MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Filtered	Gene	description	Rank	green	red	Network Comparison Type	Value Type	network_comparison	Interaction Map

Results: HTML CSV LaTeX

Showing element 1 to 50 of 38536 in total

Filtered  : 0
Network Comparison Type  : Divided

description	Rank	green	red	Value Type	network_comparison	Interaction Map
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	37	934.348	334.401	Measured	2.79409	High confidence
		1034.13	101.05	Squared	10.2338
	53	18.0183	11.844	Rooted	1.5213
	131	851.77	645.504	Measured	1.31954	Low confidence
	146	1268.51	775.72	Squared	1.63527
	242	13895.8	15260.6	Ranked	1.09822	High confidence
	537	17.0804	16.298	Rooted	1.04801	Low confidence
	629	13590.3	13205.3	Ranked	1.02915
17-beta-hydroxysteroid dehydrogenase type vii-like. [refseq;acc:nm_182829]	627	10050.9	10347.7		1.02953
	768	39.5126	39.0982	Rooted	1.0106
	778	4869.42	4825.89	Measured	1.00902
	815	40451	40270.8	Squared	1.00447
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	19	26.1599	305.45	Measured	11.6763	High confidence
	26	0.344399	44.3683	Squared	128.828
		3.80565	13.7805	Rooted	3.62106
	47	18499.2	12941.7	Ranked	1.42943
	131	9.42485	11.365	Rooted	1.20585	Low confidence
	171	181.734	222.779	Measured	1.22585
	384	14695.2	13533.1	Ranked	1.08587
	697	296.481	307.765	Squared	1.03806
26s proteasome non-atpase regulatory subunit 10 (26s proteasome regulatory subunit p28) (gankyrin). [swissprot;acc:o75832]	316	7355.46	8620.27		1.17196	High confidence
	370	32.0298	30.7424	Rooted	1.04188
	379	10806	11228.4	Ranked	1.03909
	451	2642.79	2683.61	Measured	1.01545
	763	6490.54	6603.33	Squared	1.01738	Low confidence
	771	1609.88	1593.68	Measured	1.01017
	793	23.2445	23.11	Rooted	1.00582
	825	11854.2	11832.8	Ranked	1.00181
26s proteasome non-atpase regulatory subunit 12 (26s proteasome regulatory subunit p55). [swissprot;acc:o00232]	328	5878.56	6747.71	Squared	1.14785	High confidence
	458	28.5146	28.0847	Rooted	1.01531
	474	2263.85	2281.12	Measured	1.00763
	495	11748.1	11725.2	Ranked	1.00195
	591	14694	15800.9	Squared	1.07533	Low confidence
	665	11538	11801.6	Ranked	1.02285
	728	26.5693	26.1642	Rooted	1.01548
	785	2331.31	2349.9	Measured	1.00797
3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8]	299	11512.3	12338.7	Ranked	1.07178	High confidence
	438	44.9836	43.8864	Rooted	1.025
	453	11512.3	12338.7	Ranked	1.07178	Low confidence
	492	5046.33	5038.33	Measured	1.00159	High confidence
	493	17901.1	17901.1	Squared	1
	662	44.9836	43.8864	Rooted	1.025	Low confidence
	822	5046.33	5038.33	Measured	1.00159
	836	17901.1	17901.1	Squared	1
3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]	327	10466.5	9897.29	Ranked	1.05751	High confidence
	376	31.1453	32.3671	Rooted	1.03923
	438	2853.65	2925.57	Measured	1.0252
	442	25.4539	27.2263	Rooted	1.06963	Low confidence
	477	18218.3	18353.1	Squared	1.0074	High confidence
	501	11352.1	10721.7	Ranked	1.0588	Low confidence

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.