s29. [swissprot;acc:p30054]		241.849	267.642	25.793
200	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]		241.808	267.335	25.527
203	40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750]		240.758	266.078	25.32
208	60s ribosomal protein l23 (l17). [swissprot;acc:p23131]		240.782	265.717	24.935
210	rna-binding protein. [refseq;acc:nm_019027]		237.302	212.41	24.892
211	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]
215	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	Divided	112	126	1.125
219	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	Subtracted	242.339	266.986	24.647
221	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	Divided	112	126	1.125
222	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	Subtracted	242.153	266.673	24.52
233	60s ribosomal protein l7. [swissprot;acc:p18124]		235.727	259.984	24.257
238	rd protein. [swissprot;acc:p18615]	Divided	227.357	254.15	1.11785
242	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	Subtracted	241.892	265.959	24.067
243	60s ribosomal protein l23a. [swissprot;acc:p29316]		241.884	265.945	24.061
246	60s ribosomal protein l12 like protein. [sptrembl;acc:o60886]		243.583	267.528	23.945
247	60s ribosomal protein l12. [swissprot;acc:p30050]			267.527	23.944
	rna-binding protein. [refseq;acc:nm_019027]	Divided	237.302	212.41	1.11719
248	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]
	dj999l4.1 (novel protein similar to ribosomal protein l12 (rpl12)). [sptrembl;acc:q9nq02]	Subtracted	243.583	267.527	23.944
259	adenylate kinase isoenzyme 4, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p27144]		242.14	265.696	23.556
264	60s ribosomal protein l10a (csa-19). [swissprot;acc:p53025]		243.24	266.796

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.