MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	Hugo	Network Comparison Type	description	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	Network Comparison Type	description	Value Type	red	green	network_comparison
1	no value	Subtracted	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Measured	41482.5	33356.5	8126
	HLX		homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Ranked	215	322	107
	RINT1	Divided	rad50-interacting protein 1. [refseq;acc:nm_021930]	Measured	450.5	2394.5	5.31521
				Squared	48.0356	1357.07	28.2513
				Rooted	21.225	48.9336	2.30547
		Subtracted					27.7086
	UBAC1	Divided	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Ranked	10	24	2.4
		Subtracted		Squared	468498	322755	145743
2	no value	Divided	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Ranked	15	28	1.86667
		Subtracted		Squared	407289	263351	143938
	HBS1L		hbs1-like. [refseq;acc:nm_006620]	Ranked	215	322	107
	PSCD1		cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Measured	41482.5	33356.5	8126
	RHOBTB2	Divided	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]		450.5	2394.5	5.31521
				Squared	48.0356	1357.07	28.2513
				Rooted	21.225	48.9336	2.30547
		Subtracted					27.7086
3	HLX	Divided	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Measured	2597.5	698.5	3.71868
				Squared	1596.92	115.48	13.8285
				Rooted	50.9657	26.4292	1.92839
		Subtracted					24.5365
	PSCD1	Divided	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Ranked	15	28	1.86667
		Subtracted		Squared	407289	263351	143938
	PSCD2		cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Measured	41482.5	33356.5	8126
	RINT1		rad50-interacting protein 1. [refseq;acc:nm_021930]	Ranked	337	232	105
4	HBS1L	Divided	hbs1-like. [refseq;acc:nm_006620]	Measured	2597.5	698.5	3.71868
				Squared	1596.92	115.48	13.8285
				Rooted	50.9657	26.4292	1.92839
		Subtracted					24.5365
	PSCD2	Divided	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Ranked	15	28	1.86667
		Subtracted		Squared	407289	263351	143938
	PSCD4		cytohesin 4. [swissprot;acc:q9uia0]	Measured	41482.5	33356.5	8126
	RHOBTB2		rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Ranked	337	232	105
5	JPH3	Divided	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Measured	1153.5	339.5	3.39764
				Squared	314.926	27.2805	11.544
				Rooted	33.9632	18.4255	1.84327
	MRPS17	Subtracted	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]		145.551	168.796	23.245
	PSCD3		cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Measured	41482.5	33356.5	8126
	PSCD4	Divided	cytohesin 4. [swissprot;acc:q9uia0]	Ranked	15	28	1.86667
		Subtracted		Squared	407289	263351	143938
	XAB1		xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Ranked	212	309	97
6	ATPBD1C		protein x 0004. [refseq;acc:nm_016301]
	JPH2	Divided	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Measured	1153.5	339.5	3.39764
				Squared	314.926	27.2805	11.544
				Rooted	33.9632	18.4255	1.84327
	PANK1	Subtracted	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]		145.551	168.796	23.245
	PSCD3	Divided	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Ranked	15	28	1.86667
		Subtracted		Squared	407289	263351	143938
	UBAC1		putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Measured	44490.5	36927.5	7563
7	no value		nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	Squared	310840	442993	132153
	HLX	Divided	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Ranked	215	322	1.49767

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.