MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Gene	Rank	Value Type	Hugo	Network Comparison Type	description	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 1 to 50 of 66312 in total

Filtered  : 1

Rank	Value Type	Hugo	Network Comparison Type	description	Interaction Map	network_comparison	red	green
1	Measured	no value	Subtracted	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	High confidence	8126	41482.5	33356.5
		CPD		carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Low confidence	8870.5	40899	32028.5
		LAMP1	Divided	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]		4.4149	2399.5	543.5
		RINT1		rad50-interacting protein 1. [refseq;acc:nm_021930]	High confidence	5.31521	450.5	2394.5
	Ranked	CPD		carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Low confidence	2	16	32
		HLX	Subtracted	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	High confidence	107	215	322
		LAMP1		lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Low confidence		223	330
		UBAC1	Divided	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	High confidence	2.4	10	24
	Squared	CPD	Subtracted	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Low confidence	153113	395912	242799
		LAMP1	Divided	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]		19.4914	1362.75	69.9153
		RINT1		rad50-interacting protein 1. [refseq;acc:nm_021930]	High confidence	28.2513	48.0356	1357.07
		UBAC1	Subtracted	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]		145743	468498	322755
	Rooted	LAMP1	Divided	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Low confidence	2.10117	48.9847	23.3131
			Subtracted			25.6716
		RINT1	Divided	rad50-interacting protein 1. [refseq;acc:nm_021930]	High confidence	2.30547	21.225	48.9336
			Subtracted			27.7086
2	Measured	CDK4	Divided	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Low confidence	4.4149	2399.5	543.5
		MRPS17	Subtracted	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]		7307	21185	28492
		PSCD1		cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	High confidence	8126	41482.5	33356.5
		RHOBTB2	Divided	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]		5.31521	450.5	2394.5
	Ranked	no value		mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]		1.86667	15	28
		CDK4	Subtracted	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Low confidence	107	223	330
		HBS1L		hbs1-like. [refseq;acc:nm_006620]	High confidence		215	322
		LAMP1	Divided	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	Low confidence	1.47982	223	330
	Squared	no value	Subtracted	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	High confidence	143938	407289	263351
		BEST1		bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]	Low confidence	141563	333556	475119
		CDK4	Divided	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]		19.4914	1362.75	69.9153
		RHOBTB2		rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	High confidence	28.2513	48.0356	1357.07
	Rooted	CDK4		cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	Low confidence	2.10117	48.9847	23.3131
			Subtracted			25.6716
		RHOBTB2	Divided	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	High confidence	2.30547	21.225	48.9336
			Subtracted			27.7086
3	Measured	CDK6	Divided	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Low confidence	4.4149	2399.5	543.5
		HLX		homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	High confidence	3.71868	2597.5	698.5
		PSCD2	Subtracted	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]		8126	41482.5	33356.5
		SLC25A43		mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Low confidence	7307	21185	28492
	Ranked	CDK4	Divided	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]		1.47982	223	330
		CDK6	Subtracted	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]		107
		PSCD1	Divided	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	High confidence	1.86667	15	28
		RINT1	Subtracted	rad50-interacting protein 1. [refseq;acc:nm_021930]		105	337	232
	Squared	BEST4		vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]	Low confidence	141539	333506	475045
		CDK6	Divided	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]		19.4914	1362.75	69.9153
		HLX		homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	High confidence	13.8285	1596.92	115.48
		PSCD1	Subtracted	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]		143938	407289	263351
	Rooted	CDK6	Divided	cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534]	Low confidence	2.10117	48.9847	23.3131
			Subtracted			25.6716
		HLX	Divided	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	High confidence	1.92839	50.9657	26.4292
			Subtracted			24.5365
4	Measured	BEST1		bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]	Low confidence	7035.1	36474.3	43509.4
		HBS1L	Divided	hbs1-like. [refseq;acc:nm_006620]	High confidence	3.71868	2597.5	698.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.