Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


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Rank Gene description Network Comparison Type red Interaction Map Value Type green network_comparison Filtered
Results: HTML CSV LaTeX Showing element 1 to 50 of 19268 in total
Value Type  : Measured
Rank
description
Network Comparison Type
red
Interaction Map
green
network_comparison
Filtered
1 ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5] Subtracted 85 High confidence 6410 6325 0
Low confidence
carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976] 40899 32028.5 8870.5 1
lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279] Divided 2399.5 543.5 4.4149
mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] Subtracted 41482.5 High confidence 33356.5 8126
mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3] Divided 364 0.00001 36400000 0
Low confidence
rad50-interacting protein 1. [refseq;acc:nm_021930] 450.5 High confidence 2394.5 5.31521 1
2 28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5] Subtracted 21185 Low confidence 28492 7307
cab2. [refseq;acc:nm_033419] Divided 0.00001 High confidence 174 17400000 0
cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802] 2399.5 Low confidence 543.5 4.4149 1
cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438] Subtracted 41482.5 High confidence 33356.5 8126
homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017] Divided 0.00001 Low confidence 89 8900000 0
lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851] Subtracted 85 High confidence 6410 6325
nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333] 23818.1 Low confidence 19621.3 4196.8
rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6] Divided 450.5 High confidence 2394.5 5.31521 1
3 cell division protein kinase 6 (ec 2.7.1.37) (serine/threonine protein kinase plstire). [swissprot;acc:q00534] 2399.5 Low confidence 543.5 4.4149
cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418] Subtracted 41482.5 High confidence 33356.5 8126
homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774] Divided 2597.5 698.5 3.71868
homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630] 0.00001 Low confidence 89 8900000 0
mitochondrial solute carrier protein. [refseq;acc:nm_145305] Subtracted 21185 28492 7307 1
nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333] 23818.1 High confidence 19621.3 4196.8 0
nucleoporin nup43 (p42). [swissprot;acc:q8nfh3] 5106.93 Low confidence 7500.75 2393.82
pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129] Divided 0.00001 High confidence 109 10900000
4 anchor attachment protein 1; glycophosphatidylinositol anchor attachment 1; anchor attachment protein 1 (gaa1p, yeast) homolog. [refseq;acc:nm_003801] Subtracted 2082 Low confidence 4356 2274
bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090] 36474.3 43509.4 7035.1 1
cytohesin 4. [swissprot;acc:q9uia0] 41482.5 High confidence 33356.5 8126
hbs1-like. [refseq;acc:nm_006620] Divided 2597.5 698.5 3.71868
homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056] 0.00001 Low confidence 89 8900000 0
homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017] High confidence
lysosome-associated membrane glycoprotein 2 precursor (lamp-2) (cd107b antigen). [swissprot;acc:p13473] 2399.5 Low confidence 543.5 4.4149 1
small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578] Subtracted 18704 High confidence 21730 3026 0
5 cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739] 41482.5 33356.5 8126 1
histone h4. [swissprot;acc:p02304] 21773.1 24446.3 2673.2 0
homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630] Divided 0.00001 89 8900000
jumonji protein. [swissprot;acc:q92833] Low confidence 17.5166 1751660
junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2] 1153.5 High confidence 339.5 3.39764 1
lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851] Subtracted 485.286 Low confidence 2740.13 2254.84 0
oxysterol binding protein-related protein 6 (osbp-related protein 6) (orp-6). [swissprot;acc:q9bzf3] Divided 736.5 2113.5 2.86965 1
vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274] Subtracted 36469.3 43503.3 7034
6 homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056] Divided 0.00001 High confidence 89 8900000 0
homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099] 13 Low confidence 0.00001 1300000
junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39] 1153.5 High confidence 339.5 3.39764 1
nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333] Subtracted 36360.3 Low confidence 43368.8 7008.5
oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5] Divided 736.5 2113.5 2.86965
putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172] Subtracted 44490.5 High confidence 36927.5 7563
similar to zinc finger protein 277. [sptrembl;acc:q8wwa6] 7592.37 Low confidence 8836.85 1244.48 0
13174.7 High confidence 15605.1 2430.4
7 28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5] 21185 28492 7307 1
cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] 4660.09 Low confidence 5898.71 1238.62 0

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/