MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Value Type	Gene	Interaction Map	green	Network Comparison Type	Filtered	red	network_comparison

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Showing element 1001 to 1050 of 3228 in total

Value Type  : Measured
Interaction Map  : High confidence
Network Comparison Type  : Divided
Filtered  : 1

description	Rank	green	red	network_comparison
eyes absent homolog 2. [swissprot;acc:o00167]	2299	6050.71	5786.15	1.04572
eyes absent homolog 3. [swissprot;acc:q99504]	2274	6044.78	5779.66	1.04587
eyes absent homolog 4. [swissprot;acc:o95677]	2296	6049.99	5784.9	1.04582
ezrin-binding partner pace-1 isoform 1. [refseq;acc:nm_020423]	3228	0.00001	0.00001	1
f-actin capping protein alpha-1 subunit (capz alpha-1). [swissprot;acc:p52907]	1490	6815.41	6340.5	1.0749
f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755]	1497	6812.45	6339.08	1.07467
f-actin capping protein alpha-3 subunit (capz alpha-3) (germ cell- specific protein 3). [swissprot;acc:q96kx2]	1681	6740.66	6304.74	1.06914
f-actin capping protein beta subunit (capz beta). [swissprot;acc:p47756]	1682
f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	100	3225.65	2353.63	1.3705
fad synthetase. [refseq;acc:nm_025207]	1841	3375.34	3591.95	1.06417
far upstream element-binding protein; far upstream element binding protein; fuse-binding protein. [refseq;acc:nm_003902]	2092	6138.8	5817.41	1.05525
farnesyl pyrophosphate synthetase (fpp synthetase) (fps) (farnesyl diphosphate synthetase) [includes: dimethylallyltransferase (ec 2.5.1.1); geranyltranstransferase (ec 2.5.1.10)]. [swissprot;acc:p14324]	1180	4776.19	4392.63	1.08732
fas apoptotic inhibitory molecule. [refseq;acc:nm_018147]	2307	5923.48	5666.91	1.04528
fatty acid desaturase 1; linoleoyl-coa desaturase (delta-6-desaturase)-like 1; delta-5 desaturase; delta-5 fatty acid desaturase. [refseq;acc:nm_013402]	2370	5492.28	5265.95	1.04298
fatty acid desaturase 2; linoleoyl-coa desaturase (delta-6-desaturase)-like 2; delta-6 fatty acid desaturase. [refseq;acc:nm_004265]	2369
fatty acid desaturase 3; linoleoyl-coa desaturase (delta-6-desaturase)-like 3; delta-6 fatty acid desaturase. [refseq;acc:nm_021727]	2367
fatty acid hydroxylase domain containing 1. [refseq;acc:nm_024306]	2204	5326.29	5076.73	1.04916
fatty acid-binding protein, adipocyte (afabp) (adipocyte lipid-binding protein) (albp) (a-fabp). [swissprot;acc:p15090]	1665	6193.02	5791.14	1.0694
fatty acid-binding protein, brain (b-fabp) (brain lipid-binding protein) (blbp) (mammary derived growth inhibitor related). [swissprot;acc:o15540]	1667
fatty acid-binding protein, epidermal (e-fabp) (psoriasis-associated fatty acid-binding protein homolog) (pa-fabp). [swissprot;acc:q01469]	1666
fatty acid-binding protein, heart (h-fabp) (muscle fatty acid-binding protein) (m-fabp) (mammary-derived growth inhibitor) (mdgi). [swissprot;acc:p05413]	1674
fatty aldehyde dehydrogenase (ec 1.2.1.3) (aldehyde dehydrogenase, microsomal) (aldh class 3). [swissprot;acc:p51648]	3181	0.00001	0.00001	1
fatty-acid amide hydrolase (ec 3.1.-.-) (oleamide hydrolase) (anandamide amidohydrolase). [swissprot;acc:o00519]	1951	6245.89	5888.32	1.06073
fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322]	403	4479.76	5201.41	1.16109
ferritin heavy chain (ferritin h subunit). [swissprot;acc:p02794]	620	7012.9	6227.87	1.12605
ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8]	635	7013.53	6228.97	1.12595
ferritin light chain (ferritin l subunit). [swissprot;acc:p02792]	633	7013.19	6228.39	1.126
ferrochelatase, mitochondrial precursor (ec 4.99.1.1) (protoheme ferro-lyase) (heme synthetase). [swissprot;acc:p22830]	3185	0.00001	0.00001	1
fetal brain protein 239 (239fb). [swissprot;acc:q15777]	1053	5198.91	4757.46	1.09279
fibrillarin (34 kda nucleolar scleroderma antigen). [swissprot;acc:p22087]	646	4522.61	4019.88	1.12506
fibrillin 1 precursor. [swissprot;acc:p35555]	2844	0.00001	0.00001	1
fibrillin 2 precursor. [swissprot;acc:p35556]	2955
fibrillin 3. [refseq;acc:nm_032447]	2939
fibulin-1 precursor. [swissprot;acc:p23142]	1304	9248.06	8550.79	1.08154
fibulin-2 precursor. [swissprot;acc:p98095]	1216	9412.9	8670.59	1.08561
ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	21	1865.5	677.5	2.75351
fidgetin-like 1. [refseq;acc:nm_022116]	1491	6510.9	6057.46	1.07486
filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	113	5899.76	4366.44	1.35116
filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	108
fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]	270	19479.8	23640.2	1.21358
fk506-binding protein 1a (ec 5.2.1.8) (peptidyl-prolyl cis-trans isomerase) (ppiase) (rotamase) (12 kda fkbp) (fkbp-12) (immunophilin fkbp12). [swissprot;acc:p20071]	1207	6459.79	5946.33	1.08635
flap endonuclease-1 (ec 3.-.-.-) (maturation factor 1) (mf1). [swissprot;acc:p39748]	2831	0.00001	0.00001	1
flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]	556	7007.7	6167.93	1.13615
flotillin-1. [swissprot;acc:o75955]	1296	6120.64	5655.85	1.08218
folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]	2009	5223.69	4934.48	1.05861
forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	130	2978.53	2234.68	1.33287
forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488]	578	7644.62	6739.81	1.13425
forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	131	2978.57	2234.73	1.33285
forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	132	2980.35	2236.61	1.33253
formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	93	5942.75	4245.52	1.39977

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.