MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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description	Gene	Rank	Value Type	Network Comparison Type	Filtered	Interaction Map	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 451 to 500 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

description	Rank	Value Type	Interaction Map	green	red	network_comparison
3-hydroxy-3-methylglutaryl-coenzyme a reductase (ec 1.1.1.34) (hmg-coa reductase). [swissprot;acc:p04035]	3321	Measured	Low confidence	8238.4	8023.42	1.02679
	3423	Rooted		74.7129	72.5008	1.03051
3-hydroxyacyl-coa dehydrogenase type ii (ec 1.1.1.35) (type ii hadh) (endoplasmic reticulum-associated amyloid beta-peptide binding protein) (short-chain type dehydrogenase/reductase xh98g2). [swissprot;acc:q99714]	1886	Squared		43022.5	44788.1	1.04104
	3180	Measured	High confidence	0.00001	0.00001	1
		Ranked
		Squared
		Rooted
	3728	Measured	Low confidence	8094.29	7900.62	1.02451
	3855	Rooted		73.5484	71.5231	1.02832
	4091	Ranked		200.093	202.282	1.01094
3-hydroxyanthranilate 3,4-dioxygenase (ec 1.13.11.6) (3-hao) (3-hydroxyanthranilic acid dioxygenase) (3-hydroxyanthranilate oxygenase). [swissprot;acc:p46952]	111	Squared		74962.3	65044.3	1.15248
	143	Measured		11639.5	10696.6	1.08815
	399	Rooted		88.7007	84.6421	1.04795
	1250	Ranked		176.667	180.665	1.02263
	1764	Rooted	High confidence	69.3348	67.2158	1.03153
	2105	Measured		7295.24	6916.14	1.05481
	2189	Ranked		208.162	209.54	1.00662
	2642	Squared		36579.1	35558.6	1.0287
3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]	646			32866.2	27898	1.17808
	879	Ranked	Low confidence	198.284	203.354	1.02557
	1052	Rooted		74.3827	71.6074	1.03876
	1660	Measured		8232.52	7966.46	1.0334
	1852	Ranked	High confidence	198.154	196.008	1.01095
	1898	Measured		7317.48	6885.11	1.0628
	2412	Rooted		71.371	70.3295	1.01481
	3343	Squared	Low confidence	43619.2	45082.7	1.03355
3-ketoacyl-coa thiolase, peroxisomal precursor (ec 2.3.1.16) (beta- ketothiolase) (acetyl-coa acyltransferase) (peroxisomal 3-oxoacyl- coa thiolase). [swissprot;acc:p09110]	1116		High confidence	31125.2	27235.1	1.14283
	2300	Ranked		192.541	191.563	1.00511
	2305	Measured		7263.87	6946.82	1.04564
	2490	Rooted		72.2607	71.4427	1.01145
	2649	Ranked	Low confidence	192.486	195.904	1.01776
	3780	Measured		8366.35	8168.73	1.02419
	3866	Rooted		75.8932	73.8081	1.02825
	3876	Squared		43332.8	44613.5	1.02955
3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]	515		High confidence	23960.7	19987.6	1.19878
	563	Measured		6222.04	5480.24	1.13536
	767	Rooted		67.7402	63.5181	1.06647
	1025	Ranked		199.266	205.632	1.03195
	2218	Measured	Low confidence	8689.87	8425.53	1.03137
	2252	Ranked		192.92	196.562	1.01888
	2644	Rooted		76.8115	74.3411	1.03323
	4323	Squared		46959.8	48087	1.024
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	949	Ranked		199.196	204.147	1.02485
	971	Rooted	High confidence	65.1892	61.6649	1.05715
	1083	Ranked		213.685	220.118	1.03011
	1140	Rooted	Low confidence	73.8482	71.1233	1.03831
	1274	Measured	High confidence	6371.14	5885	1.08261
	1626	Squared	Low confidence	43316.1	45165.2	1.04269
	2082	Measured		8138.17	7887.47	1.03178
	2609	Squared	High confidence	30015.7	28935	1.03735

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.