Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Value Type Gene Interaction Map green Network Comparison Type description Filtered network_comparison red
Results: HTML CSV LaTeX Showing element 601 to 650 of 19268 in total
Value Type  : Ranked
Rank
Interaction Map
green
Network Comparison Type
description
Filtered
network_comparison
red
76 High confidence 202.668 Subtracted voltage-dependent calcium channel gamma-3 subunit (neuronal voltage- gated calcium channel gamma-3 subunit). [swissprot;acc:o60359] 1 52.025 254.693
362 Divided db83 protein. [swissprot;acc:p57088] 1.25694 288
2695 spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [swissprot;acc:q13813] 0 1.28905 3474
17069.5 Subtracted enigma protein; lim domain protein. [refseq;acc:nm_005451] 2593.3 14476.2
Low confidence 208.077 diacylglycerol kinase, eta isoform 1. [refseq;acc:nm_152910] 1 18.904 226.981
226.86 Divided nipsnap1 protein. [swissprot;acc:q9bpw8] 1.10017 249.584
12345.3 ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395] 0 1.23945 9960.27
15320 Subtracted dok-like protein. [refseq;acc:nm_024872] 2641.5 12678.5
77 High confidence 202.668 Divided voltage-dependent calcium channel gamma-2 subunit (neuronal voltage- gated calcium channel gamma-2 subunit). [swissprot;acc:q9y698] 1 1.2567 254.692
Subtracted 52.024
11350 nanos (fragment). [sptrembl;acc:q8wy41] 0 2568 8782
11366.5 Divided regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754] 1.28853 8821.32
Low confidence 208.077 Subtracted diacylglycerol kinase, delta (ec 2.7.1.107) (diglyceride kinase) (dgk-delta) (dag kinase delta) (130 kda diacylglycerol kinase) (fragment). [swissprot;acc:q16760] 1 18.904 226.981
215.424 Divided putative adenosylhomocysteinase 3 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:q96hn2] 1.09994 195.851
11915.2 Subtracted dj947l8.1.1 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4v7] 0 2633.3 14548.5
13871.6 Divided adenosine deaminase (ec 3.5.4.4) (adenosine aminohydrolase). [swissprot;acc:p00813] 1.23278 11252.3
78 High confidence 202.668 voltage-dependent calcium channel gamma-8 subunit (neuronal voltage- gated calcium channel gamma-8 subunit). [swissprot;acc:q8wxs5] 1 1.2567 254.693
Subtracted voltage-dependent calcium channel gamma-4 subunit (neuronal voltage- gated calcium channel gamma-4 subunit). [swissprot;acc:q9ubn1] 52.023 254.691
9706.12 Divided repressor of estrogen receptor activity; b-cell associated protein. [refseq;acc:nm_007273] 0 1.27969 7584.72
10406.3 Subtracted e1a binding protein p400; p400 swi2/snf2-related protein; cagh32 protein; trinucleotide repeat containing 12. [refseq;acc:nm_015409] 2552.63 7853.67
Low confidence 215.309 dna fragmentation factor 40 kda subunit (ec 3.-.-.-) (dff-40) (caspase-activated deoxyribonuclease) (caspase-activated dnase) (cad) (caspase-activated nuclease) (cpan). [swissprot;acc:o76075] 1 18.613 233.922
231.635 Divided malignant cell expression-enhanced gene/tumor progression-enhanc. [refseq;acc:nm_024298] 1.0978 211
13236 histone-lysine n-methyltransferase, h3 lysine-79 specific (ec 2.1.1.43) (histone h3-k79 methyltransferase) (h3-k79-hmtase) (dot1-like protein). [swissprot;acc:q8tek3] 0 1.23114 10751
13871.6 Subtracted adenosine deaminase (ec 3.5.4.4) (adenosine aminohydrolase). [swissprot;acc:p00813] 2619.3 11252.3
79 High confidence 202.646 voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02] 1 51.968 254.614
202.668 Divided voltage-dependent calcium channel gamma-3 subunit (neuronal voltage- gated calcium channel gamma-3 subunit). [swissprot;acc:o60359] 1.2567 254.693
11366.5 Subtracted regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754] 0 2545.18 8821.32
12106.5 Divided nuclear rna export factor 5 (tap-like protein 1) (tapl-1). [swissprot;acc:q9h1b4] 1.27901 9465.55
Low confidence 208.803 amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410] 1 1.09742 229.144
228.84 Subtracted dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552] 18.494 247.334
12392 latrophilin 2; lectomedin-1; latrophilin homolog 2 (cow). [refseq;acc:nm_012302] 0 2536 9856
17020.5 Divided melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801] 1.23109 13825.5
80 High confidence 202.668 voltage-dependent calcium channel gamma-4 subunit (neuronal voltage- gated calcium channel gamma-4 subunit). [swissprot;acc:q9ubn1] 1 1.25669 254.691
242.562 Subtracted son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583] 51.491 294.053
11617.9 Divided deltex homolog 1; hdx-1. [refseq;acc:nm_004416] 0 1.27636 9102.34
Subtracted 2515.56
Low confidence 202.005 Divided rad50-interacting protein 1. [refseq;acc:nm_021930] 1 1.09499 221.194
207.874 Subtracted transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186] 18.464 226.338
16094.8 l-lactate dehydrogenase a chain (ec 1.1.1.27) (ldh-a) (ldh muscle subunit) (ldh-m). [swissprot;acc:p00338] 0 2491.5 18586.3
17020.5 Divided melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357] 1.23109 13825.5
81 High confidence 202.016 Subtracted homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839] 1 50.355 252.371
202.646 Divided voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02] 1.25645 254.614
10174.1 Subtracted collagen alpha 5(iv) chain precursor. [swissprot;acc:p29400] 0 2469.4 7704.7
11356 Divided selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611] 1.2736 14463
Low confidence 208.281 transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188] 1 1.09286 227.623
228.693 Subtracted ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2] 18.394 247.087
13236 histone-lysine n-methyltransferase, h3 lysine-79 specific (ec 2.1.1.43) (histone h3-k79 methyltransferase) (h3-k79-hmtase) (dot1-like protein). [swissprot;acc:q8tek3] 0 2485 10751
17020.5 Divided melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364] 1.23109 13825.5
82 High confidence 202.004 Subtracted ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807] 1 50.325 252.329
335.359 Divided guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775] 1.25304 267.636

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/