Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Network Comparison Type Value Type Interaction Map red Filtered network_comparison green
Results: HTML CSV LaTeX Showing element 130 to 179 of 3228 in total 
Network Comparison Type	Divided
Value Type	Ranked
Interaction Map	High confidence
Filtered	1

Rank	description	red	network_comparison	green	
130	protein hspc134 (protein cda04). [source:swissprot;acc:q9by43]	94	1.21277	114	
131	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [source:swissprot;acc:p18583]	294.053	1.21228	242.562	
132	tob2 protein (transducer of erbb-2 2). [source:swissprot;acc:q14106]	350	1.2069	290	
133	tob1 protein (transducer of erbb-2 1). [source:swissprot;acc:p50616]	350	1.2069	290	
134	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [source:refseq;acc:nm_032552]	350	1.2069	290	
135	cytoplasmic polyadenylation element binding protein 4. [source:refseq;acc:nm_030627]	350	1.2069	290	
136	cytoplasmic polyadenylation element binding protein 3. [source:refseq;acc:nm_014912]	350	1.2069	290	
137	ras gtpase-activating protein ngap (ras protein activator like 1). [source:swissprot;acc:q9ujf2]	350	1.2069	290	
138	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [source:swissprot;acc:p05323]	194.372	1.20493	234.204	
139	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [source:swissprot;acc:q02410]	271.752	1.20415	225.68	
140	ras-related gtp binding a; ras-related gtp-binding protein. [source:refseq;acc:nm_006570]	59	1.20408	49	
141	ras-related gtp binding c; rag c protein. [source:refseq;acc:nm_022157]	59	1.20408	49	
142	ras-related gtp binding b short isoform; gtp-binding protein ragb. [source:refseq;acc:nm_006064]	59	1.20408	49	
143	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [source:refseq;acc:nm_018685]	59	1.20408	49	
144	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [source:refseq;acc:nm_014592]	265.686	1.20312	319.651	
145	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [source:refseq;acc:nm_147183]	265.639	1.20293	319.546	
146	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [source:refseq;acc:nm_173193]	265.632	1.20291	319.531	
147	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [source:refseq;acc:nm_006333]	50.7983	1.2009	42.3003	
148	sad1/unc-84 protein-like 1. [source:swissprot;acc:o94901]	296.677	1.19841	247.559	
149	atlastin; guanylate-binding protein 3. [source:refseq;acc:nm_015915]	142	1.19718	170	
150	myosin vb (myosin 5b) (fragment). [source:swissprot;acc:q9ulv0]	55	1.19565	46	
151	myosin vc (myosin 5c). [source:swissprot;acc:q9nqx4]	55	1.19565	46	
152	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [source:swissprot;acc:q9y4i1]	55	1.19565	46	
153	chromosome 3p21.1 gene sequence. [source:refseq;acc:nm_013286]	249.663	1.19466	298.263	
154	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [source:swissprot;acc:p49795]	249.663	1.19466	298.263	
155	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [source:swissprot;acc:q96t37]	249.663	1.19466	298.263	
156	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [source:swissprot;acc:o76081]	249.663	1.19466	298.263	
157	transcription factor lbx1. [source:swissprot;acc:p52954]	249.663	1.19466	298.263	
158	mosaic protein lgn. [source:swissprot;acc:p81274]	249.663	1.19466	298.263	
159	regulator of g-protein signaling 17 (rgs17). [source:swissprot;acc:q9ugc6]	249.663	1.19466	298.263	
160	guanine nucleotide-binding protein g(o), alpha subunit 1. [source:swissprot;acc:p09471]	249.663	1.19466	298.263	
161	rap1 gtpase-activating protein 1 (rap1gap). [source:swissprot;acc:p47736]	249.663	1.19466	298.263	
162	nostrin. [source:refseq;acc:nm_052946]	209.299	1.19058	249.187	
163	eap30 subunit of ell complex. [source:refseq;acc:nm_007241]	209.299	1.19058	249.187	
164	liv-1 protein, estrogen regulated. [source:refseq;acc:nm_012319]	209.299	1.19058	249.187	
165	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [source:swissprot;acc:q05329]	209.299	1.19058	249.187	
166	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [source:swissprot;acc:q99747]	209.299	1.19058	249.187	
167	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [source:swissprot;acc:q99259]	209.299	1.19058	249.187	
168	gaba-a receptor-associated protein. [source:sptrembl;acc:q9by60]	82.5916	1.18722	98.0548	
169	apg3p; pc3-96 protein. [source:refseq;acc:nm_022488]	82.5916	1.18722	98.0548	
170	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [source:swissprot;acc:p31483]	227.199	1.17894	192.715	
171	nucleolysin tiar (tia-1 related protein). [source:swissprot;acc:q01085]	227.202	1.17829	192.823	
172	cg9578-like; yeast ypr037w and worm c02c2.6 predicted proteins-like. [source:refseq;acc:nm_152902]	174.667	1.17685	205.556	
173	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [source:swissprot;acc:p13641]	227.032	1.17599	193.056	
174	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [source:swissprot;acc:q96df8]	335	1.17133	286	
175	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [source:refseq;acc:nm_003653]	199.949	1.17123	234.187	
176	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [source:swissprot;acc:q9nr33]	275.754	1.1689	235.908	
177	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [source:sptrembl;acc:q8wwk2]	229.406	1.1663	196.695	
178	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [source:refseq;acc:nm_017892]	226.887	1.1652	194.72	
179	huntingtin-interacting protein hypa/fbp11 (fragment). [source:sptrembl;acc:o75404]	226.884	1.16476	194.79	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/